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V-maf musculoaponeurotic fibrosarcoma oncogene homolog F

MAFF, hMafF
The protein encoded by this gene is a basic leucine zipper (bZIP) transcription factor that lacks a transactivation domain. It is known to bind the US-2 DNA element in the promoter of the oxytocin receptor (OTR) gene and most likely heterodimerizes with other leucine zipper-containing proteins to enhance expression of the OTR gene during term pregnancy. The encoded protein can also form homodimers, and since it lacks a transactivation domain, the homodimer may act as a repressor of transcription. This gene may also be involved in the cellular stress response. Multiple transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2009] (from NCBI)
Top mentioned proteins: MAF, NF-E2, MafG, CAN, ACID
Papers on MAFF
Bioinformatics analyses of significant prognostic risk markers for thyroid papillary carcinoma.
New
Chang et al., Changsha, China. In Tumour Biol, Sep 2015
Among the 11 prognostic risk genes, v-maf avian musculoaponeurotic fibrosarcoma oncogene homologue F (MAFF), SRY (sex-determining region Y)-box 4 (SOX4), and retinoic acid receptor, alpha (RARA) encoded transcription factors.
Isolation and characterization of two mitoviruses and a putative alphapartitivirus from Fusarium spp.
New
Takehara et al., Fukuyama, Japan. In Virus Genes, Jun 2015
Thirty-seven Fusarium spp. at the MAFF collection were analyzed.
Mutant p53 gains new function in promoting inflammatory signals by repression of the secreted interleukin-1 receptor antagonist.
New
Bossi et al., Roma, Italy. In Oncogene, Jun 2015
Moreover, mutp53, but not wtp53, binds physically the sIL-1Ra promoter and the protein-protein interaction with the transcriptional co-repressor MAFF (v-MAF musculoaponeurotic fibrosarcoma oncogene family, protein F) is required for mutp53-induced sIL-1Ra suppression.
Inhibitor of differentiation proteins protect against oxidative stress by regulating the antioxidant-mitochondrial response in mouse beta cells.
New
Laybutt et al., Sydney, Australia. In Diabetologia, Apr 2015
ID1, ID3 and small MAF proteins (MAFF, MAFG and MAFK) were inhibited using small interfering RNA.
In vitro regeneration and Agrobacterium mediated genetic transformation of Artemisia aucheri Boiss.
Azadi et al., Zanjān, Iran. In Physiol Mol Biol Plants, 2014
Also, an efficient genetically transformed root induction for A. aucheri was developed through Agrobacterium rhizogenes-mediated transformation by four bacterial strains, A4, ATCC15834, MSU440, and A13 (MAFF-02-10266).
Small MAF genes variants and chronic myeloid leukemia.
Cordova et al., Mexico. In Eur J Haematol, 2014
After sequencing each MAF gene by Sanger technology, we found 17 variants in MAFF gene, eight in MAFG and seven in MAFK.
Real time live imaging of phytopathogenic bacteria Xanthomonas campestris pv. campestris MAFF106712 in 'plant sweet home'.
Ochiai et al., Tsukuba, Japan. In Plos One, 2013
campestris stocks in the MAFF collection, we selected XccMAFF106712 as a model compatible pathogen for the A. thaliana reference ecotype Columbia (Col-0).
Association between functional polymorphisms in genes involved in the MAPK signaling pathways and cutaneous melanoma risk.
Wei et al., Houston, United States. In Carcinogenesis, 2013
The risk associations with 16 SNPs around DUSP14 (rs1051849) and a previous reported melanoma locus MAFF/PLA2G6 (proxy SNP rs4608623) were replicated in the GenoMEL dataset (P < 0.01) but failed in the Australian dataset.
The small MAF transcription factors MAFF, MAFG and MAFK: current knowledge and perspectives.
Review
Blank et al., Montréal, Canada. In Biochim Biophys Acta, 2012
The small MAFs, MAFF, MAFG and MAFK have emerged as crucial regulators of mammalian gene expression.
Embryonic lethality and fetal liver apoptosis in mice lacking all three small Maf proteins.
GeneRIF
Yamamoto et al., Sendai, Japan. In Mol Cell Biol, 2012
MafF, MafG, and MafK triple-knockout mice developed normally until embryonic day 9.5 (E9.5). Thereafter, however, the triple-knockout embryos showed severe growth retardation and liver hypoplasia, and the embryos died around E13.5.
Arbuscular mycorrhizal fungal spores host bacteria that affect nutrient biodynamics and biocontrol of soil-borne plant pathogens.
Ishii et al., Kyoto, Japan. In Biol Open, 2012
lactucae MAFF 744088, Rosellinia necatrix, Rhizoctonia solani MAFF 237426, and Pythium ultimum NBRC 100123.
Establish a recombinant yeast detection system to study the effect of MIP on transactivation function of hMafF in US2-driven gene transcription.
GeneRIF
Chen et al., Zhanjiang, China. In J Microbiol Methods, 2009
Only in the presence of both MIP and hMafF could the nUS2-pLacZi reporter in yeast genome be activated.
Small Maf proteins in mammalian gene control: mere dimerization partners or dynamic transcriptional regulators?
Review
Blank, Montréal, Canada. In J Mol Biol, 2008
The small Maf basic leucine zipper (bZIP) proteins MafF, MafG and MafK, while modest in size, have emerged as crucial regulators of mammalian gene expression.
Regulation of oxytocin receptors and oxytocin receptor signaling.
Review
Thornton et al., Coventry, United Kingdom. In Semin Reprod Med, 2007
In the human uterus events are less clear, although a prominent role for inflammatory-related rapid-response genes and novel transcription factors such as hMafF (human homologue of chicken musculoaponeurotic fibrosarcoma oncogene family protein F) have been put forward.
The novel human gene MIP functions as a co-activator of hMafF.
GeneRIF
Lu et al., Shanghai, China. In Arch Biochem Biophys, 2006
Expression of hMafF or MIP alone did not alter basal reporter transcription activity, whereas co-expression of hMafF and MIP activated transcription efficiently.
Regulation of the MAFF transcription factor by proinflammatory cytokines in myometrial cells.
GeneRIF
Blank et al., Montréal, Canada. In Biol Reprod, 2006
In myometrial cells we observed an important induction by interleukin 1 beta and a weaker upregulation by tumor necrosis factor, whereas interleukin 6 treatment had no effect.
Genetic evidence that small maf proteins are essential for the activation of antioxidant response element-dependent genes.
GeneRIF
Yamamoto et al., Tsukuba, Japan. In Mol Cell Biol, 2005
mafG::mafK::mafF triple-mutant fibroblasts that completely lack small Mafs are highly susceptible to oxidative stress. (mafF)
Molecular regulation of the oxytocin receptor in peripheral organs.
Review
Murata et al., Ōsaka, Japan. In J Mol Endocrinol, 2003
The nuclear fractions from up-regulated (term myometrium) and down-regulated (non-pregnant myometrium) tIssues show differential patterns of protein binding to the 5'-flanking region, and a human homologue of chicken MafF has been cloned as a term-myometrium-specific oxytocin receptor modulator.
Factors influencing the carcinogenicity of food chemicals.
Review
Benford et al., Leicester, United Kingdom. In Toxicology, 1999
In recognition of these issues, the UK Ministry of Agriculture, Fisheries and Food (MAFF) is funding a number of projects aimed at providing greater mechanistic understanding of the links between food and cancer, in order to offer detailed advice to the public.
Regulation of transcription by dimerization of erythroid factor NF-E2 p45 with small Maf proteins.
Impact
Yamamoto et al., Sendai, Japan. In Nature, 1994
We show here that products of the maf proto-oncogene family, MafF, MafG and MafK (the small Maf proteins) which possess a b-zip DNA-binding domain but lack a canonical transactivation domain, directly control the DNA-binding properties of p45 by heterodimeric association with p45.
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