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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Methyltransferase like 3

m6A, MT-A70
This gene encodes the 70 kDa subunit of MT-A which is part of N6-adenosine-methyltransferase. This enzyme is involved in the posttranscriptional methylation of internal adenosine residues in eukaryotic mRNAs, forming N6-methyladenosine. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, CD45, ACID, fibrillin-1, FTO
Papers using m6A antibodies
Proteolipid protein (PLP) of CNS myelin: positions of free, disulfide-bonded, and fatty acid thioester-linked cysteine residues and implications for the membrane topology of PLP.
Marcus Adam I., In PLoS ONE, 1991
... To create a GFP-fusion construct, the M6a coding sequence was excised and sub-cloned into the pEGFP-C1 vector (Clontech) such that the N-terminal ...
Papers on m6A
Cracking the epitranscriptome.
Schwartz, Israel. In Rna, Feb 2016
This review focuses on recent advances, knowledge gaps, and challenges pertaining to N6-methyladenosine (m6A), an abundant modification of mRNA for which substantial progress has been made in recent years.
LncRNAs: key players and novel insights into cervical cancer.
Li et al., Changsha, China. In Tumour Biol, Jan 2016
In this review, we summarized the origin and overview function of lncRNAs; highlighted the roles of lncRNAs in cervical cancer in terms of prognosis and tumor progression, invasion and metastasis, apoptosis, and radio-resistance; and outlined the molecular mechanisms of lncRNAs in cervical cancer from the aspects of the interaction of lncRNAs with proteins/mRNAs (especially in HPV protein) and miRNAs, as well as RNA N-methyladenosine (m6A) methylation of lncRNAs.
A Radioactivity-Based Assay for Screening Human m6A-RNA Methyltransferase, METTL3-METTL14 Complex, and Demethylase ALKBH5.
Vedadi et al., Toronto, Canada. In J Biomol Screen, Jan 2016
METTL3 and METTL14 are N(6)-adenosine methyltransferases that work more efficiently in a stable METTL3-METTL14 heterodimer complex (METTL3-14).
A majority of m6A residues are in the last exons, allowing the potential for 3' UTR regulation.
Darnell et al., New York City, United States. In Genes Dev, Nov 2015
Furthermore, when we reduced m6A methylation by knocking down components of the methylase complex and then examined 661 transcripts with proximal m6A peaks in last exons, we identified a set of 111 transcripts with altered (approximately two-thirds increased proximal) APA use.
Structural and Functional Characterization of the Proteins Responsible for N6-Methyladenosine Modification and Recognition.
Qi et al., Wuhan, China. In Curr Protein Pept Sci, Oct 2015
METTL3 complex, the m6A methyltransferases, and two kinds of demethylases including Fat mass and obesity-associated protein (FTO) and alkylation protein AlkB homolog 5 (ALKBH5) are characterized thus far.
Single-nucleotide-resolution mapping of m6A and m6Am throughout the transcriptome.
Jaffrey et al., New York City, United States. In Nat Methods, Aug 2015
N(6)-methyladenosine (m6A) is the most abundant modified base in eukaryotic mRNA and has been linked to diverse effects on mRNA fate.
An Adenine Code for DNA: A Second Life for N6-Methyladenine.
Esteller et al., Barcelona, Spain. In Cell, Jun 2015
New data now find that 6mA may have a gene regulatory function in green alga, worm, and fly, suggesting m6A as a potential "epigenetic" mark.
Stem cells. m6A mRNA methylation facilitates resolution of naïve pluripotency toward differentiation.
Hanna et al., Israel. In Science, Mar 2015
Here, we identify Mettl3, an N(6)-methyladenosine (m(6)A) transferase, as a regulator for terminating murine naïve pluripotency.
miRNA and methylation: a multifaceted liaison.
Chhabra, Chandīgarh, India. In Chembiochem, Feb 2015
Surprisingly, the two most commonly studied methylation states in mRNA (m6A and m5C) are found to be enriched in 3'-UTRs (untranslated regions), the target site for the majority of miRNAs.
Fate by RNA methylation: m6A steers stem cell pluripotency.
He et al., In Genome Biol, 2014
The N 6-methyladenosine (m6A) modification of mRNA has a crucial function in regulating pluripotency in murine stem cells: it facilitates resolution of naïve pluripotency towards differentiation.
Complete genome sequence of Salinicoccus halodurans H3B36, isolated from the Qaidam Basin in China.
Ma et al., Beijing, China. In Stand Genomic Sci, 2014
Further analysis of epigenetic modifications revealed the presence of 11,000 m4C-type modified bases, 7,545 m6A-type modified bases, and 89,064 other modified bases.
Immuno-Northern Blotting: Detection of RNA Modifications by Using Antibodies against Modified Nucleosides.
Abe et al., Sendai, Japan. In Plos One, 2014
We confirmed that INB with the antibodies for 1-methyladenosine (m1A), N6-methyladenosine (m6A), pseudouridine, and 5-methylcytidine (m5C) showed different modifications in a variety of RNAs from various species and organelles.
Insights on virulence from the complete genome of Staphylococcus capitis.
Peleg et al., Melbourne, Australia. In Front Microbiol, 2014
Methylome analysis identified significant adenine methylation across the genome involving two distinct methylation motifs (1972 putative 6-methyladenine (m6A) residues identified).
Genome-wide mapping of methylated adenine residues in pathogenic Escherichia coli using single-molecule real-time sequencing.
Schadt et al., Minneapolis, United States. In Nat Biotechnol, 2012
We used this approach to detect 49,311 putative 6-methyladenine (m6A) residues and 1,407 putative 5-methylcytosine (m5C) residues in the genome of a pathogenic Escherichia coli strain.
Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq.
Rechavi et al., Israel. In Nature, 2012
An extensive repertoire of modifications is known to underlie the versatile coding, structural and catalytic functions of RNA, but it remains largely uncharted territory.
Neuronal glycoprotein M6a induces filopodia formation via association with cholesterol-rich lipid rafts.
Frasch et al., San Martín, Argentina. In J Neurochem, 2011
Association of neuronal M6a with cholesterol-rich lipid rafts is important for M6a glycoprotein's role in filopodia formation and signal propagation.
Induction of axon growth arrest without growth cone collapse through the N-terminal region of four-transmembrane glycoprotein M6a.
Hirata et al., Mishima, Japan. In Dev Neurobiol, 2011
M6a-deficient axons grow actively but are not growth suppressed by antibodies bound to four-transmembrane actin-based glycoprotein M6a concentrated on the edge of the axon growth cone.
Actin-independent behavior and membrane deformation exhibited by the four-transmembrane protein M6a.
Hirata et al., Mishima, Japan. In Plos One, 2010
analysis of actin-independent behavior and membrane deformation exhibited by the four-transmembrane protein M6a
Filopodial protrusions induced by glycoprotein M6a exhibit high motility and aids synapse formation.
Frasch et al., Buenos Aires, Argentina. In Eur J Neurosci, 2010
Data suggest that M6a is a key molecule for dendritic spine formation during development.
Human GPM6A is associated with differentiation and neuronal migration of neurons derived from human embryonic stem cells.
Taniguchi et al., Ōsaka, Japan. In Stem Cells Dev, 2009
Results suggest that expression level of GPM6A is associated with the differentiation and neuronal migration of neurons derived from undifferentiated human embryonic stem cells.
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