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Macrophage migration inhibitory factor

macrophage migration inhibitory factor, GIF
This gene encodes a lymphokine involved in cell-mediated immunity, immunoregulation, and inflammation. It plays a role in the regulation of macrophage function in host defense through the suppression of anti-inflammatory effects of glucocorticoids. This lymphokine and the JAB1 protein form a complex in the cytosol near the peripheral plasma membrane, which may indicate an additional role in integrin signaling pathways. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, HAD, Interleukin-6, V1a, ACID
Papers using macrophage migration inhibitory factor antibodies
Direct association of thioredoxin-1 (TRX) with macrophage migration inhibitory factor (MIF): regulatory role of TRX on MIF internalization and signaling
Supplier
Hofer Stefan et al., In Mediators of Inflammation, 2008
... R&D Systems, Minneapolis, MN, USA), Human Thioredoxin-1 (Human TRX1, LabFrontier Co., Ltd, Seoul, Korea), and Macrophage Migration Inhibitory Factor (Human MIF, RayBiotech, Inc., Norcross, GA, USA) ...
Papers on macrophage migration inhibitory factor
Trichomonas vaginalis origins, molecular pathobiology and clinical considerations.
New
Sherrard et al., Oxford, United Kingdom. In Curr Opin Infect Dis, 06 Jan 2015
T. vaginalis was shown to secrete exosomes and a macrophage migration inhibitory factor-like protein that both influence host-parasite interactions.
Impact of counterbalance between macrophage migration inhibitory factor and its inhibitor Gremlin-1 in patients with coronary artery disease.
New
Geisler et al., Tübingen, Germany. In Atherosclerosis, 31 Dec 2014
Macrophage migration inhibitory factor (MIF) is involved in atherosclerotic plaque progression and instability leading to intracoronary thrombosis.
Elevated circulating levels of the pro-inflammatory cytokine macrophage migration inhibitory factor in acute spinal cord injury patients.
New
Bloom et al., United States. In Arch Phys Med Rehabil, 15 Dec 2014
OBJECTIVE: To test the hypothesis that MIF is elevated in the circulation of acute SCI as compared to uninjured subjects.
Overexpression of GYS1, MIF, and MYC Is Associated With Adverse Outcome and Poor Response to Azacitidine in Myelodysplastic Syndromes and Acute Myeloid Leukemia.
New
Pérez-Simón et al., Sevilla, Spain. In Clin Lymphoma Myeloma Leuk, 23 Nov 2014
RESULTS: Overexpression of glycogen synthase 1 and macrophage migration inhibitory factor genes had an adverse outcome in multivariate analysis (P = .003
Genes that encodes NAGT, MIF1 and MIF2 are not virulence factors for kala-azar caused by Leishmania infantum.
New
Costa et al., Teresina, Brazil. In Rev Soc Bras Med Trop, Oct 2014
Among the parasite molecules that might influence the disease severity are the macrophage migration inhibitory factor-like proteins (MIF1 and MIF2) and N-acetylglucosamine-1-phosphotransferase (NAGT), which act in the first step of protein N-glycosylation.
Role of MIF in myocardial ischaemia and infarction: insight from recent clinical and experimental findings.
Review
New
Du et al., In Clin Sci (lond), Aug 2014
First discovered in 1966 as an inflammatory cytokine, MIF (macrophage migration inhibitory factor) has been extensively studied for its pivotal role in a variety of inflammatory diseases, including rheumatoid arthritis and atherosclerosis.
Glucocorticoids and macrophage migration inhibitory factor (MIF) are neuroendocrine modulators of inflammation and neuropathic pain after spinal cord injury.
Review
New
Popovich et al., Columbus, United States. In Semin Immunol, May 2014
The relatively recent discovery that macrophage migration inhibitory factor (MIF) is produced throughout the body and can override the anti-inflammatory effects of GCs may provide unique insight to the importance of endogenous and exogenous GCs after SCI.
The CXCL12/CXCR4 chemokine ligand/receptor axis in cardiovascular disease.
Review
New
Noels et al., München, Germany. In Front Physiol, Dec 2013
Although the CXCL12/CXCR4 interaction has long been regarded as a monogamous relation, the identification of the pro-inflammatory chemokine macrophage migration inhibitory factor (MIF) as an important second ligand for CXCR4, and of CXCR7 as an alternative receptor for CXCL12, has undermined this interpretation and has considerably complicated the understanding of CXCL12/CXCR4 signaling and associated biological functions.
Influence of molecular genetics in Vogt-Koyanagi-Harada disease.
Review
New
Pang et al., Hong Kong, Hong Kong. In J Ophthalmic Inflamm Infect, Dec 2013
Genes which might be involved in the pathogenesis of VKH disease included genes expressing HLA, complement factor H, interleukins, cytotoxic T-lymphocyte antigen 4 (CTLA-4), killer cell immunoglobulin-like receptors (KIR), programmed cell death 1 (PDCD1), protein tyrosine phosphatase non-receptor 22 (PTPN22), osteopontin, tumor necrosis factor alpha-induced protein 3 (TNFAIP3), macrophage migration inhibitory factor (MIF), and other immune response genes.
Cytokine patterns in patients with cancer: a systematic review.
Review
New
Impact
Lippitz, Stockholm, Sweden. In Lancet Oncol, May 2013
In this Review of published clinical studies of patients with cancer, expression and interplay of the following cytokines are examined: interleukin 2, interleukin 6, interleukin 8, interleukin 10, interleukin 12, interleukin 18, tumour necrosis factor α (TNFα), transforming growth factor β (TGFβ), interferon-γ, HLA-DR, macrophage migration inhibitory factor (MIF), and C-X-C motif chemokine receptor 4 (CXCR4).
A novel allosteric inhibitor of macrophage migration inhibitory factor (MIF).
GeneRIF
Anthony et al., New Haven, United States. In J Biol Chem, 2012
p425 blocked the interaction of MIF with its receptor, CD74, and interfered with the pro-inflammatory activities of the cytokine.
Macrophage migration inhibitory factor covalently complexed with phenethyl isothiocyanate.
GeneRIF
Wilbanks et al., Dunedin, New Zealand. In Acta Crystallogr Sect F Struct Biol Cryst Commun, 2012
structure of the modified MIF obtained from X-ray diffraction data to 1.64 A resolution is presented
Macrophage migration inhibitory factor is involved in a positive feedback loop increasing aromatase expression in endometriosis.
GeneRIF
Akoum et al., Québec, Canada. In Am J Pathol, 2012
The present study revealed the existence of a local positive feedback loop by which estrogen acts directly on ectopic endometrial cells to upregulate the expression of MIF, which, in turn, displays the capability of inducing the expression of aromatase.
Overview of Macrophage Migration Inhibitory Factor (MIF) as a Potential Biomarker Relevant to Adiposity.
Review
Sakaue et al., Ebetsu, Japan. In J Tradit Complement Med, 2012
The cytokine "macrophage migration inhibitory factor (MIF)" is generally recognized as a proinflammatory cytokine, and MIF is involved in broad range of acute and chronic inflammatory states.
Macrophage migration inhibitory factor antagonist blocks the development of endometriosis in vivo.
GeneRIF
Akoum et al., Québec, Canada. In Plos One, 2011
Specific inhibition of MIF alters endometriotic tissue growth and progression in vivo and may represent a promising potential therapeutic avenue for endometriosis.
Macrophage migration inhibitory factor is enhanced in acute coronary syndromes and is associated with the inflammatory response.
GeneRIF
Geisler et al., Tübingen, Germany. In Plos One, 2011
Study demonstrated enhanced expression of macrophage migration inhibitory factor in acute coronary syndromes.
Dual nature of the adaptive immune system in lampreys.
Impact
Cooper et al., Atlanta, United States. In Nature, 2009
Conversely, VLRA lymphocytes respond preferentially to a classical T-cell mitogen and upregulate the expression of the pro-inflammatory cytokine genes interleukin-17 (IL-17) and macrophage migration inhibitory factor (MIF).
Glucocorticoid resistance in inflammatory diseases.
Review
Impact
Adcock et al., London, United Kingdom. In Lancet, 2009
Several molecular mechanisms of glucocorticoid resistance have now been identified, including activation of mitogen-activated protein (MAP) kinase pathways by certain cytokines, excessive activation of the transcription factor activator protein 1, reduced histone deacetylase-2 (HDAC2) expression, raised macrophage migration inhibitory factor, and increased P-glycoprotein-mediated drug efflux.
Macrophage migration inhibitory factor stimulates AMP-activated protein kinase in the ischaemic heart.
Impact
GeneRIF
Young et al., New Haven, United States. In Nature, 2008
macrophage migration inhibitory factor (MIF), an upstream regulator of inflammation, is released in the ischaemic heart, where it stimulates AMPK activation through CD74, promotes glucose uptake and protects the heart during ischaemia-reperfusion injury
MIF is a noncognate ligand of CXC chemokine receptors in inflammatory and atherogenic cell recruitment.
Impact
GeneRIF
Weber et al., Aachen, Germany. In Nat Med, 2007
By activating CXCR2 and CXCR4, MIF displays chemokine-like functions and acts as a major regulator of inflammatory cell recruitment and atherogenesis.
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