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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

MAD3 Mad3p

Mad3, Mad3p
This gene encodes a member of the Myc superfamily of basic helix-loop-helix leucine zipper transcriptional regulators. The encoded protein forms a heterodimer with the cofactor MAX which binds specific E-box DNA motifs in the promoters of target genes and regulates their transcription. Disruption of the MAX-MXD3 complex is associated with uncontrolled cell proliferation and tumorigenesis. Transcript variants of this gene encoding different isoforms have been described.[provided by RefSeq, Dec 2008] (from NCBI)
Papers on Mad3
Kinase activity of fission yeast Mph1 is required for Mad2 and Mad3 to stably bind the anaphase promoting complex.
GeneRIF
Hardwick et al., Edinburgh, United Kingdom. In Curr Biol, 2012
A kinase-dead allele of the fission yeast MPS1 homolog (Mph1) is checkpoint defective and levels of anaphase promoting complex-associated Mad2 and Mad3 are dramatically reduced in this mutant.
Mad2 and Mad3 cooperate to arrest budding yeast in mitosis.
GeneRIF
Murray et al., Cambridge, United States. In Curr Biol, 2012
Mad3 is required for the stable binding of Mad2 to Cdc20 in vivo, which is sufficient to inhibit APC activity and is the most downstream event in spindle checkpoint activation.
Mad3 negatively regulates B cell differentiation in the spleen by inducing Id2 expression.
GeneRIF
Shachar et al., Israel. In Mol Biol Cell, 2010
Results demonstrate that high expression levels of Mad3 in immature B cells induce Id2 expression, which inhibits transcription of genes essential for B cell differentiation.
Adenosine signaling mediates SUMO-1 modification of IkappaBalpha during hypoxia and reoxygenation.
GeneRIF
Ibla et al., Boston, United States. In J Biol Chem, 2009
Adenosine signaling mediates SUMO-1 modification of IkappaBalpha during hypoxia and reoxygenation.
The spindle checkpoint functions of Mad3 and Mad2 depend on a Mad3 KEN box-mediated interaction with Cdc20-anaphase-promoting complex (APC/C).
GeneRIF
Hardwick et al., Edinburgh, United Kingdom. In J Biol Chem, 2008
the Mad3 KEN box is a critical mediator of Cdc20-APC/C inhibition, without which neither Mad3 nor Mad2 can associate with the APC/C or inhibit anaphase onset
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