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Melanoma antigen family A, 1

This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: MAGE-3, POLYMERASE, CAN, tyrosinase, MAGE-2
Papers on MAGE-1
Circulating tumor and cancer stem cells in hepatitis C virus-associated liver disease.
El-Labbody et al., Cairo, Egypt. In World J Gastroenterol, 2015
The expression levels of the CSCs markers (CD133 and CD90) as well as telomerase, melanoma antigen encoding gene 1 (MAGE1) and MAGE3 were assessed by RT-PCR and quantitative real-time polymerase chain reactions.
Phase I trial of a multi-epitope-pulsed dendritic cell vaccine for patients with newly diagnosed glioblastoma.
Yu et al., Los Angeles, United States. In Cancer Immunol Immunother, 2013
METHODS: TAA epitopes included HER2, TRP-2, gp100, MAGE-1, IL13Rα2, and AIM-2.
Phase I/II study of immunotherapy using tumor antigen-pulsed dendritic cells in patients with hepatocellular carcinoma.
Onji et al., Japan. In Int J Oncol, 2012
The DC vaccine was prepared by pulsing DCs with cytoplasmic transduction peptide-attached α-fetoprotein, glypican-3 and MAGE-1 recombinant fusion proteins and cultivating them in the presence of maturation cocktail.
Cancer-testis and melanocyte-differentiation antigen expression in malignant glioma and meningioma.
Bruce et al., New York City, United States. In J Clin Neurosci, 2012
The following primers were analyzed for CTA: LAGE-1, NY-ESO-1, MAGE-1, MAGE-3, MAGE-4, MAGE-10, CT-7, CT-10, HOM-MEL 40, BAGE, and SCP-1; and for MDA: tyrosinase, gp100, MELAN-A/MART-1, and TRP-2.
Cancer/testis antigens and urological malignancies.
Getzenberg et al., Baltimore, United States. In Nat Rev Urol, 2012
There has been an explosion in CTA-based research since CTAs were first identified in 1991 and MAGE-1 was shown to elicit an autologous cytotoxic T-lymphocyte (CTL) response in a patient with melanoma.
Evaluation of MAGE A1 in oral squamous cell carcinoma.
Gomez et al., Belo Horizonte, Brazil. In Oncol Rep, 2012
results show the absence and/or low expression of MAGE A1 transcripts in oral squamous cell carcinoma; presence of hypomethylation at a small level at the promoter site of MAGE A1 was detected in both oral squamous cell carcinoma and normal oral mucosa
MAGE A1-A6 RT-PCR and MAGE A3 and p16 methylation analysis in induced sputum from patients with lung cancer and non-malignant lung diseases.
Jeon et al., Taegu, South Korea. In Oncol Rep, 2012
Report MAGEA1-A6 expression in sputum suggests presence of lung cancer cells or precancerous cells.
[Glycosyl-phosphatidylinositol-anchored interleukin-2 expressed on tumor-derived exosomes induces anti-tumor immune response].
Luo et al., Chongqing, China. In Zhonghua Zhong Liu Za Zhi, 2011
Ex/GPI-IL-2 were small vesicular and saucer-shaped in diameter of 30-90 nm, containing heat shock protein 70, intercellular adhesion molecule-1, MAGE-1 and GPI-IL-2.
Clinical significance of melanoma antigen-encoding gene-1 (MAGE-1) expression and its correlation with poor prognosis in differentiated advanced gastric cancer.
Kuwano et al., Maebashi, Japan. In Ann Surg Oncol, 2011
High MAGE-1 is associated with differentiated advanced gastric cancer.
MAGE expressions mediated by demethylation of MAGE promoters induce progression of non-small cell lung cancer.
Motoyama et al., Yamagata, Japan. In Anticancer Res, 2011
MAGE1 expression mediated by demethylation of MAGE1 promoter induce progression of non-small cell lung cancer.
Frequent expression of MAGE1 tumor antigens in bronchial epithelium of smokers without lung cancer.
Mao et al., In Exp Ther Med, 2011
Melanoma antigens (MAGE) are frequently expressed in lung cancer and are promising targets of anticancer immunotherapy.
Coexpression of MAGE-A peptides and HLA class I molecules in hepatocellular carcinoma.
Izbicki et al., Hamburg, Germany. In Anticancer Res, 2010
MAGE-A peptides and HLA class I molecules are expressed in hepatocellular carcinoma
Tumoral and immunologic response after vaccination of melanoma patients with an ALVAC virus encoding MAGE antigens recognized by T cells.
Boon et al., Brussels, Belgium. In J Clin Oncol, 2006
PURPOSE: To evaluate the toxicity, antitumoral effectiveness, and immunogenicity of repeated vaccinations with ALVAC miniMAGE-1/3, a recombinant canarypox virus containing a minigene encoding antigenic peptides MAGE-3(168-176) and MAGE-1(161-169), which are presented by HLA-A1 and B35 on tumor cells and can be recognized by cytolytic T lymphocytes (CTLs).
Evaluation of a 7-day continuous intravenous infusion of decitabine: inhibition of promoter-specific and global genomic DNA methylation.
Karpf et al., Salt Lake City, United States. In J Clin Oncol, 2005
Quantitative polymerase chain reaction demonstrated significant MAGE-1 promoter hypomethylation by 14 days after the start of treatment in all 13 treatment cycles examined.
[Antitumor vaccines: conception, development and evaluation in humans].
Moingeon, France. In Ann Pharm Fr, 2002
A series of phase I/II clinical studies evaluating ALVAC recombinants carrying either the CEA, p53, MAGE1 or MAGE3 genes, administered through the subcutaneous, intradermal or intravenous routes, has shown that this approach is safe and can induce tumor-specific antibody or T cell responses in at least some of the patients.
The immunology and immunotherapy of breast cancer: an update.
Hadden, Tampa, United States. In Int J Immunopharmacol, 1999
CMI and humoral immune reactivity have been demonstrated to autologous tumor and a variety of tumor-associated antigens (TAA) have been implicated including CEA, HER-2/neu, MAGE-1, p53, T/Tn and MUC-1.
[Tumor antigens recognized by T-lymphocytes in human cancers. New advances and therapeutic perspectives].
Olive et al., Marseille, France. In Pathol Biol (paris), 1998
The melanoma antigen coded by the MAGE-1 gene was the first tumor antigen described in human cancer.
Breast cancer-associated antigen, DF3/MUC1, induces apoptosis of activated human T cells.
Nadler et al., Boston, United States. In Nat Med, 1996
Given the plethora of well-documented breast carcinoma-associated antigens in humans including MAGE-1, -2 and -3, mutated p53, p21ras, HER-2/neu and DF3/MUC-1, coupled with evidence that humoral and cytotoxic T-cell responses against these antigens exist, the central dilemma facing tumor immunologists is why the host immune response is so inefficient.
Development of cancer vaccine by tumor rejection antigens.
Shichijo et al., Kurume, Japan. In Int Rev Immunol, 1996
MAGE-1 proteins are normal tissue antigens compartmentalized in the particular testicular cells playing an important role in the early phase of the spermatogenesis.
BAGE: a new gene encoding an antigen recognized on human melanomas by cytolytic T lymphocytes.
van der Bruggen et al., Brussels, Belgium. In Immunity, 1995
Some of them are encoded by genes MAGE-1 and MAGE-3, which are not expressed in normal tissues except in testis.
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