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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

V-maf musculoaponeurotic fibrosarcoma oncogene homolog

MAF, c-Maf
The protein encoded by this gene is a DNA-binding, leucine zipper-containing transcription factor that acts as a homodimer or as a heterodimer. Depending on the binding site and binding partner, the encoded protein can be a transcriptional activator or repressor. This protein plays a role in the regulation of several cellular processes, including embryonic lens fiber cell development, increased T-cell susceptibility to apoptosis, and chondrocyte terminal differentiation. Defects in this gene are a cause of juvenile-onset pulverulent cataract as well as congenital cerulean cataract 4 (CCA4). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2010] (from NCBI)
Top mentioned proteins: Tec, CAN, HAD, Nrf2, Insulin
Papers using MAF antibodies
Quantifying the role of aberrant somatic hypermutation in transformation of follicular lymphoma
Delabie Jan et al., In Journal of Hematopathology, 2007
... MAF-B (goat polyclonal)Santa Cruz Biotechnology ...
Papers on MAF
Genetic evidence that lower circulating FSH levels lengthen menstrual cycle, increase age at menopause and impact female reproductive health.
Murray et al., Exeter, United Kingdom. In Hum Reprod, Feb 2016
MAIN RESULTS AND THE ROLE OF CHANCE: The FSH-lowering T allele of the FSHB promoter polymorphism (rs10835638; MAF 0.16) was associated with longer menstrual cycles [0.16 SD (c. 1 day) per minor allele; 95% confidence interval (CI) 0.12-0.20;
Exome Array Analysis Identifies A Common Variant in IL27 Associated with Chronic Obstructive Pulmonary Disease.
NETT Genetics et al., Boston, United States. In Am J Respir Crit Care Med, Feb 2016
We evaluated single variants with a minor allele frequency (MAF) above 0.5% using logistic regression.
Quantitative genetics of circulating Dickkopf-related protein 1 (DKK1) in community-based sample of UK twins.
Livshits et al., Tel Aviv-Yafo, Israel. In Osteoporos Int, Feb 2016
Plasma samples were analysed for circulating levels of DKK1, IL-6 and fractalkine (FRCT); 65 SNPs of DKK1, IL-6 and FRCT candidate genes, with MAF >0.1, were examined.
Focused Analysis of Exome Sequencing Data for Rare Germline Mutations in Familial and Sporadic Lung Cancer.
Spitz et al., Houston, United States. In J Thorac Oncol, Jan 2016
The minor allele frequency (MAF) of this variant in the 1000 Genomes database is 0.0026.
The KDM3A-KLF2-IRF4 axis maintains myeloma cell survival.
Anderson et al., Boston, United States. In Nat Commun, Dec 2015
Importantly, silencing of KDM3A, KLF2 or IRF4 both decreases MM cell adhesion to bone marrow stromal cells and reduces MM cell homing to the bone marrow, in association with decreased ITGB7 expression in MAF-translocated MM cell lines.
Height-reducing variants and selection for short stature in Sardinia.
Cucca et al., Cagliari, Italy. In Nat Genet, Nov 2015
The other variant, in the imprinted KCNQ1 gene (minor allele frequency (MAF) = 7.7% in Sardinia versus <1% elsewhere) reduces height by an average of 1.83 cm (-0.31 s.d.) when maternally inherited.
Multiple functions of Maf in the regulation of cellular development and differentiation.
Guo et al., Changchun, China. In Diabetes Metab Res Rev, Nov 2015
Cellular muscular aponeurotic fibrosarcoma (c-Maf) is a member of the large macrophage-activating factor family.
Changing gears in Nrf1 research, from mechanisms of regulation to its role in disease and prevention.
Willmore et al., Ottawa, Canada. In Biochim Biophys Acta, Oct 2015
The "cap'n'collar" bZIP transcription factor Nrf1 heterodimerizes with small Maf proteins to bind to the Antioxidant Response Element/Electrophile Response Element to transactivate antioxidant enzyme, phase 2 detoxification enzyme and proteasome subunit gene expression.
Behind the scenes of vitamin D binding protein: More than vitamin D binding.
Speeckaert et al., Gent, Belgium. In Best Pract Res Clin Endocrinol Metab, Oct 2015
In this review, we will focus on the analytical aspects of the determination of DBP and discuss in detail the multifunctional capacity [actin scavenging, binding of fatty acids, chemotaxis, binding of endotoxins, influence on T cell response and influence of vitamin D binding protein-macrophage activating factor (DBP-MAF) on bone metabolism and cancer] of this abundant plasma protein.
Loss-of-function variants in ATM confer risk of gastric cancer.
Stefansson et al., Reykjavík, Iceland. In Nat Genet, Aug 2015
The combination of the loss-of-function variants p.Gln852*, p.Ser644* and p.Tyr103* (combined minor allele frequency (MAF) = 0.3%) also associates with pancreatic and prostate cancers (OR = 3.81 and 2.18, respectively) and gives an indication of risk of breast and colorectal cancers (OR = 1.82 and 1.97, respectively).
Appropriate therapy for type 2 diabetes mellitus in view of pancreatic β-cell glucose toxicity: "the earlier, the better".
Kaku et al., Ōsaka, Japan. In J Diabetes, Aug 2015
In the diabetic state, nuclear expression of the pancreatic transcription factors pancreatic and duodenal homeobox 1 (PDX-1) and v-Maf musculoaponeurotic fibrosarcoma oncogene family, protein A (MafA) is decreased.
The long intergenic noncoding RNA landscape of human lymphocytes highlights the regulation of T cell differentiation by linc-MAF-4.
Pagani et al., Milano, Italy. In Nat Immunol, Mar 2015
Expression of linc-MAF-4, a chromatin-associated lincRNA specific to the TH1 subset of helper T cells, was inversely correlated with expression of MAF, a TH2-associated transcription factor.
Harnessing the Therapeutic Potential of Th17 Cells.
Mageed et al., Arbīl, Iraq. In Mediators Inflamm, 2014
For development, Th17 cells require activation of the transcription factors STAT3 and RORγt while RUNX1, c-Maf, and Aiolos are involved in changes of phenotype/functions.
Genome-wide association analyses identify 18 new loci associated with serum urate concentrations.
Gieger et al., Freiburg, Germany. In Nat Genet, 2013
By combining data from >140,000 individuals of European ancestry within the Global Urate Genetics Consortium (GUGC), we identified and replicated 28 genome-wide significant loci in association with serum urate concentrations (18 new regions in or near TRIM46, INHBB, SFMBT1, TMEM171, VEGFA, BAZ1B, PRKAG2, STC1, HNF4G, A1CF, ATXN2, UBE2Q2, IGF1R, NFAT5, MAF, HLF, ACVR1B-ACVRL1 and B3GNT4).
Exome array analysis identifies new loci and low-frequency variants influencing insulin processing and secretion.
Mohlke et al., Ann Arbor, United States. In Nat Genet, 2013
To examine low-frequency (minor allele frequency (MAF) 0.5-5%) and rare (MAF < 0.5%) nonsynonymous variants, we analyzed exome array data in 8,229 nondiabetic Finnish males using the Illumina HumanExome Beadchip.
Tyrosine phosphorylation of c-Maf enhances the expression of IL-4 gene.
Miaw et al., Taipei, Taiwan. In J Immunol, 2012
this study sheds new light on the role of posttranslational modification of c-Maf in IL-4 production and Th cell-mediated autoimmune diseases.
Activation of the hedgehog signaling pathway in the developing lens stimulates ectopic FoxE3 expression and disruption in fiber cell differentiation.
West-Mays et al., Hamilton, Canada. In Invest Ophthalmol Vis Sci, 2012
inappropriate expression of the fiber cell markers c-maf and Prox1 also occurred, indicating a failure of appropriate lens fiber cell differentiation accompanied by altered lens cell proliferation and cell death.
c-Maf is required for the development of dorsal horn laminae III/IV neurons and mechanoreceptive DRG axon projections.
Cheng et al., Shanghai, China. In J Neurosci, 2012
This study demonistrated that c-Maf is required for the development of dorsal horn laminae III/IV neurons and mechanoreceptive DRG axon projections.
Bcl6 and Maf cooperate to instruct human follicular helper CD4 T cell differentiation.
Crotty et al., Los Angeles, United States. In J Immunol, 2012
Bcl6 and Maf collaborate to orchestrate a suite of genes that define core characteristics of human Tfh cell biology.
The transcription factor c-Maf controls touch receptor development and function.
Birchmeier et al., Berlin, Germany. In Science, 2012
findings show that the transcription factor c-Maf/c-MAF is crucial for mechanosensory function
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