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Lymphatic vessel endothelial hyaluronan receptor 1

LYVE-1, lymphatic vessel endothelial hyaluronan receptor-1
This gene encodes a type I integral membrane glycoprotein. The encoded protein acts as a receptor and binds to both soluble and immobilized hyaluronan. This protein may function in lymphatic hyaluronan transport and have a role in tumor metastasis. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: vascular endothelial growth factor, VEGF-C, PCL, KDR, CD31
Papers using LYVE-1 antibodies
Saturated fatty acids enhance osteoclast survival
Supplier
Park Jung Han Yoon et al., In Breast Cancer Research : BCR, 2009
... were purchased from the suppliers as indicated: antibodies against Ki-67, hypoxia-inducible factor-1 alpha (HIF-1α), and lymphatic vessel endothelial hyaluronan receptor-1 from Abcam (Cambridge, UK); antibodies against ...
Quantitation of angiogenesis and its correlation with vascular endothelial growth factor expression in astrocytic tumors
Supplier
Ylä-Herttuala Seppo et al., In Molecular Therapy. Nucleic Acids, 2003
... for Src (1:50; Cell Signalling Technology), mouse CD34 (1:10; HyCult Biotechnology b.v., Uden, the Netherlands), LYVE-1 (1:1,000; ReliaTech, Braunschweig, Germany), Ki-67 (1:50; Dako, Glostrup, Denmark) and anti-Muscle ...
VEGF receptor signal transduction.
Supplier
Kume Tsutomu, In PLoS ONE, 2000
... Signaling #2479); rabbit anti-phospho-Akt (Ser 473, Cell Signaling #9271S); rabbit anti-Akt (Cell Signaling #9272); rabbit anti-LYVE-1 (abcam ab14917); and rabbit anti-Prox1 ...
Papers on LYVE-1
Zinc effect on human lymphatic malformation cells in vitro.
New
Ma et al., New York City, United States. In Int J Pediatr Otorhinolaryngol, Jan 2016
Immunohistochemical staining (CD31, D2-40, and LYVE-1) and cell morphology of our specimens were consistent with lymphatic malformation while HUVEC control cells were negative.
Anti-inflammatory and lymphangiogenetic effects of low-level laser therapy on lymphedema in an experimental mouse tail model.
New
Jeon et al., Inch'ŏn, South Korea. In Lasers Med Sci, Jan 2016
Macrophage activation and lymphatic vessel regeneration were evaluated through immunohistochemical staining with anti-F4/80 and anti-LYVE-1 antibodies, respectively, at 12 days post-procedure.
Co-expression of vascular and lymphatic endothelial cell markers on early endothelial cells present in aspirated coronary thrombi from patients with ST-elevation myocardial infarction.
New
Labudovic-Borovic et al., Belgrade, Serbia. In Exp Mol Pathol, Jan 2016
Since the coronary thrombi material aspirated from patients with ST-elevation myocardial infarction (STEMI) proved as good angiogenesis model, we investigated the expression of CD34 and CD31 as BECs markers, and D2-40, LYVE-1 and VEGFR3 as LEC markers in this material.
Roles of mPGES-1, an inducible prostaglandin E synthase, in enhancement of LPS-induced lymphangiogenesis in a mouse peritonitis model.
New
Majima et al., Sagamihara, Japan. In Life Sci, Jan 2016
MAIN METHODS: Peritonitis was induced in mice by intraperitoneal injection of LPS (E. coli 0111-B4; 25μg/mouse every 2days), and IL was evaluated by LYVE-1 immunostaining of whole-mount diaphragm tissues.
Isolation and Characterization of a Murine Spontaneous High-Grade Follicular Lymphoma with Restricted In Vivo Spreading - a Model for Lymphatic Metastasis Via the Mesentery.
New
Balogh et al., Pécs, Hungary. In Pathol Oncol Res, Dec 2015
Similarly, the LYVE-1-positive lymphatic capillaries within the mesentery were packed with lymphoma cells.
Lymphatic Markers in the Adult Human Choroid.
New
Reitsamer et al., Salzburg, Austria. In Invest Ophthalmol Vis Sci, Dec 2015
Sections were processed for immunohistochemistry of the lymphatic markers LYVE-1, PDPN, PROX1, FOXC2, VEGFR3, CCL21, and combined with α-smooth muscle-actin and 4',6-diamidino-2-phenylendole (DAPI).
Optical clearing based cellular-level 3D visualization of intact lymph node cortex.
New
Kim et al., Taejŏn, South Korea. In Biomed Opt Express, Nov 2015
With adoptive transfer of GFP expressing B cells and DsRed expressing T cells and fluorescent vascular labeling by anti-CD31 and anti-LYVE-1 antibody conjugates, we successfully visualized major cellular-level structures such as T-cell zone, B-cell follicle and germinal center.
Curative effect of paclitaxel and cisplatin combined chemotherapy on cervical cancer and its relation with tissue micro vascular and lymphatic vessels density.
New
Wang et al., Xinxiang, China. In Pak J Pharm Sci, Sep 2015
The postoperative paraffin tissue had been collected, had performed the LYVE-1 (lymphatic endothelium specific hyaluronan receptor-1) and CD31 immunohistochemical staining.
Lymphatic manifestations of lymphangioleiomyomatosis.
Review
McCormack et al., In Lymphology, 2014
LAM lesions express lymphangiogenic growth factors VEGF-C and VEGF-D; growth factor receptors, VEGFR-2 and VEGFR-3; and markers LYVE-1 and podoplanin, and are laced with chaotic lymphatic channels.
CD147: regulator of hyaluronan signaling in invasiveness and chemoresistance.
Review
Toole et al., Charleston, United States. In Adv Cancer Res, 2013
CD147 both regulates HA synthesis and interacts with the HA receptors, CD44, and LYVE-1.
Role of tumor associated macrophages in tumor angiogenesis and lymphangiogenesis.
Review
Kzhyshkowska et al., Mannheim, Germany. In Front Physiol, 2013
TAM can express LYVE-1, one of the established markers of lymphatic endothelium.
[Lymphatic vascular system, development and lymph formation. Review].
Review
Lacave et al., Paris, France. In Rev Pneumol Clin, 2013
Lymphatic endothelial cells are routinely identified by the expression of podoplanin, LYVE-1 and VEGFR3.
Initial afferent lymphatic vessels controlling outbound leukocyte traffic from skin to lymph nodes.
Review
Melero et al., Pamplona, Spain. In Front Immunol, 2012
Tissue drains fluid and macromolecules through lymphatic vessels (LVs), which are lined by a specialized endothelium that expresses peculiar differentiation proteins, not found in blood vessels (i.e., LYVE-1, Podoplanin, PROX-1, and VEGFR-3).
Smooth muscle-endothelial cell communication activates Reelin signaling and regulates lymphatic vessel formation.
GeneRIF
Makinen et al., London, United Kingdom. In J Cell Biol, 2012
Reelin-deficient mice showed abnormal collecting lymphatic vessels, characterized by a reduced number of SMCs, abnormal expression of lymphatic capillary marker lymphatic vessel endothelial hyaluronan receptor 1 (LYVE-1), and impaired function
CRSBP-1/LYVE-1 ligands stimulate contraction of the CRSBP-1-associated ER network in lymphatic endothelial cells.
GeneRIF
Huang et al., Saint Louis, United States. In Febs Lett, 2012
CRSBP-1-associated fibrillar structures are identical to the ER network as evidenced by the co-localization of CRSBP-1 and BiP in these cells
Discontinuous LYVE-1 expression in corneal limbal lymphatics: dual function as microvalves and immunological hot spots.
GeneRIF
Hafezi-Moghadam et al., Boston, United States. In Faseb J, 2012
report intact CD31(+) corneal lymphatic capillary endothelial cells that do not express LYVE-1. The number of LYVE-1(-) gaps initially increased until 8 wk of age but was significantly reduced in aged mice.
LYVE-1 upregulation and lymphatic invasion correlate with adverse prognostic factors and lymph node metastasis in neuroblastoma.
GeneRIF
May et al., Bristol, United Kingdom. In Virchows Arch, 2012
LYVE-1 may have value as predictor of outcome in neuroblastoma
Relationship between LYVE-1, VEGFR-3 and CD44 gene expressions and lymphatic metastasis in gastric cancer.
GeneRIF
Kansu et al., Ankara, Turkey. In World J Gastroenterol, 2011
LYVE-1, VEGFR-3 and CD44 all play an important role in lymphangiogenesis, invasion and metastasis
Vascular endothelial growth factor-D and its receptor VEGFR-3: two novel independent prognostic markers in gastric adenocarcinoma.
Impact
Höcker et al., Berlin, Germany. In J Clin Oncol, 2006
Blood and lymph vessel densities were assessed after staining with CD31 and LYVE-1-specific antibodies.
Induction of tumor lymphangiogenesis by VEGF-C promotes breast cancer metastasis.
Impact
Detmar et al., United States. In Nat Med, 2001
Using a novel marker for lymphatic endothelium, LYVE-1, we demonstrate here the occurrence of intratumoral lymphangiogenesis within human breast cancers after orthotopic transplantation onto nude mice.
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