Plakins, a versatile family of cytolinkers: roles in skin integrity and in human diseases.
Bern, Switzerland. In J Invest Dermatol, 2014
Here we review the characteristics of the mammalian plakin members BPAG1 (bullous pemphigoid antigen 1), desmoplakin, plectin, envoplakin, epiplakin, MACF1 (microtubule-actin cross-linking factor 1), and periplakin, highlighting their role in skin homeostasis and diseases.
Cell migration: GSK3β steers the cytoskeleton's tip.
Stanford, United States. In Cell, 2011
(2011) demonstrate that the glycogen synthase kinase 3β (GSK3β) controls microtubule architecture and polarized movement of skin stem cells during wound healing in mammals by regulating the microtubule crosslinking protein ACF7.
Plakins in striated muscle.
Greater Sudbury, Canada. In Muscle Nerve, 2010
Among these proteins are crosslinkers belonging to the plakin family, namely plectin, microtubule-actin crosslinking factor (ACF7/MACF1), bullous pemphigoid antigen 1 (Bpag1/dystonin), and desmoplakin.
Spectraplakins: the cytoskeleton's Swiss army knife.
Cambridge, United Kingdom. In Cell, 2008
In this issue, Wu et al. (2008) demonstrate a new actin-dependent ATPase activity for the spectraplakin ACF7 that allows it to guide microtubule ends along actin stress fibers to focal adhesions, promoting disassembly of adhesion contacts and hence cell movement.
Plakins in development and disease.
Amsterdam, Netherlands. In Exp Cell Res, 2007
Microtubule actin cross-linking factor (MACF): a hybrid of dystonin and dystrophin that can interact with the actin and microtubule cytoskeletons.
Pathogenesis of parvovirus B19 infection: host gene variability, and possible means and effects of virus persistence.
London, United Kingdom. In J Vet Med B Infect Dis Vet Public Health, 2005
Six genes were found to be differentially expressed with roles in the cytoskeleton (SKIP, MACF1, SPAG7, FLOT1), integrin signalling (FLOT1, RASSF5), HLA class III (c6orf48), and tumour suppression (RASSF5).
ACF7: an essential integrator of microtubule dynamics.
New York City, United States. In Cell, 2003
In ACF7's absence, microtubules still bind EB1 and CLIP170, but they no longer grow along polarized actin bundles, nor do they pause and tether to actin-rich cortical sites.