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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Mannose receptor, C type 1

macrophage mannose receptor, CD206, MRCI
The recognition of complex carbohydrate structures on glycoproteins is an important part of several biological processes, including cell-cell recognition, serum glycoprotein turnover, and neutralization of pathogens. The protein encoded by this gene is a type I membrane receptor that mediates the endocytosis of glycoproteins by macrophages. The protein has been shown to bind high-mannose structures on the surface of potentially pathogenic viruses, bacteria, and fungi so that they can be neutralized by phagocytic engulfment.[provided by RefSeq, Apr 2011] (from NCBI)
Top mentioned proteins: Hoxa5, CAN, IL-10, HAD, V1a
Papers using macrophage mannose receptor antibodies
Mechanisms of deoxynivalenol-induced gene expression and apoptosis
Supplier
Guzylack-Piriou Laurence et al., In Veterinary Research, 2007
was commercialized by dendritics (Lyon, France) ...
Tumor-associated macrophages: the double-edged sword in cancer progression
Supplier
Xu Haiyan et al., In Theranostics, 2004
... The cells suspension were collected and were incubated with rabbit anti-mouse monoclonal antibodies (anti-CD68 and anti-CD206; Biolegend Co.) or isotype-matched control ...
Papers on macrophage mannose receptor
Targeted scVEGF/(177)Lu radiopharmaceutical inhibits growth of metastases and can be effectively combined with chemotherapy.
New
Backer et al., Worcester, United States. In Ejnmmi Res, 31 Dec 2016
scVEGF/(177)Lu treatment decreased immunostaining for VEGFR-1, VEGFR-2, and pro-tumorigenic M2-type macrophage marker CD206.
IL-4 administration exerts preventive effects via suppression of underlying inflammation and TNF-α-induced apoptosis in steroid-induced osteonecrosis.
New
Ye et al., Wuhan, China. In Osteoporos Int, Feb 2016
The infiltration of M1/M2 macrophages was examined by the expression of specific makers of F4/80, CD11c, and CD206 protein.
Macrophage infiltration and alternative activation during wound healing promote MEK1-induced skin carcinogenesis.
New
Watt et al., London, United Kingdom. In Cancer Res, Feb 2016
Throughout wound healing and after wound closure, InvEE macrophages demonstrated sustained upregulation of several markers implicated in alternative macrophage activation including arginase-1 (ARG1) and mannose receptor (CD206).
Allergy-Protective Arabinogalactan Modulates Human Dendritic Cells via C-Type Lectins and Inhibition of NF-κB.
New
Bufe et al., Bochum, Germany. In J Immunol, Feb 2016
In the search for a molecular mechanism, we found that AG binds to the immune modulatory receptors DC-specific ICAM-3 -: grabbing non integrin (DC-SIGN) and macrophage mannose receptor 1 (MMR-1).
CD26 costimulatory blockade improves lung allograft rejection and is associated with enhanced interleukin-10 expression.
New
Jungraithmayr et al., Zürich, Switzerland. In J Heart Lung Transplant, Dec 2015
IL-10/CD206 double-staining (alternative macrophages) revealed more positive cells in CD26-I and CD26KO at Day 1 and 5 (p < 0.01).
Arthritic and non-arthritic synovial fluids modulate IL10 and IL1RA gene expression in differentially activated primary human monocytes.
Review
New
Bastiaansen-Jenniskens et al., Milano, Italy. In Osteoarthritis Cartilage, Nov 2015
The transcriptional expression of IL6, IL1B, TNFA, IL10, CCL18, CD206, and IL1RA was analyzed.
Antigen presenting cell-selective drug delivery by glycan-decorated nanocarriers.
Review
New
Kalinke et al., Hannover, Germany. In Eur J Pharm Biopharm, Sep 2015
Examples of CLR expressed by APCs include DEC-205 (CD205) expressed by myeloid dendritic cells (DC) and monocytes, the mannose receptor C type 1 (MR, CD206) expressed by DC, monocytes and macrophages, DC-SIGN (CD209) expressed by DC, and several others.
Lipoxin A4 Attenuates Obesity-Induced Adipose Inflammation and Associated Liver and Kidney Disease.
New
Impact
Godson et al., San Diego, United States. In Cell Metab, Aug 2015
LXA4 decreased obesity-induced adipose inflammation, attenuating TNF-α and CD11c(+) M1-macrophages (MΦs), while restoring CD206(+) M2-MΦs and increasing Annexin-A1.
Changes in transcriptome of macrophages in atherosclerosis.
Review
New
Orekhov et al., Moscow, Russia. In J Cell Mol Med, Jun 2015
Compared to M0 macrophages, M4 cells have a unique transcriptome, with expression of surface markers such as S100A8, mannose receptor CD206 and matrix metalloproteinase 7. M4 macrophages did not express CD163, a scavenger receptor for haemoglobin/haptoglobin complex.
RBP4 activates antigen-presenting cells, leading to adipose tissue inflammation and systemic insulin resistance.
Impact
Kahn et al., Boston, United States. In Cell Metab, 2014
In RBP4-Ox, AT CD206(+) macrophages express proinflammatory markers and activate CD4 T cells while maintaining alternatively activated macrophage markers.
Targeting the C-type lectins-mediated host-pathogen interactions with dextran.
Review
Khan et al., Novosibirsk, Russia. In J Pharm Pharm Sci, 2013
Dextran-binding receptors in humans include the DC-SIGN (dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin) family receptors: DC-SIGN (CD209) and L-SIGN (the liver and lymphatic endothelium homologue of DC-SIGN), the mannose receptor (CD206), and langerin.
The role of iron metabolism as a mediator of macrophage inflammation and lipid handling in atherosclerosis.
Review
Finn et al., Atlanta, United States. In Front Pharmacol, 2013
Hb associated macrophages, M(Hb), are distinct from traditional macrophage foam cells because they do not contain large amounts of lipid or inflammatory cytokines, are characterized by high levels of expression of mannose receptor (CD206) and CD163 in addition to producing anti-inflammatory cytokines such as IL-10.
Low macrophage accumulation in skeletal muscle of obese type 2 diabetics and elderly subjects.
GeneRIF
Ravussin et al., Baton Rouge, United States. In Obesity (silver Spring), 2012
elderly subjects had twofold higher CD68 and CD206 gene expression (both P < 0.002) than young participants. In both studies, CD68(+) muscle macrophages were not associated with BMI
Genetic variants of the MRC1 gene and the IFNG gene are associated with leprosy in Han Chinese from Southwest China.
GeneRIF
Yao et al., Kunming, China. In Hum Genet, 2012
results failed to confirm the reported association between MRC1 variant rs1926736 and IFNG variant rs2430561 and leprosy in Han Chinese; however variants rs692527 and rs34856358 of the MRC1 gene were associated with paucibacillary leprosy and rs3138557 of the IFNG gene was significantly associated with multibacillary leprosy
The macrophage mannose receptor promotes uptake of ADAMTS13 by dendritic cells.
GeneRIF
Voorberg et al., Amsterdam, Netherlands. In Blood, 2012
Sugar moieties on ADAMTS13 interact with MR, thereby promoting its endocytosis by antigen presenting cells.
Polymorphic allele of human MRC1 confer protection against tuberculosis in a Chinese population.
GeneRIF
Li et al., Hangzhou, China. In Int J Biol Sci, 2011
The frequency of MRC1 allele G1186A (rs34039386)in a Chinese population was higher in the pulmonary tuberculosis group than controls. No association was found for G1195A, T1212C, C1221G, C1303T or C1323T.
HIV gp120 binds to mannose receptor on vaginal epithelial cells and induces production of matrix metalloproteinases.
GeneRIF
Bandivdekar et al., Mumbai, India. In Plos One, 2010
hMR expressed by vaginal epithelial cells has high affinity for HIV gp120 and this binding induces production of matrix metalloproteinases.
Memory T(H)2 cells induce alternatively activated macrophages to mediate protection against nematode parasites.
Impact
Gause et al., Newark, United States. In Nat Med, 2006
Examination of the intestinal epithelial submucosa of mice after primary and secondary infections by a natural gastrointestinal parasite revealed a distinct immune-cell infiltrate after challenge, featuring interleukin-4-expressing memory CD4(+) T cells that induced IL-4 receptor(hi) (IL-4R(hi)) CD206(+) alternatively activated macrophages.
The mannose receptor delivers lipoglycan antigens to endosomes for presentation to T cells by CD1b molecules.
Impact
Kronenberg et al., Los Angeles, United States. In Immunity, 1997
The macrophage mannose receptor (MR) was responsible for uptake of LAM.
The receptor DEC-205 expressed by dendritic cells and thymic epithelial cells is involved in antigen processing.
Impact
Nussenzweig et al., New York City, United States. In Nature, 1995
We show here that their antigen-presentation function is associated with the high-level expression of DEC-205, an integral membrane protein homologous to the macrophage mannose receptor and related receptors which are able to bind carbohydrates and mediate endocytosis.
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