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Myelin associated glycoprotein

MAG, Myelin-Associated Glycoprotein
The protein encoded by this gene is a type I membrane protein and member of the immunoglobulin superfamily. It is thought to be involved in the process of myelination. It is a lectin that binds to sialylated glycoconjugates and mediates certain myelin-neuron cell-cell interactions. Three alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq, Nov 2010] (from NCBI)
Top mentioned proteins: CD45, CAN, ACID, Nogo, MBP
Papers using MAG antibodies
BDNF attenuates functional and structural disorders in nerves of galactose-fed rats.
Singh Shree Ram, In PLoS ONE, 1996
... #sc-25669, 1∶25), goat anti-MAG (Santa Cruz Biotechnology, cat ...
Papers on MAG
Designed synthesis of carbon-functional magnetic graphene mesoporous silica materials using polydopamine as carbon precursor for the selective enrichment of N-linked glycan.
Deng et al., Shanghai, China. In Talanta, Mar 2016
In this work, carbon-functionalized magnetic graphene /mesoporous silica materials (C-Mag G@mSiO2 materials) with high content of carbon were designed and synthesized by using polydopamine as carbon precursor.
Ketamine and MAG Lipase Inhibitor-Dependent Reversal of Evolving Depressive Behavior during Forced Abstinence from Alcohol Drinking.
Winder et al., Nashville, United States. In Neuropsychopharmacology, Feb 2016
Pretreatment with the monoacylglycerol (MAG) lipase inhibitor JZL-184 also reduced affective disturbances in the NSFT in ethanol withdrawn mice, and this effect was prevented by co-administration of the CB1 inverse agonist rimonabant.
A Novel Pathway for Triacylglycerol Biosynthesis is Responsible for the Accumulation of Massive Quantities of Glycerolipids in the Surface Wax of Bayberry (Myrica pensylvanica) Fruit.
Ohlrogge et al., East Lansing, United States. In Plant Cell, Feb 2016
Radiolabeling identified sn-2 MAG as the first glycerolipid intermediate.
Protein phosphatase 2A (PP2A) activation promotes axonal growth and recovery in the CNS.
Huang et al., Wuhan, China. In J Neurol Sci, Jan 2016
In our study, we found that the major CNS inhibiting substrates, including chondroitin sulfate proteoglycans (CSPGs) and myelin associated glycoproteins (MAG), activated epidermal growth factor receptor (EGFR), but inactivated PP2A and downstream CRMP2.
The Neural Stem Cell Microenvironment: Focusing on Axon Guidance Molecules and Myelin-Associated Factors.
Jin et al., Wenzhou, China. In J Mol Neurosci, Aug 2015
Recent reports have implicated three myelin-derived inhibitors, NogoA, myelin-associated glycoprotein (MAG), and oligodendrocyte-myelin glycoprotein (OMgp), as well as several axon guidance molecules as regulators of NSC survival, proliferation, migration, and differentiation.
Looking downstream: the role of cyclic AMP-regulated genes in axonal regeneration.
Hannila et al., New York City, United States. In Front Mol Neurosci, 2014
Elevation of intracellular cyclic AMP (cAMP) levels has proven to be one of the most effective means of overcoming inhibition of axonal regeneration by myelin-associated inhibitors such as myelin-associated glycoprotein (MAG), Nogo, and oligodendrocyte myelin glycoprotein.
Insights into the physiological role of CNS regeneration inhibitors.
Giger et al., Ann Arbor, United States. In Front Mol Neurosci, 2014
Prototypic CNS regeneration inhibitors are broadly expressed in the healthy and injured brain and spinal cord and include myelin-associated glycoprotein (MAG), the reticulon family member NogoA, oligodendrocyte myelin glycoprotein (OMgp), and chondroitin sulfate proteoglycans (CSPGs).
Immunotherapy strategies for spinal cord injury.
Qiu et al., Chongqing, China. In Curr Pharm Biotechnol, 2014
In addition, myelinassociated inhibitors (MAIs) in the injured spinal cord, such as Nogo, myelin-associated glycoprotein (MAG) and oligodendrocyte- myelin glycoprotein (OMgp) are known to prevent axonal regeneration through their co-receptors, and to trigger demyelinating autoimmunity through T cell-mediated harmful autoimmune response.
MAG, myelin and overcoming growth inhibition in the CNS.
Rosen et al., Cambridge, United States. In Front Mol Neurosci, 2014
Myelin-associated glycoprotein (MAG) was the first myelin-derived growth inhibitory protein identified, and its inhibitory activity was initially elucidated in 1994 independently by the Filbin lab and the McKerracher lab using cell-based and biochemical techniques, respectively.
The influence of glutamatergic receptor antagonists on biochemical and ultrastructural changes in myelin membranes of rats subjected to experimental autoimmune encephalomyelitis.
Sulkowski et al., Warsaw, Poland. In Folia Neuropathol, 2014
The aim of the study was to test the effects of the glutamatergic receptor antagonists amantadine and memantine (antagonists of NMDA receptors), LY 367384 (an antagonist of mGluR1), and MPEP (an mGluR5 antagonist) on the development of neurological symptoms in immunized animals, morphological changes in cerebral myelin, and expression of mRNA of the principal myelin proteins PLP, MBP, MOG, MAG, and CNPase.
CRMP4 mediates MAG-induced inhibition of axonal outgrowth and protection against Vincristine-induced axonal degeneration.
Ohshima et al., Tokyo, Japan. In Neurosci Lett, 2012
MAG-mediated axon protection against VNC is suppressed in CRMP4-/- DRG neurons.
Loss of myelin-associated glycoprotein in kearns-sayre syndrome.
Mahad et al., Newcastle upon Tyne, United Kingdom. In Arch Neurol, 2012
Primary mitochondrial respiratory chain defects affecting the white matter, and unrelated to inflammation, are associated with MAG loss and central nervous system demyelination.
Age-related changes in myelin morphology, electrophysiological property and myelin-associated protein expression of mouse sciatic nerves.
Ding et al., Nantong, China. In Neurosci Lett, 2011
myelin-associated glycoprotein (MAG) performs distinct actions on the formation, maturation, degeneration and regeneration of sciatic nerve myelin sheath.
Non-anti-MAG DADS neuropathy as a variant of CIDP: clinical, electrophysiological, laboratory features and response to treatment in 10 cases.
Léger et al., Paris, France. In Eur J Neurol, 2011
Distal acquired demyelinating symmetric neuropathy without anti-MAG antibodies is more likely to be considered a variant of chronic inflammatory demyelinating polyradiculoneuropathy, including a hematological or immunological condition.
Myelin-associated glycoprotein protects neurons from excitotoxicity.
Schnaar et al., Baltimore, United States. In J Neurochem, 2011
This study suggested that MAG engages membrane-domain resident neuronal receptors to protect neurons from excitotoxicity, and that soluble MAG mitigates excitotoxic damage in vivo.
PirB is a functional receptor for myelin inhibitors of axonal regeneration.
Tessier-Lavigne et al., San Francisco, United States. In Science, 2008
Three proteins found in myelin--Nogo, MAG, and OMgp--inhibit axon regeneration in vitro and bind to the glycosylphosphatidylinositol-anchored Nogo receptor (NgR).
Axon-glial signaling and the glial support of axon function.
Trapp et al., Göttingen, Germany. In Annu Rev Neurosci, 2007
The underlying mechanisms are still poorly understood; we do know that to maintain axonal integrity, mammalian myelin-forming cells require the expression of some glia-specific proteins, including CNP, PLP, and MAG, as well as intact peroxisomes, none of which is necessary for myelin assembly.
Experience-driven plasticity of visual cortex limited by myelin and Nogo receptor.
Strittmatter et al., New Haven, United States. In Science, 2005
Thus, physiological NgR signaling from myelin-derived Nogo, MAG, and OMgp consolidates the neural circuitry established during experience-dependent plasticity.
F3/contactin acts as a functional ligand for Notch during oligodendrocyte maturation.
Xiao et al., Singapore, Singapore. In Cell, 2003
F3/Notch signaling promotes oligodendrocyte precursor cell differentiation and upregulates the myelin-related protein MAG in OLN-93 cells.
P75 interacts with the Nogo receptor as a co-receptor for Nogo, MAG and OMgp.
He et al., Boston, United States. In Nature, 2002
In inhibiting neurite outgrowth, several myelin components, including the extracellular domain of Nogo-A (Nogo-66), oligodendrocyte myelin glycoprotein (OMgp) and myelin-associated glycoprotein (MAG), exert their effects through the same Nogo receptor (NgR).
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