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Eukaryotic translation initiation factor 3, subunit K

M-9, Arg134, eIF3k
The 700-kD eukaryotic translation initiation factor-3 (eIF3) is the largest eIF and contains at least 12 subunits, including EIF2S12. eIF3 plays an essential role in translation by binding directly to the 40S ribosomal subunit and promoting formation of the 40S preinitiation complex (Mayeur et al., 2003 [PubMed 14519125]).[supplied by OMIM, Mar 2008] (from NCBI)
Top mentioned proteins: ACID, CAN, GAPDH, HAD, 110-kDa
Papers on M-9
The validation of housekeeping genes as a reference in quantitative Real Time PCR analysis: application in the milk somatic cells and frozen whole blood of goats infected with caprine arthritis encephalitis virus.
Bagnicka et al., Poland. In Gene, 2014
The stability of expression of β-actin (ACTB), glyceraldehyde-3P-dehydrogenase (GAPDH), cyclophilin A (PPIA), RNA18S1, ubiquilin (UBQLN1) and ribosomal protein large subunit P0 (RPLP0) was determined in milk somatic cells, while ACTB, PPIA, RPLP0, succinate dehydrogenase complex subunit A (SDHA), zeta polypeptide (YWHAZ), battenin (CLN3), eukaryotic translation initiation factor 3K (EIF3K) and TATA box-binding protein (TBP) were measured in frozen whole blood of goats.
The quest for a thermostable sucrose phosphorylase reveals sucrose 6'-phosphate phosphorylase as a novel specificity.
Desmet et al., Gent, Belgium. In Appl Microbiol Biotechnol, 2014
Homology modelling and mutagenesis pointed out particular residues (Arg134 and His344) accounting for the difference in specificity.
Insights into the stereospecificity of the d-specific dehalogenase from Rhizobium sp. RC1 toward d- and l-2-chloropropionate.
Huyop et al., Johor Bahru, Malaysia. In Biotechnol Biotechnol Equip, 2014
For this study, we performed in silico docking and molecular dynamic simulations of complexes formed by this dehalogenase and d- or l-2-chloropropionate. Arg134 of the enzyme plays the key role in the stereospecific binding and Arg16 is in a position that would allow it to activate a water molecule for hydrolytic attack on the d-2-chloropropionate chiral carbon for release of the halide ion to yield l-2-hydroxypropionate.
Selection of reference genes for quantitative real-time PCR normalisation in adipose tissue, muscle, liver and mammary gland from ruminants.
Leroux et al., Clermont-Ferrand, France. In Animal, 2013
In this study, eight commonly used reference genes that belong to different functional classes (CLN3, EIF3K, MRPL39, PPIA, RPLP0, TBP, TOP2B and UXT) were analysed using the geNorm procedure to determine the most stable reference genes in bovine and/or caprine tissues.
Comparative proteomic analysis of colon cancer cell HCT-15 in response to all-trans retinoic acid treatment.
Du et al., Hangzhou, China. In Protein Pept Lett, 2012
Among the identified differentially expressed proteins, there were four scaffold proteins (YWHAE, SFN, YWHAB, and YWHAZ), two ubiquitin modification related proteins (ISG-15 and UBE2N), two translational initiation factors (EIF1AX and EIF3K), two cytoskeleton related proteins (EZRI and CNN3), two proteinmodification related proteins (TXNDC17 and PIMT), and one enzyme related to phospholipid metabolism (PSP).
Human-like eukaryotic translation initiation factor 3 from Neurospora crassa.
Cate et al., Berkeley, United States. In Plos One, 2012
Consistent with this model, subunits eIF3k and eIF3l are incorporated into the eIF3 complex as a pair, and their insertion depends on the presence of subunit eIF3h, a key regulator of vertebrate development.
Crystal structure of a four-layer aggregate of engineered TMV CP implies the importance of terminal residues for oligomer assembly.
Chen et al., Guiyang, China. In Plos One, 2012
The conformations of residues Gln36, Thr59, Asp115 and Arg134 were carefully analyzed in the high radius and low radius regions of N-His-TMV CP(19), which were found to be significantly different from those observed previously for the helical and four-layer aggregate forms.
Technical note: identification of reference genes for gene expression studies in different bovine tissues focusing on different fat depots.
Mielenz et al., Bonn, Germany. In J Dairy Sci, 2012
The 3 most stable REF in individual fat tissues and muscle were EMD (emerin), POLR2A (RNA polymerase II), and LRP10 (lipoprotein receptor-related protein 10); in mammary gland were MARVELD1 (marvel domain containing 1), EMD, and LRP10; and in liver were HPCAL1 (hippocalcin-like 1), LRP10, and EIF3K (Eukaryotic translation initiation factor 3).
Structure prediction, molecular dynamics simulation and docking studies of D-specific dehalogenase from Rhizobium sp. RC1.
Huyop et al., Johor Bahru, Malaysia. In Int J Mol Sci, 2011
Docking analysis revealed that Arg107, Arg134 and Tyr135 interacted with D-2CP, and Glu20 activated the water molecule for hydrolytic dehalogenation.
C. elegans EIF-3.K promotes programmed cell death through CED-3 caspase.
Wu et al., Taipei, Taiwan. In Plos One, 2011
Here we have identified an additional component eif-3.K (eukaryotic translation initiation factor 3 subunit k) that acts upstream of ced-3 to promote programmed cell death.
Methodology for measuring conformation of solvent-disrupted protein subunits using T-WAVE ion mobility MS: an investigation into eukaryotic initiation factors.
Hershey et al., Davis, United States. In J Am Soc Mass Spectrom, 2009
The methodology developed in the research presented herein makes use of chaotropic solvents to gently dissociate subunits from an intact macromolecular complex and subsequently allows for the measurement of collision cross section (CCS) for both the recombinant (R-eIF3k) and solvent dissociated form of the subunit (S-eIF3k).
Identification of internal control genes for quantitative polymerase chain reaction in mammary tissue of lactating cows receiving lipid supplements.
Loor et al., College Park, United States. In J Dairy Sci, 2009
Among those COPS7A, CORO1B, DNAJC19, EIF3K, EMD, GOLGA5, MTG1, UXT, MRPL39, GPR175, and MARVELD1 (sample/reference expression ratio = 1 +/- 0.1) were selected for PCR analysis upon verification of goodness of BLAT/BLAST sequence and primer design.
eIF3k regulates apoptosis in epithelial cells by releasing caspase 3 from keratin-containing inclusions.
GeneRIF
Chen et al., Taiwan. In J Cell Sci, 2008
eIF3k, originally identified as the smallest subunit of eukaryotic translation initiation factor 3 (eIF3) complexes, also localizes to keratin intermediate filaments and physically associates with K18 in epithelial cells.
Biochemical and structural characterization of the secreted chorismate mutase (Rv1885c) from Mycobacterium tuberculosis H37Rv: an *AroQ enzyme not regulated by the aromatic amino acids.
Reddy et al., Gaithersburg, United States. In J Bacteriol, 2006
Analysis of the structure shows a novel fold topology for the protein with a topologically rearranged helix containing Arg134.
Identification of structural and catalytic classes of highly conserved amino acid residues in lysine 2,3-aminomutase.
Ruzicka et al., Madison, United States. In Biochemistry, 2006
Mutation of the conserved residues Arg134, Asp293, and Asp330 abolishes all enzymatic activity.
Identification of the p28 subunit of eukaryotic initiation factor 3(eIF3k) as a new interaction partner of cyclin D3.
GeneRIF
Gu et al., Shanghai, China. In Febs Lett, 2004
cyclin D3 specifically interacted with eIF3k through its C-terminal domain; eIF3k distributed both in nucleus and cytoplasm and colocalized with cyclin D3
Crystal structure of human eIF3k, the first structure of eIF3 subunits.
GeneRIF
Gong et al., Beijing, China. In J Biol Chem, 2004
eIF3k has three putative protein-binding surfaces and has potential RNA binding activity
PLAC-24 is a cytoplasmic dynein-binding protein that is recruited to sites of cell-cell contact.
GeneRIF
Holzbaur et al., Philadelphia, United States. In Mol Biol Cell, 2002
identification of a novel 24-kDa protein that binds directly to dynein intermediate chain [PLAC-24]
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