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Mucosal vascular addressin cell adhesion molecule 1

MAdCAM-1, mucosal addressin cell adhesion molecule-1
The protein encoded by this gene is an endothelial cell adhesion molecule that interacts preferentially with the leukocyte beta7 integrin LPAM-1 (alpha4beta7), L-selectin, and VLA-4 (alpha4beta1) on myeloid cells to direct leukocytes into mucosal and inflamed tissues. It is a member of the immunoglobulin family and is similar to ICAM1 and VCAM1. At least seven alternatively spliced transcripts encoding different protein isoforms have been found for this gene, but the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008] (from NCBI)
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Top mentioned proteins: Vascular Cell Adhesion Molecule-1, Intercellular Adhesion Molecule-1, CAN, L-selectin, V1a
Papers on MAdCAM-1
Evidence that β7 Integrin Regulates Hematopoietic Stem Cell Homing and Engraftment Through Interaction with MAdCAM-1.
New
Chen et al., Xi'an, China. In Stem Cells Dev, Feb 2016
Lethal irradiation induced expression of the α4β7 integrin ligand-mucosal addressin cell adhesion molecule-1 (MAdCAM-1) on BM endothelial cells.
Dynamic patterns of clonal evolution in tumor vasculature underlie alterations in lymphocyte-endothelial recognition to foster tumor immune escape.
New
Weissman et al., Stanford, United States. In Cancer Res, Jan 2016
Furthermore, we show a developmental switch in the expression of functionally significant primary lymphocyte adhesion molecules on tumor endothelium, such as the loss in expression of the mucosal addressin MAdCAM-1-whose counter receptor a4β7 on lymphocytes controls lymphocyte homing.
Norisoboldine ameliorates DSS-induced ulcerative colitis in mice through induction of regulatory T cells in colons.
New
Wei et al., Nanjing, China. In Int Immunopharmacol, Dec 2015
On the other hand, NOR did not affect the expressions of homing receptors CCR9 and α4β7 in SPs, and homing ligands CCL25 and Madcam-1 in MLNs and colonic LPs, suggesting that the increase of Treg cells in colons by NOR was not due to gut homing.
Strategies that target leukocyte traffic in inflammatory bowel diseases: recent developments.
Review
New
Rivera-Nieves, San Diego, United States. In Curr Opin Gastroenterol, Nov 2015
RECENT FINDINGS: We discuss the most important findings of one published phase II trial that targeted the β7 integrin (etrolizumab), two phase II trials that targeted the α4β7 integrin ligand: mucosal addressin cell adhesion molecule 1 (MAdCAM-1, PF-00547659), a phase II trial targeting the chemokine IP-10 (CXCL10) in Crohn's, and a phase II trial that targeted the sphingosine-1-phosphate receptor-1: ozanimod in patients with ulcerative colitis.
Dual functions of Rap1 are crucial for T-cell homeostasis and prevention of spontaneous colitis.
Katagiri et al., Sagamihara, Japan. In Nat Commun, 2014
Here we show that Rap1-GDP restrains rolling behaviours of T cells on the peripheral lymph node addressin (PNAd), P-selectin and mucosal addressin cell adhesion molecule-1 (MadCAM-1) by inhibiting tether formation.
Identification of New Regions in HIV-1 gp120 Variable 2 and 3 Loops that Bind to α4β7 Integrin Receptor.
Rao et al., Bethesda, United States. In Plos One, 2014
RESULTS: We demonstrate that α4β7 on RPMI8866 cells bound specifically to its natural ligand mucosal addressin cell adhesion molecule-1 (MAdCAM-1) as well as to cyclic-V2 and cyclic-V3 peptides.
Innate lymphoid cells integrate stromal and immunological signals to enhance antibody production by splenic marginal zone B cells.
Impact
Cerutti et al., Barcelona, Spain. In Nat Immunol, 2014
Splenic ILCs established bidirectional crosstalk with MAdCAM-1(+) marginal reticular cells by providing tumor-necrosis factor (TNF) and lymphotoxin, and they stimulated MZ B cells via B cell-activation factor (BAFF), the ligand of the costimulatory receptor CD40 (CD40L) and the Notch ligand Delta-like 1 (DLL1).
Review article: anti-adhesion therapies for inflammatory bowel disease.
Review
Rutgeerts et al., Leuven, Belgium. In Aliment Pharmacol Ther, 2014
RESULTS: A total of eight drugs were found including those targeting the α4β1, α4β7 or αEβ7 integrins as well as the ICAM-1 and MAdCAM-1 addressins and the chemokine receptor 9. The rationale for these drugs is the blockade of gut-homing T lymphocytes and the ones targeting the α4β7/MAdCAM-1 interaction presented the most promising results in luminal disease.
New targets for mucosal healing and therapy in inflammatory bowel diseases.
Review
Neurath, Erlangen, Germany. In Mucosal Immunol, 2014
In addition, blockade of T-cell homing via the integrins α4β7 and the addressin mucosal vascular addressin cell adhesion molecule 1 (MAdCAM-1) emerges as a promising new approach for IBD therapy.
Effect of dietary fat on intestinal inflammatory diseases.
Review
Miura et al., Tokorozawa, Japan. In J Gastroenterol Hepatol, 2013
Enhanced infiltration of leukocytes and expression of mucosal addressin cell adhesion molecule-1 in intestinal mucosa was significantly decreased by omega-3 fat-rich diets treatment.
Vedolizumab for the treatment of IBD: a selective therapeutic approach targeting pathogenic a4b7 cells.
Review
Danese et al., Milano, Italy. In Curr Drug Targets, 2013
The α4β7 - integrin and its ligand, the MadCAM-1, have been of special interest, since they are found exclusively on the gut-homing lymphocyte subpopulations and in the intestinal mucosa respectively.
An integrin alpha4beta7•IgG heterodimeric chimera binds to MAdCAM-1 on high endothelial venules in gut-associated lymphoid tissue.
GeneRIF
Nakayama et al., Matsumoto, Japan. In J Histochem Cytochem, 2011
findings indicate that alpha4beta7*IgG can be used as a probe for functional MAdCAM-1 expressed on HEVs in GALT and could potentially serve as an anti-inflammatory drug inhibiting GALT-specific lymphocyte migration
The CC' and DE loops in Ig domains 1 and 2 of MAdCAM-1 play different roles in MAdCAM-1 binding to low- and high-affinity integrin alpha4beta7.
GeneRIF
Chen et al., Shanghai, China. In J Biol Chem, 2011
Findings suggest that the inactive alpha4beta7 and alpha4beta7 activated by different stimuli have distinct conformations with different structural requirements for MAdCAM-1 binding.
TET inducible expression of the α4β7-integrin ligand MAdCAM-1 on the blood-brain barrier does not influence the immunopathogenesis of experimental autoimmune encephalomyelitis.
GeneRIF
Engelhardt et al., Bern, Switzerland. In Eur J Immunol, 2011
ectopic expression of MAdCAM-1 at the BBB does not increase alpha4beta7-integrin-mediated immune cell trafficking into the CNS during MOG(aa35-55)-induced experimental autoimmune encephalomyelitis
Lactobacillus plantarum prevents the upregulation of adhesion molecule expression in an experimental colitis model.
GeneRIF
Qin et al., Shanghai, China. In Dig Dis Sci, 2010
Observed a significant decrease in expression of ICAM-1 and MAdCAM-1 mRNA/protein in lactobacillus plantarum treated colitis.
Blockage of angiotensin II type 1 receptor regulates TNF-alpha-induced MAdCAM-1 expression via inhibition of NF-kappaB translocation to the nucleus and ameliorates colitis.
GeneRIF
Joh et al., Nagoya, Japan. In Am J Physiol Gastrointest Liver Physiol, 2010
results suggest that AT1R regulates the expression of MAdCAM-1 under colonic inflammatory conditions through regulation of the translocation of NF-kappaB into the nucleus
The lymphotoxin LTalpha(1)beta(2) controls postnatal and adult spleen marginal sinus vascular structure and function.
Impact
Chaplin et al., Saint Louis, United States. In Immunity, 2009
We showed here that, in early postnatal lymphotoxin-deficient mice, the developing Flk-1+ white pulp vessels failed to organize or upregulate MAdCAM-1, leading to altered spatial rearrangement of both the white pulp endothelial cells and the smooth muscle actin-expressing cells.
Peyer's patch is the essential site in initiating murine acute and lethal graft-versus-host reaction.
Impact
GeneRIF
Matsushima et al., Tokyo, Japan. In Nat Immunol, 2003
acute-graft vs host reaction was prevented when recruitment of donor T cells into Peyer's patches was interrupted by disrupting the gene encoding chemokine receptor CCR5 or by blocking integrin alpha(4)beta(7)-MAdCAM-1 interactions
A novel, high endothelial venule-specific sulfotransferase expresses 6-sulfo sialyl Lewis(x), an L-selectin ligand displayed by CD34.
Impact
Fukuda et al., Los Angeles, United States. In Immunity, 1999
We herein describe a novel L-selectin ligand sulfotransferase, termed LSST, that directs the synthesis of the 6-sulfo sialyl Lewis(x) on L-selectin counterreceptors CD34, GlyCAM-1, and MAdCAM-1.
Developing lymph nodes collect CD4+CD3- LTbeta+ cells that can differentiate to APC, NK cells, and follicular cells but not T or B cells.
Impact
Weissman et al., Amsterdam, Netherlands. In Immunity, 1997
For a brief period during fetal lymph node organogenesis in mice, lymph node postcapillary high endothelial venules surprisingly express the Peyer's patch addressin MAdCAM-1.
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