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Melanoma antigen family A, 8

This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Oct 2009] (from NCBI)
Top mentioned proteins: MAGE-3, MAGE-1, POLYMERASE, HLA-A, MAGE-2
Papers on MAGE-8
Prediction of HLA-A2-restricted CTL epitope specific to HCC by SYFPEITHI combined with polynomial method.
Sui et al., Xi'an, China. In World J Gastroenterol, 2005
METHODS: MAGE-1, MAGE-3, MAGE-8, P53 and AFP were selected as objective antigens in this study for the close association with HCC.
Expression of the MAGE gene family in human hepatocellular carcinoma.
Makuuchi et al., Beppu, Japan. In Cancer, 1999
RESULTS: The expression rate of each MAGE gene was as follows: MAGE-1 and -3 were expressed in approximately 68% of the tumors; MAGE-8 was expressed in 46%; and MAGE-2, -6, -10, -11, and -12 were expressed in approximately 30%.
Expression spectrum of melanoma antigen-encoding gene family members in colorectal carcinoma.
Akiyoshi et al., Beppu, Japan. In Arch Pathol Lab Med, 1998
On the other hand, expression was recognized in tumor samples, ranging from 5% of samples for MAGE-6 to 44% for MAGE-8.
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