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Lysyl oxidase

lysyl oxidase, Protein-Lysine 6-Oxidase, LOX
The protein encoded by this gene is an extracellular copper enzyme that initiates the crosslinking of collagens and elastin. The enzyme catalyzes oxidative deamination of the epsilon-amino group in certain lysine and hydroxylysine residues of collagens and lysine residues of elastin. In addition to crosslinking extracellular matrix proteins, the encoded protein may have a role in tumor suppression. Defects in this gene are a cause of autosomal recessive cutis laxa type I (CL type I). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2010] (from NCBI)
Top mentioned proteins: ACID, LOX-1, CAN, 5-lipoxygenase, V1a
Papers using lysyl oxidase antibodies
Maresins: novel macrophage mediators with potent antiinflammatory and proresolving actions
Supplier
Spite Matthew et al., In The Journal of Experimental Medicine, 2006
... DHA, 12-LOX (porcine), 5-LOX (human), 17-HDHA-d5, and PGE2-d4 were purchased from Cayman Chemical ...
Protein level of apolipoprotein E increased in human hepatocellular carcinoma
Supplier
Gong Zhiyuan et al., In Disease Models & Mechanisms, 2005
... Heat shock-inducible Cre/Lox approaches to induce diverse types of tumors and hyperplasia in transgenic zebrafish ...
Cerebral ischemia in 5-lipoxygenase knockout mice.
Supplier
Langsley Gordon, In PLoS ONE, 2003
... 5-HPETE, and arachidonic acid, the product and substrate of 5-LOX respectively, were from Biomol (Plymouth, PA) ...
Regulation of bone mass in mice by the lipoxygenase gene Alox15
Supplier
Fahmi Hassan et al., In Arthritis Research & Therapy, 2003
... GW9662, 13(S)-HODE, 15(S)-HETE, anti-15-LOX-1 and 15-LOX-2 antibodies were from Cayman Chemical Co ...
The CLUSTAL X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools
Supplier
Toyama Marcos H. et al., In Evidence-based Complementary and Alternative Medicine : eCAM, 2001
... The COX-1, COX-2, LOX 15hrc, and LOX 15syP1 came from Cayman Chemical ...
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Papers on lysyl oxidase
Crystal Structure of Manganese Lipoxygenase of the Rice Blast Fungus Magnaporthe oryzae.
New
Chen et al., Uppsala, Sweden. In J Biol Chem, Feb 2016
UNASSIGNED: Lipoxygenases (LOX) are non-heme metal enzymes, which oxidize polyunsaturated fatty acids to hydroperoxides.
Lysyl Oxidase, a Targetable Secreted Molecule Involved in Cancer Metastasis.
Review
New
Erler et al., Copenhagen, Denmark. In Cancer Res, Feb 2016
Recently, we showed that hypoxic induction of the extracellular matrix modifying enzyme lysyl oxidase (LOX) correlates with metastatic dissemination to the bone in estrogen receptor negative breast cancer and is essential for the formation of premetastatic osteolytic lesions.
The lysyl oxidase inhibitor (β-aminopropionitrile) reduces leptin profibrotic effects and ameliorates cardiovascular remodeling in diet-induced obesity in rats.
New
Cachofeiro et al., Madrid, Spain. In J Mol Cell Cardiol, Feb 2016
UNASSIGNED: Lysyl oxidase (LOX) is an extracellular matrix (ECM)-modifying enzyme that has been involved in cardiovascular remodeling.
An Evaluation of Lysyl Oxidase-Derived Cross-Linking in Keratoconus by Liquid Chromatography/Mass Spectrometry.
New
Paik et al., New York City, United States. In Invest Ophthalmol Vis Sci, Feb 2016
The aim of the present study was to examine levels of enzymatic lysyl oxidase-derived cross-links in stromal collagen in KC tissue, and to correlate the cross-link levels with collagen fibril stability as determined by thermal denaturation temperature (Tm).
Analgesic and anti-inflammatory effects of UP1304, a botanical composite containing standardized extracts of Curcuma longa and Morus alba.
New
Jia et al., Seattle, United States. In J Integr Med, Jan 2016
In vitro, cyclooxygenase (COX) and lipoxygenase (LOX) inhibition assays were performed to evaluate the degree of inflammation.
Macrophage-mediated cholesterol handling in atherosclerosis.
Review
New
Orekhov et al., Moscow, Russia. In J Cell Mol Med, Jan 2016
Several scavenger receptors (SR), including CD36, SR-A1 and lectin-like oxLDL receptor-1 (LOX-1), mediate oxLDL uptake.
Membrane and inhibitor interactions of intracellular phospholipases A2.
Review
New
Dennis et al., San Diego, United States. In Adv Biol Regul, Jan 2016
The liberation of AA by PLA2 enzymes sets off a cascade of molecular events that involves downstream regulators such as cyclooxygenase (COX) and lipoxygenase (LOX) metabolites leading to inflammation.
A CRISPR/Cas9 and Cre/Lox system-based express vaccine development strategy against re-emerging Pseudorabies virus.
New
Cao et al., Wuhan, China. In Sci Rep, Dec 2015
Here we present an express vaccine development strategy based on CRISPR/Cas9 and Cre/Lox system against re-emerging Pseudorabies virus, which caused the recent devastating swine pseudorabies outbreak in China.
Interplay between CRP, Atherogenic LDL, and LOX-1 and Its Potential Role in the Pathogenesis of Atherosclerosis.
Review
New
Chen et al., Kao-hsiung, Taiwan. In Clin Chem, Dec 2015
A growing body of evidence has suggested that interplay between CRP, lectin-like oxidized LDL receptor-1 (LOX-1), and atherogenic LDL may underlie the mechanism of endothelial dysfunction that leads to atherosclerosis.
Eicosanoid pathway in colorectal cancer: Recent updates.
Review
New
Banerjee et al., Ankara, Turkey. In World J Gastroenterol, Dec 2015
Enzymatic metabolism of the 20C polyunsaturated fatty acid (PUFA) arachidonic acid (AA) occurs via the cyclooxygenase (COX) and lipoxygenase (LOX) pathways, and leads to the production of various bioactive lipids termed eicosanoids.
The hypoxic cancer secretome induces pre-metastatic bone lesions through lysyl oxidase.
New
Impact
Erler et al., Copenhagen, Denmark. In Nature, Jul 2015
Global quantitative analysis of the hypoxic secretome identified lysyl oxidase (LOX) as significantly associated with bone-tropism and relapse.
C-type lectin-like receptor LOX-1 promotes dendritic cell-mediated class-switched B cell responses.
Impact
Oh et al., Dallas, United States. In Immunity, 2014
Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is a pattern-recognition receptor for a variety of endogenous and exogenous ligands.
LOX-1 unlocks human plasma cell potential.
Impact
Brink, Australia. In Immunity, 2014
Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is best known for promoting atherosclerosis.
GATA3 suppresses metastasis and modulates the tumour microenvironment by regulating microRNA-29b expression.
Impact
Werb et al., San Francisco, United States. In Nat Cell Biol, 2013
Mechanistically, miR-29b inhibits metastasis by targeting a network of pro-metastatic regulators involved in angiogenesis, collagen remodelling and proteolysis, including VEGFA, ANGPTL4, PDGF, LOX and MMP9, and targeting ITGA6, ITGB1 and TGFB, thereby indirectly affecting differentiation and epithelial plasticity.
The rationale for targeting the LOX family in cancer.
Review
Impact
Erler et al., London, United Kingdom. In Nat Rev Cancer, 2012
Members of the lysyl oxidase (LOX) family of proteins are secreted by tumours and are the subject of much effort to understand their roles in cancer.
Vps18 deficiency inhibits dendritogenesis in Purkinje cells by blocking the lysosomal degradation of Lysyl Oxidase.
GeneRIF
Tao et al., Shanghai, China. In Biochem Biophys Res Commun, 2012
the lysyl oxidase (Lox) protein is degraded through lysosome and accumulated in the Vps18 deficient cerebellum but not in cerebral cortices.
Effect of mechanical stretch on the expressions of elastin, LOX and Fibulin-5 in rat BMSCs with ligament fibroblasts co-culture.
GeneRIF
Xi et al., Zhengzhou, China. In Mol Biol Rep, 2012
These results suggest that in an indirect co-culture system, pelvic ligament fibroblasts with mechanical stretch stimulation can promote bone mesenchymal stem cell differentiation, reflecting in the increased expression of elastin, LOX, and Fibulin-5.
Blimp1 activation by AP-1 in human lung cancer cells promotes a migratory phenotype and is inhibited by the lysyl oxidase propeptide.
GeneRIF
Sonenshein et al., Boston, United States. In Plos One, 2011
Blimp1 is a mediator of Ras/Raf/AP-1 signaling that promotes cell migration, and is repressed by LOX-PP in lung cancer.
Lysyl oxidase G473A polymorphism is closely associated with susceptibility to gastric cancer in a South Korean population.
GeneRIF
Park et al., Seoul, South Korea. In Apmis, 2011
G473A polymorphism of the lysyl oxidase gene may be closely associated with susceptibility to the development and differentiation of gastric cancer in South Korean patients.
TNF-α increases cardiac fibroblast lysyl oxidase expression through TGF-β and PI3Kinase signaling pathways.
GeneRIF
Gardner et al., New Orleans, United States. In Biochem Biophys Res Commun, 2011
These findings indicate that TNF-alpha stimulated LOX expression may play an important role in progressive cardiac fibrosis.
More papers using lysyl oxidase antibodies
A role for 12-lipoxygenase in nerve cell death caused by glutathione depletion
Supplier
Strosznajder Robert P. et al., In Neurochemical Research, 1996
... were obtained as follows: ECL reagents were purchased from GE Healthcare, Piscataway NJ, USA; anti-12/15 LOX antibody was obtained from Cayman Chemical, Ann Arbor MI, ...
Autooxidation of docosahexaenoic acid: analysis of ten isomers of hydroxydocosahexaenoate
Supplier
Maya-Monteiro Clarissa Menezes, In PLoS ONE, 1983
... DHA and AA (NuChek Prep); soybean 15-LOX type 1a (sLOX), sodium borate, and sodium borohydride (Sigma); HPLC columns (Waters); HPLC or optima grade organic solvents and diethyl ether (Fisher); anti-SDC-1 (H-174) antibody (Santa Cruz Biotechnology, Inc); anti-HRP-conjugated secondary antibody ...
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