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Male germ cell-associated kinase

The product of this gene is a serine/threonine protein kinase related to kinases involved in cell cycle regulation. It is expressed almost exclusively in the testis, primarily in germ cells. Studies of the mouse and rat homologs have localized the kinase to the chromosomes during meiosis in spermatogenesis, specifically to the synaptonemal complex that exists while homologous chromosomes are paired. There is, however, a study of the mouse homolog that has identified high levels of expression in developing sensory epithelia so its function may be more generalized. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011] (from NCBI)
Top mentioned proteins: CAN, ACID, HAD, V1a, cytokeratin
Papers using MAK antibodies
Argonaute2 is the catalytic engine of mammalian RNAi
Young John, In PLoS Pathogens, 2003
... α-Vif (ImmunoDiagnostics, Woburn, Massachusetts, United States), rabbit polyclonal antibodies α-HA (Santa Cruz Biotechnology) and α-DDX6 (RCK/p54; Bethyl Laboratories, Montgomery, Texas, United ...
Phosphorylated tau immunoreactivity of granulovacuolar bodies (GVB) of Alzheimer’s disease: localization of two amino terminal tau epitopes in GVB
Zhu Xiongwei et al., In Laboratory investigation; a journal of technical methods and pathology, 1992
... Ser 235/236 (Abcam), mouse monoclonal to total S6 protein (Cell Signaling 54D2), rabbit antibody to p54/RCK (Bethyl Laboratories A300-460), Alz-50 (gift ...
Papers on MAK
Chicken scFvs with an Artificial Cysteine for Site-Directed Conjugation.
Chung et al., Seoul, South Korea. In Plos One, Dec 2015
We prepared four charge-variant H13 artificial cysteine mutants (RCK, DCE, ECD and ECE) as scFv-Ckappa fusion proteins and confirmed that the reactivity of the sulfhydryl group on cysteine is active and their binding activity is retained after the conjugation process.
2014 Conway review lecture, Royal Academy of Medicine in Ireland: "S6, drugs and RCK and Bowl".
Hollywood, Dún Dealgan, Ireland. In Ir J Med Sci, Nov 2015
BACKGROUND: The Conway Review Lecture is held annually by the Royal Academy of Medicine in Ireland Biomedical Sciences Section, to remember the life and scientific work of a world class Irish scientist, Professor Edward J Conway.
A conserved mechanism of TOR-dependent RCK-mediated mRNA degradation regulates autophagy.
Williamson et al., Bethesda, United States. In Nat Cell Biol, Jul 2015
Using yeast and mammalian cells, we report a conserved mechanism of autophagy regulation by RNA helicase RCK family members in association with the decapping enzyme Dcp2.
Investigation and Analysis of Genetic Diversity of Diospyros Germplasms Using SCoT Molecular Markers in Guangxi.
Qin et al., Nanning, China. In Plos One, 2014
silverstris Mak, and D. lotus Linn were collected from different eco-climatic zones in Guangxi and were analyzed using SCoT markers.
Copy number variations in spermatogenic failure patients with chromosomal abnormalities and unexplained azoospermia.
Liu et al., Changchun, China. In Genet Mol Res, 2014
The involved genes include EDDM3A, EDDM3B, HLA-DRB1, HLA-DQA1, POTE B, GOLGA8C, DNMT3L, ALF, NPHP1, NRG1, RID2, ADAMTS20, TWF1, COX10, MAK, and DNEL1.
Efficient In Silico Identification of a Common Insertion in the MAK Gene which Causes Retinitis Pigmentosa.
Comander et al., Boston, United States. In Plos One, 2014
One such mutation is a recently-identified Alu insertion into the Male Germ Cell-Associated Kinase (MAK) gene, which is missed by standard NGS-based variant callers.
DDX6 and its orthologs as modulators of cellular and viral RNA expression.
Ostareck-Lederer et al., Aachen, Germany. In Wiley Interdiscip Rev Rna, 2014
DDX6 (Rck/p54), a member of the DEAD-box family of helicases, is highly conserved from unicellular eukaryotes to vertebrates.
Pharmacological consequences of the coexpression of BK channel α and auxiliary β subunits.
Latorre et al., Bogotá, Colombia. In Front Physiol, 2013
BK channels are tetramers characterized by a pore-forming α subunit containing seven transmembrane segments (instead of the six found in voltage-dependent K(+) channels) and a large C terminus composed of two regulators of K(+) conductance domains (RCK domains), where the Ca(2+)-binding sites reside.
A BK (Slo1) channel journey from molecule to physiology.
Latorre et al., Valparaíso, Chile. In Channels (austin), 2013
Regions for voltage as well as Ca (2+) sensitivity have been identified, and the crystal structure generated by the 2 RCK domains contained in the C-terminal of the channel has been described.
Gating of the TrkH ion channel by its associated RCK protein TrkA.
Zhou et al., New York City, United States. In Nature, 2013
TrkH assembles with TrkA, a cytosolic protein comprising two RCK (regulate the conductance of K(+)) domains, which are found in certain K(+) channels and control their gating.
Multiple binding of repressed mRNAs by the P-body protein Rck/p54.
Weil et al., Paris, France. In Rna, 2012
Rck/p54 recruitment by sequence-specific translational repressors leads to further binding of Rck/p54 along mRNA molecules, resulting in their masking, unwinding, and ultimately recruitment to P-bodies.
HIV-1 Gag co-opts a cellular complex containing DDX6, a helicase that facilitates capsid assembly.
Lingappa et al., Seattle, United States. In J Cell Biol, 2012
assembling HIV-1 co-opts a preexisting host complex containing cellular facilitators such as DDX6, which the virus uses to catalyze capsid assembly
Nesfatin-1 action in the brain increases insulin sensitivity through Akt/AMPK/TORC2 pathway in diet-induced insulin resistance.
Yang et al., Chongqing, China. In Diabetes, 2012
our findings indicate that the ICV nesfatin-1 resulted in increased insulin signaling through Akt/AMPK/ TORC2 and provide a potential mechanism for increased insulin sensitivity.
Nucleobindin-2 is a positive modulator of EGF-dependent signals leading to enhancement of cell growth and suppression of adipocyte differentiation.
Mori et al., Maebashi, Japan. In Endocrinology, 2012
nucleobindin-2 regulates EGF-stimulated MAPK kinase/Erk signaling, cell proliferation, and adipocyte differentiation
mTOR-dependent modulation of gastric nesfatin-1/NUCB2.
Zhang et al., Beijing, China. In Cell Physiol Biochem, 2011
Gastric mTOR is a gastric energy sensor whose activity is linked to the regulation of gastric nesfatin-1/NUCB2.
Roquin binds inducible costimulator mRNA and effectors of mRNA decay to induce microRNA-independent post-transcriptional repression.
Heissmeyer et al., München, Germany. In Nat Immunol, 2010
The repression was dependent on the RNA helicase Rck, and roquin interacted with Rck and the enhancer of decapping Edc4, which act together in mRNA decapping.
Structure of the gating ring from the human large-conductance Ca(2+)-gated K(+) channel.
Jiang et al., Dallas, United States. In Nature, 2010
The structure reveals four intracellular subunits, each comprising two tandem RCK domains, assembled into a gating ring similar to that seen in the MthK channel and probably representing its physiological assembly.
Structure of the human BK channel Ca2+-activation apparatus at 3.0 A resolution.
MacKinnon et al., New York City, United States. In Science, 2010
Two tandem C-terminal regulator of K+ conductance (RCK) domains from each of four channel subunits form a 350-kilodalton gating ring at the intracellular membrane surface.
Translational control by cytoplasmic polyadenylation in Xenopus oocytes.
de Moor et al., Nottingham, United Kingdom. In Biochim Biophys Acta, 2008
2. The signal transduction that leads to the activation of CPE-mediated polyadenylation during oocyte maturation, including the potential roles of kinases such as MAPK, Aurora A, CamKII, cdk1/Ringo and cdk1/cyclin B. 3. The role of deadenylation and translational repression, including the potential involvement of PARN, CCR4/NOT, maskin, pumilio, Xp54 (Ddx6, Rck), other P-body components and isoforms of the cap binding initiation factor eIF4E.
Mammalian stress granules and processing bodies.
Anderson et al., Boston, United States. In Methods Enzymol, 2006
Both SGs and PBs contain mRNA, eIF4E, microRNAs and argonaute proteins, and various regulators of mRNA stability and translation (TTP, RCK/p54, and CPEB).
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