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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 15 Apr 2015.

Macrophage migration inhibitory factor

macrophage migration inhibitory factor, GIF
This gene encodes a lymphokine involved in cell-mediated immunity, immunoregulation, and inflammation. It plays a role in the regulation of macrophage function in host defense through the suppression of anti-inflammatory effects of glucocorticoids. This lymphokine and the JAB1 protein form a complex in the cytosol near the peripheral plasma membrane, which may indicate an additional role in integrin signaling pathways. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: HAD, CAN, Interleukin-6, V1a, ACID
Papers using macrophage migration inhibitory factor antibodies
Direct association of thioredoxin-1 (TRX) with macrophage migration inhibitory factor (MIF): regulatory role of TRX on MIF internalization and signaling
Supplier
Hofer Stefan et al., In Mediators of Inflammation, 2008
... R&D Systems, Minneapolis, MN, USA), Human Thioredoxin-1 (Human TRX1, LabFrontier Co., Ltd, Seoul, Korea), and Macrophage Migration Inhibitory Factor (Human MIF, RayBiotech, Inc., Norcross, GA, USA) ...
Papers on macrophage migration inhibitory factor
Associations between Intensity of RRT, Inflammatory Mediators, and Outcomes.
New
Biological Markers of Recovery for the Kidney (BioMaRK) Study Investigators et al., Albuquerque, United States. In Clin J Am Soc Nephrol, 10 May 2015
Plasma inflammatory (IL-6, IL-8, IL-10, IL-18, and macrophage migration inhibitory factor) and apoptosis (TNF receptor-I [TNFR-I], TNFR-II, and death receptor-5) biomarkers on days 1 and 8 were examined after initiation of intensive RRT.
Macrophage Migration Inhibitory Factor, the Zelig of Cytokines, Is a Chaperone for SOD1 in Non-Neuronal Cells.
New
Ransohoff, Cambridge, United States. In Neuron, 08 May 2015
This chaperone is identified as the pleiotropic cytokine macrophage migration inhibitory factor.
Macrophage Migration Inhibitory Factor Deficiency Causes Prolonged Hearing Loss After Acoustic Overstimulation.
New
Nishizaki et al., Okayama, Japan. In Otol Neurotol, 07 May 2015
METHODS: Macrophage migration inhibitory factor-deficient mice (MIF mice) were used in this study.
Lymphocyte migration into atherosclerotic plaque.
Review
New
Ley et al., Los Angeles, United States. In Arterioscler Thromb Vasc Biol, Jan 2015
We review evidence for involvement of the chemokines CCL5, CCL19, CCL21, CXCL10, and CXCL16 and macrophage migration inhibitory factor in lymphocyte homing in atherosclerosis.
Pathogenic Roles of Macrophage Migration Inhibitory Factor during Dengue Virus Infection.
Review
New
Yeh et al., Tainan City, Taiwan. In Mediators Inflamm, Dec 2014
In this review, we focus on the possible pathogenic effects of a pleiotropic cytokine, macrophage migration inhibitory factor (MIF), on the pathogenesis of DENV infection.
Detection of Human Leukocyte Antigen Biomarkers in Breast Cancer Utilizing Label-free Biosensor Technology.
New
Hawkins et al., Arlington, United States. In J Vis Exp, Dec 2014
Generation of T-cell receptor mimic (TCRm) monoclonal antibodies (mAbs) which recognize breast cancer specific peptide/HLA-A*02:01 complexes such as those derived from macrophage migration inhibitory factor (MIF19-27) and NY-ESO-1157-165 enable detection and destruction of breast cancer cells in the absence of an effective anti-tumor CTL response.
Macrophage Migration Inhibitory Factor Interacting with Th17 Cells May Be Involved in the Pathogenesis of Autoimmune Damage in Hashimoto's Thyroiditis.
New
Liu et al., Binzhou, China. In Mediators Inflamm, Dec 2014
To explore the possible role of MIF and Th17 cells in the thyroid-specific autoimmune damage of Hashimoto's thyroiditis (HT).
[Macrophage migration inhibitory factor and its relationship with obesity and diabetes].
Review
New
Parra-Rojas et al., In Invest Clin, Sep 2014
The macrophage migration inhibitory factor (MIF), is a proinflammatory cytokine involved in autoimmune and inflammatory diseases.
Influence of molecular genetics in Vogt-Koyanagi-Harada disease.
Review
Pang et al., Hong Kong, Hong Kong. In J Ophthalmic Inflamm Infect, 2013
Genes which might be involved in the pathogenesis of VKH disease included genes expressing HLA, complement factor H, interleukins, cytotoxic T-lymphocyte antigen 4 (CTLA-4), killer cell immunoglobulin-like receptors (KIR), programmed cell death 1 (PDCD1), protein tyrosine phosphatase non-receptor 22 (PTPN22), osteopontin, tumor necrosis factor alpha-induced protein 3 (TNFAIP3), macrophage migration inhibitory factor (MIF), and other immune response genes.
The CXCL12/CXCR4 chemokine ligand/receptor axis in cardiovascular disease.
Review
Noels et al., München, Germany. In Front Physiol, 2013
Although the CXCL12/CXCR4 interaction has long been regarded as a monogamous relation, the identification of the pro-inflammatory chemokine macrophage migration inhibitory factor (MIF) as an important second ligand for CXCR4, and of CXCR7 as an alternative receptor for CXCL12, has undermined this interpretation and has considerably complicated the understanding of CXCL12/CXCR4 signaling and associated biological functions.
Cytokine patterns in patients with cancer: a systematic review.
Review
Impact
Lippitz, Stockholm, Sweden. In Lancet Oncol, 2013
In this Review of published clinical studies of patients with cancer, expression and interplay of the following cytokines are examined: interleukin 2, interleukin 6, interleukin 8, interleukin 10, interleukin 12, interleukin 18, tumour necrosis factor α (TNFα), transforming growth factor β (TGFβ), interferon-γ, HLA-DR, macrophage migration inhibitory factor (MIF), and C-X-C motif chemokine receptor 4 (CXCR4).
A novel allosteric inhibitor of macrophage migration inhibitory factor (MIF).
GeneRIF
Anthony et al., New Haven, United States. In J Biol Chem, 2012
p425 blocked the interaction of MIF with its receptor, CD74, and interfered with the pro-inflammatory activities of the cytokine.
Macrophage migration inhibitory factor covalently complexed with phenethyl isothiocyanate.
GeneRIF
Wilbanks et al., Dunedin, New Zealand. In Acta Crystallogr Sect F Struct Biol Cryst Commun, 2012
structure of the modified MIF obtained from X-ray diffraction data to 1.64 A resolution is presented
Macrophage migration inhibitory factor is involved in a positive feedback loop increasing aromatase expression in endometriosis.
GeneRIF
Akoum et al., Québec, Canada. In Am J Pathol, 2012
The present study revealed the existence of a local positive feedback loop by which estrogen acts directly on ectopic endometrial cells to upregulate the expression of MIF, which, in turn, displays the capability of inducing the expression of aromatase.
Macrophage migration inhibitory factor antagonist blocks the development of endometriosis in vivo.
GeneRIF
Akoum et al., Québec, Canada. In Plos One, 2011
Specific inhibition of MIF alters endometriotic tissue growth and progression in vivo and may represent a promising potential therapeutic avenue for endometriosis.
Macrophage migration inhibitory factor is enhanced in acute coronary syndromes and is associated with the inflammatory response.
GeneRIF
Geisler et al., Tübingen, Germany. In Plos One, 2011
Study demonstrated enhanced expression of macrophage migration inhibitory factor in acute coronary syndromes.
Dual nature of the adaptive immune system in lampreys.
Impact
Cooper et al., Atlanta, United States. In Nature, 2009
Conversely, VLRA lymphocytes respond preferentially to a classical T-cell mitogen and upregulate the expression of the pro-inflammatory cytokine genes interleukin-17 (IL-17) and macrophage migration inhibitory factor (MIF).
Glucocorticoid resistance in inflammatory diseases.
Review
Impact
Adcock et al., London, United Kingdom. In Lancet, 2009
Several molecular mechanisms of glucocorticoid resistance have now been identified, including activation of mitogen-activated protein (MAP) kinase pathways by certain cytokines, excessive activation of the transcription factor activator protein 1, reduced histone deacetylase-2 (HDAC2) expression, raised macrophage migration inhibitory factor, and increased P-glycoprotein-mediated drug efflux.
Macrophage migration inhibitory factor stimulates AMP-activated protein kinase in the ischaemic heart.
Impact
GeneRIF
Young et al., New Haven, United States. In Nature, 2008
macrophage migration inhibitory factor (MIF), an upstream regulator of inflammation, is released in the ischaemic heart, where it stimulates AMPK activation through CD74, promotes glucose uptake and protects the heart during ischaemia-reperfusion injury
MIF is a noncognate ligand of CXC chemokine receptors in inflammatory and atherogenic cell recruitment.
Impact
GeneRIF
Weber et al., Aachen, Germany. In Nat Med, 2007
By activating CXCR2 and CXCR4, MIF displays chemokine-like functions and acts as a major regulator of inflammatory cell recruitment and atherogenesis.
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