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Macrophage migration inhibitory factor

macrophage migration inhibitory factor, GIF
This gene encodes a lymphokine involved in cell-mediated immunity, immunoregulation, and inflammation. It plays a role in the regulation of macrophage function in host defense through the suppression of anti-inflammatory effects of glucocorticoids. This lymphokine and the JAB1 protein form a complex in the cytosol near the peripheral plasma membrane, which may indicate an additional role in integrin signaling pathways. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, HAD, Interleukin-6, V1a, ACID
Papers using macrophage migration inhibitory factor antibodies
Direct association of thioredoxin-1 (TRX) with macrophage migration inhibitory factor (MIF): regulatory role of TRX on MIF internalization and signaling
Supplier
Hofer Stefan et al., In Mediators of Inflammation, 2008
... R&D Systems, Minneapolis, MN, USA), Human Thioredoxin-1 (Human TRX1, LabFrontier Co., Ltd, Seoul, Korea), and Macrophage Migration Inhibitory Factor (Human MIF, RayBiotech, Inc., Norcross, GA, USA) ...
Papers on macrophage migration inhibitory factor
Macrophage Migration Inhibitory Factor-CXCR4 Is the Dominant Chemotactic Axis in Human Mesenchymal Stem Cell Recruitment to Tumors.
New
Janes et al., London, United Kingdom. In J Immunol, 23 Mar 2015
In this study, we discover a novel role for macrophage migration inhibitory factor (MIF) as the key director of MSC migration and infiltration toward tumor cells.
Improved survival of mesenchymal stem cells by macrophage migration inhibitory factor.
New
Hou et al., Wenzhou, China. In Mol Cell Biochem, 21 Mar 2015
UNASSIGNED: Macrophage migration inhibitory factor (MIF) is a critical inflammatory cytokine that was recently associated with progenitor cell survival and potently inhibits apoptosis.
Design, Synthesis, and Protein Crystallography of Biaryltriazoles as Potent Tautomerase Inhibitors of Macrophage Migration Inhibitory Factor.
New
Jorgensen et al., New Haven, United States. In J Am Chem Soc, 20 Mar 2015
UNASSIGNED: Optimization is reported for biaryltriazoles as inhibitors of the tautomerase activity of human macrophage migration inhibitory factor (MIF), a proinflammatory cytokine associated with numerous inflammatory diseases and cancer.
Expression of Human Tissue Factor Pathway Inhibitor on Vascular Smooth Muscle Cells Inhibits Secretion of Macrophage Migration Inhibitory Factor and Attenuates Atherosclerosis in ApoE-/- Mice.
New
Dorling et al., London, United Kingdom. In Circulation, 12 Mar 2015
The small lipid-rich lesions that developed had markedly reduced leukocyte infiltrates and, in contrast to ApoE(-/-) mice, SMC did not express macrophage migratory inhibitory factor (MIF), including at sites distant from atheromatous lesions.
Lymphocyte migration into atherosclerotic plaque.
Review
New
Ley et al., Los Angeles, United States. In Arterioscler Thromb Vasc Biol, 31 Jan 2015
We review evidence for involvement of the chemokines CCL5, CCL19, CCL21, CXCL10, and CXCL16 and macrophage migration inhibitory factor in lymphocyte homing in atherosclerosis.
[Macrophage migration inhibitory factor and its relationship with obesity and diabetes].
Review
New
Parra-Rojas et al., In Invest Clin, Sep 2014
The macrophage migration inhibitory factor (MIF), is a proinflammatory cytokine involved in autoimmune and inflammatory diseases.
Isolation and molecular characterization of contagious pustular dermatitis virus from Rajasthan, India.
Maan et al., Hisār, India. In Virusdisease, 2013
The virus was isolated in Vero cell cultures from scab and swab suspensions and has been identified using GIF/IL-2 and B2L gene specific primers in PCR and sequencing.
Influence of molecular genetics in Vogt-Koyanagi-Harada disease.
Review
Pang et al., Hong Kong, Hong Kong. In J Ophthalmic Inflamm Infect, 2013
Genes which might be involved in the pathogenesis of VKH disease included genes expressing HLA, complement factor H, interleukins, cytotoxic T-lymphocyte antigen 4 (CTLA-4), killer cell immunoglobulin-like receptors (KIR), programmed cell death 1 (PDCD1), protein tyrosine phosphatase non-receptor 22 (PTPN22), osteopontin, tumor necrosis factor alpha-induced protein 3 (TNFAIP3), macrophage migration inhibitory factor (MIF), and other immune response genes.
The CXCL12/CXCR4 chemokine ligand/receptor axis in cardiovascular disease.
Review
Noels et al., München, Germany. In Front Physiol, 2013
Although the CXCL12/CXCR4 interaction has long been regarded as a monogamous relation, the identification of the pro-inflammatory chemokine macrophage migration inhibitory factor (MIF) as an important second ligand for CXCR4, and of CXCR7 as an alternative receptor for CXCL12, has undermined this interpretation and has considerably complicated the understanding of CXCL12/CXCR4 signaling and associated biological functions.
Cytokine patterns in patients with cancer: a systematic review.
Review
Impact
Lippitz, Stockholm, Sweden. In Lancet Oncol, 2013
In this Review of published clinical studies of patients with cancer, expression and interplay of the following cytokines are examined: interleukin 2, interleukin 6, interleukin 8, interleukin 10, interleukin 12, interleukin 18, tumour necrosis factor α (TNFα), transforming growth factor β (TGFβ), interferon-γ, HLA-DR, macrophage migration inhibitory factor (MIF), and C-X-C motif chemokine receptor 4 (CXCR4).
A novel allosteric inhibitor of macrophage migration inhibitory factor (MIF).
GeneRIF
Anthony et al., New Haven, United States. In J Biol Chem, 2012
p425 blocked the interaction of MIF with its receptor, CD74, and interfered with the pro-inflammatory activities of the cytokine.
Macrophage migration inhibitory factor covalently complexed with phenethyl isothiocyanate.
GeneRIF
Wilbanks et al., Dunedin, New Zealand. In Acta Crystallogr Sect F Struct Biol Cryst Commun, 2012
structure of the modified MIF obtained from X-ray diffraction data to 1.64 A resolution is presented
Macrophage migration inhibitory factor is involved in a positive feedback loop increasing aromatase expression in endometriosis.
GeneRIF
Akoum et al., Québec, Canada. In Am J Pathol, 2012
The present study revealed the existence of a local positive feedback loop by which estrogen acts directly on ectopic endometrial cells to upregulate the expression of MIF, which, in turn, displays the capability of inducing the expression of aromatase.
Overview of Macrophage Migration Inhibitory Factor (MIF) as a Potential Biomarker Relevant to Adiposity.
Review
Sakaue et al., Ebetsu, Japan. In J Tradit Complement Med, 2012
The cytokine "macrophage migration inhibitory factor (MIF)" is generally recognized as a proinflammatory cytokine, and MIF is involved in broad range of acute and chronic inflammatory states.
Macrophage migration inhibitory factor antagonist blocks the development of endometriosis in vivo.
GeneRIF
Akoum et al., Québec, Canada. In Plos One, 2011
Specific inhibition of MIF alters endometriotic tissue growth and progression in vivo and may represent a promising potential therapeutic avenue for endometriosis.
Macrophage migration inhibitory factor is enhanced in acute coronary syndromes and is associated with the inflammatory response.
GeneRIF
Geisler et al., Tübingen, Germany. In Plos One, 2011
Study demonstrated enhanced expression of macrophage migration inhibitory factor in acute coronary syndromes.
Dual nature of the adaptive immune system in lampreys.
Impact
Cooper et al., Atlanta, United States. In Nature, 2009
Conversely, VLRA lymphocytes respond preferentially to a classical T-cell mitogen and upregulate the expression of the pro-inflammatory cytokine genes interleukin-17 (IL-17) and macrophage migration inhibitory factor (MIF).
Glucocorticoid resistance in inflammatory diseases.
Review
Impact
Adcock et al., London, United Kingdom. In Lancet, 2009
Several molecular mechanisms of glucocorticoid resistance have now been identified, including activation of mitogen-activated protein (MAP) kinase pathways by certain cytokines, excessive activation of the transcription factor activator protein 1, reduced histone deacetylase-2 (HDAC2) expression, raised macrophage migration inhibitory factor, and increased P-glycoprotein-mediated drug efflux.
Macrophage migration inhibitory factor stimulates AMP-activated protein kinase in the ischaemic heart.
Impact
GeneRIF
Young et al., New Haven, United States. In Nature, 2008
macrophage migration inhibitory factor (MIF), an upstream regulator of inflammation, is released in the ischaemic heart, where it stimulates AMPK activation through CD74, promotes glucose uptake and protects the heart during ischaemia-reperfusion injury
MIF is a noncognate ligand of CXC chemokine receptors in inflammatory and atherogenic cell recruitment.
Impact
GeneRIF
Weber et al., Aachen, Germany. In Nat Med, 2007
By activating CXCR2 and CXCR4, MIF displays chemokine-like functions and acts as a major regulator of inflammatory cell recruitment and atherogenesis.
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