Alpha-cell dysfunctions and molecular alterations in male insulinopenic diabetic mice are not completely corrected by insulin.
Genève, Switzerland. In Endocrinology, Jan 2016
We identified genes coding for proteins involved in glucagon biosynthesis and secretion, α-cell differentiation and potential stress markers such as the glucagon, Arx, MafB, cMaf, Brain4, Foxa1, Foxa3, HNF4α, TCF7L2, Glut1, Sglt2, Cav2.1, Cav2.2, Nav1.7,
Towards an understanding of kidney diseases associated with WT1 mutations.
Jena, Germany. In Kidney Int, Oct 2015
WT1 controls metanephric mesenchyme (MM) self-renewal and proliferation mainly by regulating FGF and BMP-pSMAD signaling pathways as well as Sall1 and Pax2, encoding key transcription factors; WT1 drives MM differentiation and mesenchyme-epithelial transition by targeting Fgf8 and Wnt4; WT1 defines podocyte identity by activation of other podocyte-specific transcription factors, including Mafb, Lmx1b, FoxC2, and Tcf21.
Serum amyloid A inhibits RANKL-induced osteoclast formation.
Suwŏn, South Korea. In Exp Mol Med, 2014
SAA not only markedly blocked the expression of several osteoclast-associated genes (TNF receptor-associated factor 6 and osteoclast-associated receptor) but also strongly induced the expression of negative regulators (MafB and interferon regulatory factor 8).
MafA and MafB activity in pancreatic β cells.
Nashville, United States. In Trends Endocrinol Metab, 2011
Analyses in mouse models have revealed crucial roles for MafA (musculoaponeurotic fibrosarcoma oncogene family A) and MafB in islet β cells, with MafB being required during development and MafA in adults.