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Melanoma antigen family B, 1

This gene is a member of the MAGEB gene family. The members of this family have their entire coding sequences located in the last exon, and the encoded proteins show 50 to 68% sequence identity to each other. The promoters and first exons of the MAGEB genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. This gene is localized in the DSS (dosage-sensitive sex reversal) critical region, and expressed in testis and in a significant fraction of tumors of various histological types. This gene and other MAGEB members are clustered on chromosome Xp22-p21. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene, however, the full length nature of some variants has not been defined. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: POLYMERASE, MAGE-B2, OUT, CAN, Mage-b3
Papers on MAGE-B1
Differential expression profile of MAGE family in non-small-cell lung cancer.
Lin et al., Kao-hsiung, Taiwan. In Lung Cancer, 2007
Nearly 32 MAGE genes have been differential expressed in NSCLC except MAGE-B1 and -E2.
Prevention of metastases with a Mage-b DNA vaccine in a mouse breast tumor model: potential for breast cancer therapy.
Gravekamp et al., San Antonio, United States. In Breast Cancer Res Treat, 2005
Here we report on the development and effectiveness of a TAA-based DNA vaccine encoding Mage-b1/2, the mouse homologue of the human MAGE-B1/2.
Expression of cancer/testis (CT) antigens in Chinese hepatocellular carcinoma and its correlation with clinical parameters.
Chen et al., Beijing, China. In Cancer Lett, 2005
NY-ESO-1, 42.5%; MAGE-B1, 52.0%; MAGE-B2, 60.0%; MAGE-C1, 48.0%; MAGE-C2, 68.0%; and SCP-1, 33.3%.
[Cloning and subcellular localization of apr-1--a new gene of tumor specific antigen family].
Wang et al., Xi'an, China. In Ai Zheng, 2005
Apr-1 shared homology with MAGE-A1, MAGE-B1, MAGE-C1, MAGE-D1, and Necdin.
Prognostic significance of cancer-testis gene expression in resected non-small cell lung cancer patients.
Traversari et al., Italy. In Oncol Rep, 2004
On the contrary, BAGE and MAGE-B1 were expressed less frequently (17% and 11%, respectively).
[Expression of MAGE-B genes in hepatocellular carcinoma].
Zhu et al., Beijing, China. In Zhonghua Zhong Liu Za Zhi, 2004
METHODS: The expression of MAGE-B1, B2, A1 and A3 mRNA was detected using RT-PCR in HCC tissues and the corresponding adjacent non-HCC tissues from 47 HCC patients, 30 samples of cirrhosis and normal liver tissues.
Potential mouse tumor model for pre-clinical testing of mage-specific breast cancer vaccines.
Gravekamp et al., San Antonio, United States. In Breast Cancer Res Treat, 2002
Here, in situ developed mammary tumors of MMTV-v-Ha-ras and MMTV-c-myc transgenic mice and normal mammary, liver, spleen, and testis were screened for expression of tumor-associated antigens (TAA) Mage-b1/2/3 by reverse-transcriptase polymerase chain reaction (RT-PCR) and Southern blot hybridization.
Hypertonicity induction of melanoma antigen, a tumor-associated antigen.
Lee et al., Ch'angwŏn, South Korea. In Mol Cells, 2002
Results show that hypertonic culture medium differentially induces the expression of melanoma antigens B1 and B2 (MAGE-B1, -B2) in different human tumor cell lines.
Expression patterns of cancer testis antigens in testicular germ cell tumors and adjacent testicular tissue.
Okada et al., Ōtsu, Japan. In J Urol, 2001
Specifically all 13 seminomas (100%) demonstrated the positive expression of MAGE-B1 and MAGE-B2, while 3 of 17 nonseminomatous germ cell tumor samples (18%) showed positive expression of these genes.
Expression of MAGE-B genes in esophageal squamous cell carcinoma.
Sugimachi et al., Beppu, Japan. In Jpn J Cancer Res, 2001
The MAGE-B (MAGE-B1, -B2, -B3, and -B4) genes share strong homology with the MAGE-A gene family.
Cloning of the first invertebrate MAGE paralogue: an epitope that activates T-cells in humans is highly conserved in evolution.
Berensonb et al., Los Angeles, United States. In Dev Comp Immunol, 2000
A conceptual translation of the cDNA of DMAGE identifies a putative protein that contains a motif that shares eight out of nine amino acids with the previously identified promiscuous, HLA-A2 restricted antigenic epitope in the C-terminus of human MAGE-B1 and -B2.
Two members of the human MAGEB gene family located in Xp21.3 are expressed in tumors of various histological origins.
Boon et al., Brussels, Belgium. In Genomics, 1998
It contains four MAGE-related genes, which we propose to name MAGE-B1, B2, B3, and B4 (HGMW-approved symbols MAGEB1, MAGEB2, MAGEB3, and MAGEB4).
Sex determining gene on the X chromosome short arm: dosage sensitive sex reversal.
Matsuo et al., Tokyo, Japan. In Acta Paediatr Jpn, 1996
Molecular approaches have localized DSS to a 160 kb region and isolated candidate genes such as DAX-1 and MAGE-Xp, but there has been no formal evidence equating the candidate gene with DSS.
Structure, chromosomal location, and expression pattern of three mouse genes homologous to the human MAGE genes.
Boon et al., Belgium. In Genomics, 1995
Since this region is syntenic to the human Xp21.1-p22.1 region, we conclude that Smage1 and Smage2 are homologous to the MAGE-Xp rather than to the MAGE-Xq genes.
Isolation and characterization of a MAGE gene family in the Xp21.3 region.
Monaco et al., Oxford, United Kingdom. In Proc Natl Acad Sci U S A, 1995
We have mapped and sequenced cDNA and genomic clones corresponding to this gene, MAGE-Xp, and shown that the last exon contains the open reading frame and is present in a minimum of five copies in a 30-kb interval.
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