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Macrophage migration inhibitory factor

macrophage migration inhibitory factor, GIF
This gene encodes a lymphokine involved in cell-mediated immunity, immunoregulation, and inflammation. It plays a role in the regulation of macrophage function in host defense through the suppression of anti-inflammatory effects of glucocorticoids. This lymphokine and the JAB1 protein form a complex in the cytosol near the peripheral plasma membrane, which may indicate an additional role in integrin signaling pathways. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, HAD, Interleukin-6, V1a, ACID
Papers using macrophage migration inhibitory factor antibodies
Direct association of thioredoxin-1 (TRX) with macrophage migration inhibitory factor (MIF): regulatory role of TRX on MIF internalization and signaling
Supplier
Hofer Stefan et al., In Mediators of Inflammation, 2008
... R&D Systems, Minneapolis, MN, USA), Human Thioredoxin-1 (Human TRX1, LabFrontier Co., Ltd, Seoul, Korea), and Macrophage Migration Inhibitory Factor (Human MIF, RayBiotech, Inc., Norcross, GA, USA) ...
Papers on macrophage migration inhibitory factor
The Macrophage Migration Inhibitory Factor -173G/C gene polymorphism increase the risk of renal disease: A meta-analysis.
New
Fan et al., Chengdu, China. In Nephrology (carlton), 20 Nov 2014
AIM: Macrophage migration inhibitory factor (MIF) -173G/C (rs755622) gene polymorphism has been implicated the association with renal disease risk.
Biochemical and Hematologic Manifestations of Gastric Intrinsic Factor (GIF) Deficiency: A Treatable Cause of B12 Deficiency in the Old Order Mennonite Population of Southwestern Ontario.
New
Prasad et al., London, Canada. In Jimd Rep, 12 Nov 2014
UNLABELLED: Intrinsic factor deficiency (OMIM #261000, IFD) is a rare inherited disorder of vitamin B12 metabolism due to mutations in the gastric intrinsic factor (GIF) gene.We report three individuals from an Old Order Mennonite community who presented with B12 deficiency.
Role of MIF in myocardial ischaemia and infarction: insight from recent clinical and experimental findings.
Review
New
Du et al., In Clin Sci (lond), Aug 2014
First discovered in 1966 as an inflammatory cytokine, MIF (macrophage migration inhibitory factor) has been extensively studied for its pivotal role in a variety of inflammatory diseases, including rheumatoid arthritis and atherosclerosis.
Glucocorticoids and macrophage migration inhibitory factor (MIF) are neuroendocrine modulators of inflammation and neuropathic pain after spinal cord injury.
Review
New
Popovich et al., Columbus, United States. In Semin Immunol, May 2014
The relatively recent discovery that macrophage migration inhibitory factor (MIF) is produced throughout the body and can override the anti-inflammatory effects of GCs may provide unique insight to the importance of endogenous and exogenous GCs after SCI.
Mass Spectrometric Immunoassay for the qualitative and quantitative analysis of the cytokine Macrophage Migration Inhibitory Factor (MIF).
New
Nedelkov et al., Tempe, United States. In Proteome Sci, Dec 2013
BACKGROUND: The cytokine MIF (Macrophage Migration Inhibitory Factor) has diverse physiological roles and is present at elevated concentrations in numerous disease states.
The CXCL12/CXCR4 chemokine ligand/receptor axis in cardiovascular disease.
Review
New
Noels et al., München, Germany. In Front Physiol, Dec 2013
Although the CXCL12/CXCR4 interaction has long been regarded as a monogamous relation, the identification of the pro-inflammatory chemokine macrophage migration inhibitory factor (MIF) as an important second ligand for CXCR4, and of CXCR7 as an alternative receptor for CXCL12, has undermined this interpretation and has considerably complicated the understanding of CXCL12/CXCR4 signaling and associated biological functions.
Influence of molecular genetics in Vogt-Koyanagi-Harada disease.
Review
New
Pang et al., Hong Kong, Hong Kong. In J Ophthalmic Inflamm Infect, Dec 2013
Genes which might be involved in the pathogenesis of VKH disease included genes expressing HLA, complement factor H, interleukins, cytotoxic T-lymphocyte antigen 4 (CTLA-4), killer cell immunoglobulin-like receptors (KIR), programmed cell death 1 (PDCD1), protein tyrosine phosphatase non-receptor 22 (PTPN22), osteopontin, tumor necrosis factor alpha-induced protein 3 (TNFAIP3), macrophage migration inhibitory factor (MIF), and other immune response genes.
Comparison of inflammation, arterial stiffness and traditional cardiovascular risk factors between rheumatoid arthritis and inflammatory bowel disease.
New
Dart et al., Melbourne, Australia. In J Inflamm (lond), Dec 2013
Circulating markers (macrophage migration inhibitory factor, tumour necrosis factor-α, CRP, and vWF) were significantly associated with baPWV.
Macrophage migration inhibitory factor is involved in ectopic endometrial tissue growth and peritoneal-endometrial tissue interaction in vivo: a plausible link to endometriosis development.
New
Akoum et al., Québec, Canada. In Plos One, Dec 2013
A major pro-inflammatory factors found elevated in peritoneal fluid of women with endometriosis and to be overexpressed in peritoneal fluid macrophages and active, highly vascularized and early stage endometriotic lesions, macrophage migration inhibitory factor (MIF) appeared to induce angiogenic and inflammatory and estrogen producing phenotypes in endometriotic cells in vitro and to be a possible therapeutic target in vivo.
Cytokine patterns in patients with cancer: a systematic review.
Review
New
Impact
Lippitz, Stockholm, Sweden. In Lancet Oncol, May 2013
In this Review of published clinical studies of patients with cancer, expression and interplay of the following cytokines are examined: interleukin 2, interleukin 6, interleukin 8, interleukin 10, interleukin 12, interleukin 18, tumour necrosis factor α (TNFα), transforming growth factor β (TGFβ), interferon-γ, HLA-DR, macrophage migration inhibitory factor (MIF), and C-X-C motif chemokine receptor 4 (CXCR4).
A novel allosteric inhibitor of macrophage migration inhibitory factor (MIF).
GeneRIF
Anthony et al., New Haven, United States. In J Biol Chem, 2012
p425 blocked the interaction of MIF with its receptor, CD74, and interfered with the pro-inflammatory activities of the cytokine.
Macrophage migration inhibitory factor covalently complexed with phenethyl isothiocyanate.
GeneRIF
Wilbanks et al., Dunedin, New Zealand. In Acta Crystallogr Sect F Struct Biol Cryst Commun, 2012
structure of the modified MIF obtained from X-ray diffraction data to 1.64 A resolution is presented
Macrophage migration inhibitory factor is involved in a positive feedback loop increasing aromatase expression in endometriosis.
GeneRIF
Akoum et al., Québec, Canada. In Am J Pathol, 2012
The present study revealed the existence of a local positive feedback loop by which estrogen acts directly on ectopic endometrial cells to upregulate the expression of MIF, which, in turn, displays the capability of inducing the expression of aromatase.
Overview of Macrophage Migration Inhibitory Factor (MIF) as a Potential Biomarker Relevant to Adiposity.
Review
Sakaue et al., Ebetsu, Japan. In J Tradit Complement Med, 2012
The cytokine "macrophage migration inhibitory factor (MIF)" is generally recognized as a proinflammatory cytokine, and MIF is involved in broad range of acute and chronic inflammatory states.
Macrophage migration inhibitory factor antagonist blocks the development of endometriosis in vivo.
GeneRIF
Akoum et al., Québec, Canada. In Plos One, 2011
Specific inhibition of MIF alters endometriotic tissue growth and progression in vivo and may represent a promising potential therapeutic avenue for endometriosis.
Macrophage migration inhibitory factor is enhanced in acute coronary syndromes and is associated with the inflammatory response.
GeneRIF
Geisler et al., Tübingen, Germany. In Plos One, 2011
Study demonstrated enhanced expression of macrophage migration inhibitory factor in acute coronary syndromes.
Dual nature of the adaptive immune system in lampreys.
Impact
Cooper et al., Atlanta, United States. In Nature, 2009
Conversely, VLRA lymphocytes respond preferentially to a classical T-cell mitogen and upregulate the expression of the pro-inflammatory cytokine genes interleukin-17 (IL-17) and macrophage migration inhibitory factor (MIF).
Glucocorticoid resistance in inflammatory diseases.
Review
Impact
Adcock et al., London, United Kingdom. In Lancet, 2009
Several molecular mechanisms of glucocorticoid resistance have now been identified, including activation of mitogen-activated protein (MAP) kinase pathways by certain cytokines, excessive activation of the transcription factor activator protein 1, reduced histone deacetylase-2 (HDAC2) expression, raised macrophage migration inhibitory factor, and increased P-glycoprotein-mediated drug efflux.
Macrophage migration inhibitory factor stimulates AMP-activated protein kinase in the ischaemic heart.
Impact
GeneRIF
Young et al., New Haven, United States. In Nature, 2008
macrophage migration inhibitory factor (MIF), an upstream regulator of inflammation, is released in the ischaemic heart, where it stimulates AMPK activation through CD74, promotes glucose uptake and protects the heart during ischaemia-reperfusion injury
MIF is a noncognate ligand of CXC chemokine receptors in inflammatory and atherogenic cell recruitment.
Impact
GeneRIF
Weber et al., Aachen, Germany. In Nat Med, 2007
By activating CXCR2 and CXCR4, MIF displays chemokine-like functions and acts as a major regulator of inflammatory cell recruitment and atherogenesis.
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