Borderline personality disorder and childhood maltreatment: a genome-wide methylation analysis.
Genève, Switzerland. In Genes Brain Behav, Feb 2015
Several CpGs within or near the following genes (IL17RA, miR124-3, KCNQ2, EFNB1, OCA2, MFAP2, RPH3AL, WDR60, CST9L, EP400, A2ML1, NT5DC2, FAM163A and SPSB2) were found to be differently methylated, either in BPD compared with MDD or in relation to the severity of childhood maltreatment.
MAGP1, the extracellular matrix, and metabolism.
Saint Louis, United States. In Adipocyte, 2015
We recently published a series of studies that identified a novel mechanism whereby an extracellular matrix molecule, MAGP1 (microfibril associated glycoprotein 1), can regulate energy metabolism in adipose tissue.
Oophorectomy-induced bone loss is attenuated in MAGP1-deficient mice.
Saint Louis, United States. In J Cell Biochem, 2012
These studies provide support for increased RANKL expression associated with MAGP1 deficiency and provide a link to altered TGF-beta signaling as a possible causative signaling pathway regulating RANKL expression in MAGP1-deficient osteoblasts.
Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function.
Leicester, United Kingdom. In Nat Genet, 2011
We identified new regions showing association (combined P < 5 × 10(-8)) with pulmonary function in or near MFAP2, TGFB2, HDAC4, RARB, MECOM (also known as EVI1), SPATA9, ARMC2, NCR3, ZKSCAN3, CDC123, C10orf11, LRP1, CCDC38, MMP15, CFDP1 and KCNE2.
[Regulation of elastin synthesis].
Paris, France. In J Soc Biol, 2000
Elastin is the main protein of elastic fibers and confers the property of elastic recoil to the tissues such as arteries, lung, elastic cartilage,... Elastin synthesis goes through several steps: gene transcription, alternative splicing of pre-mRNA, mRNA translation, hydroxylation of some proline residues of the newly synthesized protein-tropoelastin-, association of with a 67 kDa chaperone protein, secretion of tropoelastin molecules in the extracellular space, and their deposition on the microfibrillar scaffold which contains fibrillin 1, fibrillin 2, MAGP 1 and MAGP 2,....