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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Pyruvate kinase, muscle

M2-PK, Tumor M2-PK, PKM2, PKM, PK3
This gene encodes a protein involved in glycolysis. The encoded protein is a pyruvate kinase that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate to ADP, generating ATP and pyruvate. This protein has been shown to interact with thyroid hormone and may mediate cellular metabolic effects induced by thyroid hormones. This protein has been found to bind Opa protein, a bacterial outer membrane protein involved in gonococcal adherence to and invasion of human cells, suggesting a role of this protein in bacterial pathogenesis. Several alternatively spliced transcript variants encoding a few distinct isoforms have been reported. [provided by RefSeq, May 2011] (from NCBI)
Top mentioned proteins: Hoxa5, CAN, ACID, HAD, V1a
Papers on M2-PK
SIRT6 deacetylates PKM2 to suppress its nuclear localization and oncogenic functions.
New
Das et al., New Delhi, India. In Proc Natl Acad Sci U S A, Feb 2016
Here we report that SIRT6 binds to and deacetylates nuclear PKM2 (pyruvate kinase M2) at the lysine 433 residue.
PKLR promotes colorectal cancer liver colonization through induction of glutathione synthesis.
New
Tavazoie et al., In J Clin Invest, Feb 2016
PKLR negatively regulated the glycolytic activity of PKM2, the major pyruvate kinase isoenzyme known to regulate cellular glutathione levels.
A transcriptional miRNA-gene network associated with lung adenocarcinoma metastasis based on the TCGA database.
New
He et al., Chongqing, China. In Oncol Rep, Feb 2016
Our data suggested that some of the genes including PKM2, STRAP and FLT3, may participate in the pathology of lung adenocarcinoma metastasis and could be applied as potential markers or therapeutic targets for lung adenocarcinoma.
Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to the development of pulmonary arterial hypertension.
New
Gu et al., Beijing, China. In J Mol Cell Cardiol, Feb 2016
METHODS AND RESULTS: By Western blots, we showed that increased intracellular ROS caused inhibition of the glycolytic pyruvate kinase M2 (PKM2) activity through promoting the phosphorylation of PKM2.
M-Type Pyruvate Kinase Isoforms and Lactate Dehydrogenase A in the Mammalian Retina: Metabolic Implications.
New
Chidlow et al., Adelaide, Australia. In Invest Ophthalmol Vis Sci, Feb 2016
The molecular switch controlling glycolytic flow is thought to be an isoenzyme of pyruvate kinase (PKM2).
Pyruvate kinase: Function, regulation and role in cancer.
Review
New
Vander Heiden et al., Cambridge, United States. In Semin Cell Dev Biol, Jul 2015
The M2 isoform of pyruvate kinase (PKM2) supports anabolic metabolism and is expressed both in cancer and normal tissue.
Molecular Analysis of Inflammatory Bowel Disease: Clinically Useful Tools for Diagnosis, Response Prediction, and Monitoring of Targeted Therapy.
Review
New
Li et al., Baltimore, United States. In Mol Diagn Ther, Jun 2015
Fecal biomarkers, which have recently attracted substantial attention, are also discussed extensively, including the well-characterized calprotectin and lactoferrin, as well as the recently characterized M2-PK, CHI3L1, neopterin, MMP-9, and HMGB1.
SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance.
New
Impact
Sabatini et al., Cambridge, United States. In Nature, May 2015
We find that SHMT2 activity limits that of pyruvate kinase (PKM2) and reduces oxygen consumption, eliciting a metabolic state that confers a profound survival advantage to cells in poorly vascularized tumour regions.
[Fecal Biomarker for Colorectal Cancer Diagnosis].
Review
New
Matsumura et al., In Rinsho Byori, Mar 2015
Fecal calprotectin, which indicates intestinal bleeding or inflammation of the colon mucosa, and fecal tumor M2-PK, which is produced by cancer cells, have been extensively investigated as fecal protein biomarkers.
Pyruvate kinase M2 regulates Hif-1α activity and IL-1β induction and is a critical determinant of the warburg effect in LPS-activated macrophages.
New
Impact
O'Neill et al., Dublin, Ireland. In Cell Metab, Feb 2015
We here show that LPS induces expression of the key metabolic regulator Pyruvate Kinase M2 (PKM2).
The response of trypanosomes and other eukaryotes to ER stress and the spliced leader RNA silencing (SLS) pathway in Trypanosoma brucei.
Review
Michaeli, Ramat Gan, Israel. In Crit Rev Biochem Mol Biol, 2014
Induction of SLS is mediated by an ER-associated kinase (PK3) that migrates to the nucleus, where it phosphorylates the TATA-binding protein (TRF4), leading shut-off of SL RNA transcription.
A systematic review and meta-analysis of the diagnostic accuracy of pyruvate kinase M2 isoenzymatic assay in diagnosing colorectal cancer.
Review
Faiz et al., London, United Kingdom. In World J Surg Oncol, 2014
Stool-based pyruvate kinase isoenzyme M2 (M2-PK) is one such biomarker under investigation.
Cell-state-specific metabolic dependency in hematopoiesis and leukemogenesis.
Impact
Scadden et al., Boston, United States. In Cell, 2014
We find that a deficiency in the M2 pyruvate kinase isoform (PKM2) reduces the levels of metabolic intermediates important for biosynthesis and impairs progenitor function without perturbing hematopoietic stem cells (HSCs), whereas lactate dehydrogenase A (LDHA) deletion significantly inhibits the function of both HSCs and progenitors during hematopoiesis.
PKM2 isoform-specific deletion reveals a differential requirement for pyruvate kinase in tumor cells.
Impact
Vander Heiden et al., Cambridge, United States. In Cell, 2013
The pyruvate kinase M2 isoform (PKM2) is expressed in cancer and plays a role in regulating anabolic metabolism.
Loss of FBP1 by Snail-mediated repression provides metabolic advantages in basal-like breast cancer.
Impact
Zhou et al., Lexington, United States. In Cancer Cell, 2013
Loss of FBP1 induces glycolysis and results in increased glucose uptake, macromolecule biosynthesis, formation of tetrameric PKM2, and maintenance of ATP production under hypoxia.
Identification of anti-retinal antibodies in patients with age-related macular degeneration.
GeneRIF
Ono et al., Tokyo, Japan. In Exp Mol Pathol, 2012
In patients with age-related macular degeneration, anti-PKM2 IgG serves as a biomarker for diagnosis and prognosis.
PKM2 phosphorylates histone H3 and promotes gene transcription and tumorigenesis.
Impact
GeneRIF
Lu et al., Houston, United States. In Cell, 2012
These findings highlight the role of PKM2 as a protein kinase in its nonmetabolic functions of histone modification, which is essential for its epigenetic regulation of gene expression and tumorigenesis.
Fecal M2-PK in children with Crohn's disease: a preliminary report.
GeneRIF
Leach et al., Christchurch, New Zealand. In Dig Dis Sci, 2012
Fecal M2-PK is increased in children with active Crohn's disease.
Pyruvate kinase M2 promotes the growth of gastric cancer cells via regulation of Bcl-xL expression at transcriptional level.
GeneRIF
Kim et al., Taejŏn, South Korea. In Biochem Biophys Res Commun, 2012
PKM2 may function as an upstream molecule that regulates p65 function and thus enhances the growth of tumor cells.
Pyruvate kinase M2 promotes de novo serine synthesis to sustain mTORC1 activity and cell proliferation.
GeneRIF
Thompson et al., New York City, United States. In Proc Natl Acad Sci U S A, 2012
PKM2-expressing cells can maintain mammalian target of rapamycin complex 1 activity and proliferate in serine-depleted medium, but PKM1-expressing cells cannot.
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