Lysyl Oxidase, a Targetable Secreted Molecule Involved in Cancer Metastasis.
Copenhagen, Denmark. In Cancer Res, Feb 2016
Recently, we showed that hypoxic induction of the extracellular matrix modifying enzyme lysyl oxidase (LOX) correlates with metastatic dissemination to the bone in estrogen receptor negative breast cancer and is essential for the formation of premetastatic osteolytic lesions.
15-Lipoxygenase inhibitors: a patent review.
Mashhad, Iran. In Expert Opin Ther Pat, Dec 2015
Two types of the enzyme, 15-LOX-1 and 15-LOX-2, have been recognized in mammals to have different abilities in the peroxidation of arachidonic acid and linoleic acid.
Eicosanoid pathway in colorectal cancer: Recent updates.
Ankara, Turkey. In World J Gastroenterol, Dec 2015
Enzymatic metabolism of the 20C polyunsaturated fatty acid (PUFA) arachidonic acid (AA) occurs via the cyclooxygenase (COX) and lipoxygenase (LOX) pathways, and leads to the production of various bioactive lipids termed eicosanoids.
GATA3 suppresses metastasis and modulates the tumour microenvironment by regulating microRNA-29b expression.
More papers using
San Francisco, United States. In Nat Cell Biol, 2013
Mechanistically, miR-29b inhibits metastasis by targeting a network of pro-metastatic regulators involved in angiogenesis, collagen remodelling and proteolysis, including VEGFA, ANGPTL4, PDGF, LOX and MMP9, and targeting ITGA6, ITGB1 and TGFB, thereby indirectly affecting differentiation and epithelial plasticity.