A role of WT1 in cell division and genomic stability.
Buffalo, United States. In Cell Cycle, 2014
Recently we have found that WT1 can regulate the fidelity of chromosome segregation through its interaction with the spindle assembly checkpoint protein, Mitotic arrest deficient-2 (MAD2).
MAX and MYC: a heritable breakup.
Madrid, Spain. In Cancer Res, 2012
This finding also confirms the importance of impairment of the MYC/MAX/MXD1 axis in the development of aggressive neural tumors, because MYCN overexpression is an established genetic hallmark of malign neuroblastoma, and it is likely that MXI1 plays a relevant role in the development of medulloblastoma and glioblastoma.
Caspase-independent mitotic death (CIMD).
Memphis, United States. In Cell Cycle, 2008
In BUB1-deficient (but not MAD2-deficient) cells, CIMD is induced by conditions that activate the spindle checkpoint (i.e., cold shock or treatment with nocodazole, paclitaxel or 17-AAG [17-allylaminogeldanamycin]).
Taxanes, microtubules and chemoresistant breast cancer.
Dublin, Ireland. In Biochim Biophys Acta, 2008
Since spindle microtubules are the primary drug targets for taxanes, important SAC proteins such as MAD2, BUBR1, Synuclein-gamma and Aurora A have emerged as potentially important predictive markers of taxane resistance, as have specific checkpoint proteins such as BRCA1.
Flies without a spindle checkpoint.
Gif-sur-Yvette, France. In Nat Cell Biol, 2007
Mad2 has a key role in the spindle-assembly checkpoint (SAC) - the mechanism delaying anaphase onset until all chromosomes correctly attach to the spindle.