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Melanoma antigen family B, 2

MAGE-B2, CT3.2, DAM-6, MAGE Xp-2
This gene is a member of the MAGEB gene family. The members of this family have their entire coding sequences located in the last exon, and the encoded proteins show 50 to 68% sequence identity to each other. The promoters and first exons of the MAGEB genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. This gene is localized in the DSS (dosage-sensitive sex reversal) critical region. It is expressed in testis and placenta, and in a significant fraction of tumors of various histological types. The MAGEB genes are clustered on chromosome Xp22-p21. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: MAGE-B1, HAD, CAN, OUT, NY-ESO-1
Papers on MAGE-B2
Aberrant demethylation and expression of MAGEB2 in a subset of malignant peripheral nerve sheath tumors from neurofibromatosis type 1.
New
Nakagawa et al., Tokyo, Japan. In J Dermatol Sci, Dec 2015
Although cancer-testis antigens, including MAGEB2, are potential therapeutic targets for cancer in medical practice, information on MAGEB2 in MPNST is scarce.
Preferential expression of cancer/testis genes in cancer stem-like cells: proposal of a novel sub-category, cancer/testis/stem gene.
Sato et al., Sapporo, Japan. In Tissue Antigens, 2013
Eighteen genes (MAGEA2, MAGEA3, MAGEA4, MAGEA6, MAGEA12, MAGEB2, GAGE1, GAGE8, SPANXA1, SPANXB1, SPANXC, XAGE2, SPA17, BORIS, PLU-1, SGY-1, TEX15 and CT45A1) showed higher expression levels in SP cells than in MP cells, whereas 10 genes (BAGE1, BAGE2, BAGE4, BAGE5, XAGE1, LIP1, D40, HCA661, TDRD1 and TPTE) showed similar expression levels in SP cells and MP cells.
Histone modifications and expression of DAM6 gene in peach are modulated during bud dormancy release in a cultivar-dependent manner.
Ríos et al., Moncada, Spain. In New Phytol, 2012
Histone modifications in DAM6 gene were investigated by chromatin immunoprecipitation in two different cultivars.
MAGEB2 is activated by promoter demethylation in head and neck squamous cell carcinoma.
Califano et al., Baltimore, United States. In Plos One, 2011
We identified MAGEB2 as having significant promoter demethylation in primary head and neck squamous cell carcinoma tissues.
Cancer testis antigens in newly diagnosed and relapse multiple myeloma: prognostic markers and potential targets for immunotherapy.
Sonneveld et al., Rotterdam, Netherlands. In Haematologica, 2011
MAGEC1, MAGEB2 and SSX1 were the most frequent testis-restricted cancer testis antigens in both data sets.
Expression patterns of cancer-testis antigens in human embryonic stem cells and their cell derivatives indicate lineage tracks.
Gordeeva et al., Moscow, Russia. In Stem Cells Int, 2010
Despite similarity of the hES and hEC cell expression patterns, MAGE-A2 and MAGE-B2 were detected only in hEC cells but not in hES cells.
The DNA demethylating agent 5-aza-2'-deoxycytidine induces expression of NY-ESO-1 and other cancer/testis antigens in myeloid leukemia cells.
Lübbert et al., Freiburg, Germany. In Leuk Res, 2010
Since the expression of CTA genes is usually very low or absent in myeloid leukemias, we treated various AML cell lines with 5-aza-2'-deoxycytidine (DAC) and quantified mRNA expression of the CTAs NY-ESO-1, MAGEA1, MAGEA3 and MAGEB2.
Gene expression of DAM5 and DAM6 is suppressed by chilling temperatures and inversely correlated with bud break rate.
Bielenberg et al., United States. In Plant Mol Biol, 2010
Of these genes, DAM3, DAM5 and DAM6 were winter expressed, suggesting a role for these genes during endodormancy.
MAGE-B2 autoantibody: a new biomarker for pediatric systemic lupus erythematosus.
McCurdy et al., Los Angeles, United States. In J Rheumatol, 2008
OBJECTIVE: Melanoma-associated antigen gene B2 (MAGE-B2) encodes an embryonic antigen normally silenced after birth except in testis and placenta.
Valproate induces widespread epigenetic reprogramming which involves demethylation of specific genes.
GeneRIF
Szyf et al., Montréal, Canada. In Carcinogenesis, 2007
Valproic acid causes a change in acetylation of this gene.
mRNA expression of MAGE-A3 gene in leukemia cells.
Miranda et al., Mexico. In Leuk Res, 2007
AML were positive for one of the three genes analyzed (MAGE-A1 1/32; MAGE-A3 10/32; MAGE-B2 3/12).
Identification of tumor associated antigens recognized by IgG from tumor-infiltrating B cells of lung cancer: correlation between Ab titer of the patient's sera and the clinical course.
Yasumoto et al., Kitakyūshū, Japan. In Cancer Sci, 2005
The sero-reactive clones were sequenced and one of these antigens was revealed to be MAGE-B2 whereas the others were novel antigens.
MAGED4-expression in renal cell carcinoma and identification of an HLA-A*25-restricted MHC class I ligand from solid tumor tissue.
Stevanovic et al., Tübingen, Germany. In Cancer Biol Ther, 2005
Among the other MAGE family members only MAGEB2 and -C1 and the broadly expressed MAGED1, -D2, -F1 and -H1 were expressed in RCC.
Expression of cancer/testis (CT) antigens in Chinese hepatocellular carcinoma and its correlation with clinical parameters.
Chen et al., Beijing, China. In Cancer Lett, 2005
NY-ESO-1, 42.5%; MAGE-B1, 52.0%; MAGE-B2, 60.0%; MAGE-C1, 48.0%; MAGE-C2, 68.0%; and SCP-1, 33.3%.
Hypertonicity induction of melanoma antigen, a tumor-associated antigen.
GeneRIF
Lee et al., Ch'angwŏn, South Korea. In Mol Cells, 2002
Results show that hypertonic culture medium differentially induces the expression of melanoma antigens B1 and B2 (MAGE-B1, -B2) in different human tumor cell lines.
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