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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 29 May 2015.

Macrophage migration inhibitory factor

macrophage migration inhibitory factor, GIF
This gene encodes a lymphokine involved in cell-mediated immunity, immunoregulation, and inflammation. It plays a role in the regulation of macrophage function in host defense through the suppression of anti-inflammatory effects of glucocorticoids. This lymphokine and the JAB1 protein form a complex in the cytosol near the peripheral plasma membrane, which may indicate an additional role in integrin signaling pathways. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: HAD, CAN, Interleukin-6, V1a, ACID
Papers using macrophage migration inhibitory factor antibodies
Direct association of thioredoxin-1 (TRX) with macrophage migration inhibitory factor (MIF): regulatory role of TRX on MIF internalization and signaling
Supplier
Hofer Stefan et al., In Mediators of Inflammation, 2008
... R&D Systems, Minneapolis, MN, USA), Human Thioredoxin-1 (Human TRX1, LabFrontier Co., Ltd, Seoul, Korea), and Macrophage Migration Inhibitory Factor (Human MIF, RayBiotech, Inc., Norcross, GA, USA) ...
Papers on macrophage migration inhibitory factor
Serum levels, tissue expression and cellular secretion of macrophage migration inhibitory factor (MIF) in limited and diffuse systemic sclerosis.
New
Giordano et al., Siena, Italy. In Clin Exp Rheumatol, 25 Jun 2015
OBJECTIVES: To investigate serum levels, tissue/cellular expression of macrophage migration inhibitory factor (MIF) in patients with limited (lSSc) and diffuse (dSSc) systemic sclerosis.
Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver.
New
Impact
Lyden et al., New York City, United States. In Nat Cell Biol, 18 Jun 2015
We found that macrophage migration inhibitory factor (MIF) was highly expressed in PDAC-derived exosomes, and its blockade prevented liver pre-metastatic niche formation and metastasis.
Association of Macrophage Migration Inhibitory Factor Polymorphisms with Gestational Diabetes Mellitus in Han Chinese Women.
New
Li et al., Qingdao, China. In Gynecol Obstet Invest, 13 Jun 2015
OBJECTIVE: The purpose of the study was to investigate the association between macrophage migration inhibitory factor (MIF) gene polymorphisms and gestational diabetes mellitus (GDM) in Han Chinese women.
Macrophage migration inhibitory factor promotes cyst growth in polycystic kidney disease.
New
Li et al., In J Clin Invest, 11 Jun 2015
Here, we identified macrophage migration inhibitory factor (MIF) as an important regulator of cyst growth in ADPKD.
A multi-targeted approach to suppress tumor-promoting inflammation.
Review
New
Yang et al., San Diego, United States. In Semin Cancer Biol, 04 Jun 2015
Specifically, macrophage migration inhibitory factor, cyclooxygenase-2, transcription factor nuclear factor-κB, tumor necrosis factor alpha, inducible nitric oxide synthase, protein kinase B, and CXC chemokines are reviewed as important antiinflammatory targets while curcumin, resveratrol, epigallocatechin gallate, genistein, lycopene, and anthocyanins are reviewed as low-cost, low toxicity means by which these targets might all be reached simultaneously.
Increased circulating macrophage migration inhibitory factor levels are associated with coronary artery disease.
New
Bozkaya et al., İzmir, Turkey. In Clinics (sao Paulo), Mar 2015
BACKGROUND: To evaluate the macrophage migration inhibitory factor and E-selectin levels in patients with acute coronary syndrome.
Lymphocyte migration into atherosclerotic plaque.
Review
New
Ley et al., Los Angeles, United States. In Arterioscler Thromb Vasc Biol, Jan 2015
We review evidence for involvement of the chemokines CCL5, CCL19, CCL21, CXCL10, and CXCL16 and macrophage migration inhibitory factor in lymphocyte homing in atherosclerosis.
The macrophage migration inhibitory factor protein superfamily in obesity and wound repair.
Review
New
Bucala et al., New Haven, United States. In Exp Mol Med, Dec 2014
The macrophage migration inhibitory factor (MIF) superfamily consists of MIF and the recently identified homolog D-dopachrome tautomerase (D-DT or MIF-2).
Pathogenic roles of macrophage migration inhibitory factor during dengue virus infection.
Review
New
Yeh et al., Tainan City, Taiwan. In Mediators Inflamm, Dec 2014
In this review, we focus on the possible pathogenic effects of a pleiotropic cytokine, macrophage migration inhibitory factor (MIF), on the pathogenesis of DENV infection.
Macrophage Migration Inhibitory Factor Mediates PAR-Induced Bladder Pain.
New
Vera et al., Lexington, United States. In Plos One, Dec 2014
INTRODUCTION: Macrophage migration inhibitory factor (MIF), a pro-inflammatory cytokine, is constitutively expressed in urothelial cells that also express protease-activated receptors (PAR).
[Macrophage migration inhibitory factor and its relationship with obesity and diabetes].
Review
New
Parra-Rojas et al., In Invest Clin, Sep 2014
The macrophage migration inhibitory factor (MIF), is a proinflammatory cytokine involved in autoimmune and inflammatory diseases.
Cytokine patterns in patients with cancer: a systematic review.
Review
Impact
Lippitz, Stockholm, Sweden. In Lancet Oncol, 2013
In this Review of published clinical studies of patients with cancer, expression and interplay of the following cytokines are examined: interleukin 2, interleukin 6, interleukin 8, interleukin 10, interleukin 12, interleukin 18, tumour necrosis factor α (TNFα), transforming growth factor β (TGFβ), interferon-γ, HLA-DR, macrophage migration inhibitory factor (MIF), and C-X-C motif chemokine receptor 4 (CXCR4).
A novel allosteric inhibitor of macrophage migration inhibitory factor (MIF).
GeneRIF
Anthony et al., New Haven, United States. In J Biol Chem, 2012
p425 blocked the interaction of MIF with its receptor, CD74, and interfered with the pro-inflammatory activities of the cytokine.
Macrophage migration inhibitory factor covalently complexed with phenethyl isothiocyanate.
GeneRIF
Wilbanks et al., Dunedin, New Zealand. In Acta Crystallogr Sect F Struct Biol Cryst Commun, 2012
structure of the modified MIF obtained from X-ray diffraction data to 1.64 A resolution is presented
Macrophage migration inhibitory factor is involved in a positive feedback loop increasing aromatase expression in endometriosis.
GeneRIF
Akoum et al., Québec, Canada. In Am J Pathol, 2012
The present study revealed the existence of a local positive feedback loop by which estrogen acts directly on ectopic endometrial cells to upregulate the expression of MIF, which, in turn, displays the capability of inducing the expression of aromatase.
Macrophage migration inhibitory factor antagonist blocks the development of endometriosis in vivo.
GeneRIF
Akoum et al., Québec, Canada. In Plos One, 2011
Specific inhibition of MIF alters endometriotic tissue growth and progression in vivo and may represent a promising potential therapeutic avenue for endometriosis.
Macrophage migration inhibitory factor is enhanced in acute coronary syndromes and is associated with the inflammatory response.
GeneRIF
Geisler et al., Tübingen, Germany. In Plos One, 2011
Study demonstrated enhanced expression of macrophage migration inhibitory factor in acute coronary syndromes.
Dual nature of the adaptive immune system in lampreys.
Impact
Cooper et al., Atlanta, United States. In Nature, 2009
Conversely, VLRA lymphocytes respond preferentially to a classical T-cell mitogen and upregulate the expression of the pro-inflammatory cytokine genes interleukin-17 (IL-17) and macrophage migration inhibitory factor (MIF).
Glucocorticoid resistance in inflammatory diseases.
Review
Impact
Adcock et al., London, United Kingdom. In Lancet, 2009
Several molecular mechanisms of glucocorticoid resistance have now been identified, including activation of mitogen-activated protein (MAP) kinase pathways by certain cytokines, excessive activation of the transcription factor activator protein 1, reduced histone deacetylase-2 (HDAC2) expression, raised macrophage migration inhibitory factor, and increased P-glycoprotein-mediated drug efflux.
Macrophage migration inhibitory factor stimulates AMP-activated protein kinase in the ischaemic heart.
Impact
GeneRIF
Young et al., New Haven, United States. In Nature, 2008
macrophage migration inhibitory factor (MIF), an upstream regulator of inflammation, is released in the ischaemic heart, where it stimulates AMPK activation through CD74, promotes glucose uptake and protects the heart during ischaemia-reperfusion injury
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