Molecular mechanisms of lipopolysaccharide-mediated inhibition of glutathione synthesis in mice.
Los Angeles, United States. In Free Radic Biol Med, 2014
The key mechanism was a decrease in sumoylation of nuclear factor-erythroid 2-related factor 2 (Nrf2) and MafG, which is required for their heterodimerization and subsequent binding and trans-activation of the antioxidant-response element (ARE) present in the promoter region of these genes that is essential for their expression.
The world according to Maf.
Tsukuba, Japan. In Nucleic Acids Res, 1997
The small Maf proteins (MafF, MafG and MafK), as do all family members, include a characteristic basic region linked to a leucine zipper (b-Zip) domain which mediate DNA binding and subunit dimerization respectively.