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Lysophospholipase-like 1

LYPLAL1, lysophospholipase-like 1
Top mentioned proteins: fibrillin-1, AGE, AP-2beta, FTO, GCKR
Papers on LYPLAL1
Gene × dietary pattern interactions in obesity: analysis of up to 68 317 adults of European ancestry.
New
Franks et al., Houston, United States. In Hum Mol Genet, Sep 2015
were observed between the diet score and WHR-GRS (but not BMI-GRS), two WHR loci (GRB14 rs10195252; LYPLAL1 rs4846567) and two BMI loci (LRRN6C rs10968576; MTIF3 rs4771122), for the respective BMI-adjusted WHR or BMI outcomes.
Obesity associated Lyplal1 gene is regulated in diet induced obesity but not required for adipocyte differentiation.
New
Chen et al., Changsha, China. In Mol Cell Endocrinol, Sep 2015
Recent genome-wide association studies (GWAS) have identified several variants in LYPLAL1 gene that are significantly associated with central obesity preferentially in females.
A genetic risk score is associated with hepatic triglyceride content and non-alcoholic steatohepatitis in Mexicans with morbid obesity.
New
Canizales-Quinteros et al., Mexico. In Exp Mol Pathol, Apr 2015
BACKGROUND AND AIMS: Genome-wide association studies have identified single nucleotide polymorphisms (SNPs) near/in PNPLA3, NCAN, LYPLAL1, PPP1R3B, and GCKR genes associated with non-alcoholic fatty liver disease (NAFLD) mainly in individuals of European ancestry.
Multi-ethnic fine-mapping of 14 central adiposity loci.
Adrienne Cupples et al., Chapel Hill, United States. In Hum Mol Genet, 2014
Trans-ethnic analyses at five loci (TBX15-WARS2, LYPLAL1, ADAMTS9, LY86 and ITPR2-SSPN) substantially narrowed the signals to smaller sets of variants, some of which are in regions that have evidence of regulatory activity.
Genetic risk profiles for a childhood with severe overweight.
Rodríguez-López et al., Barcelona, Spain. In Pediatr Obes, 2014
109 SNPs located in the genes FTO, SEC16B, BDNF, ETV5, SH2B1, GNPDA2, LYPLAL1, MSRA, TFAP2, KCTD15, MTCH2 and NEGR1, previously reported in association to body mass index (BMI) were analysed.
Moderate to vigorous physical activity interactions with genetic variants and body mass index in a large US ethnically diverse cohort.
Gordon-Larsen et al., Chapel Hill, United States. In Pediatr Obes, 2014
Race/ethnicity-pooled meta-analysis showed nominally significant interactions for SNPs at TFAP2B, POC5 and LYPLAL1.
Genetic variants in GCKR and PNPLA3 confer susceptibility to nonalcoholic fatty liver disease in obese individuals.
Ni et al., Taipei, Taiwan. In Am J Clin Nutr, 2014
BACKGROUND: A genome-wide association study identified variants in or near patatin-like phospholipase domain-containing-3 (PNPLA3), neurocan (NCAN), lysophospholipase-like 1 (LYPLAL1), glucokinase regulatory protein (GCKR), and protein phosphatase 1 regulatory subunit 3b (PPP1R3B) that were strongly associated with nonalcoholic fatty liver disease (NAFLD) in adults of European ancestry.
The postprandial chylomicron triacylglycerol response to dietary fat in healthy male adults is significantly explained by a combination of single nucleotide polymorphisms in genes involved in triacylglycerol metabolism.
Borel et al., Marseille, France. In J Clin Endocrinol Metab, 2014
RESULTS: Data obtained allowed us to generate a validated significant model (P = 1.3 × 10(-7)) that included 42 SNPs in 23 genes (ABCA1, APOA1, APOA5, APOB, BET1, CD36, COBLL1, ELOVL5, FRMD5, GPAM, INSIG2, IRS1, LDLR, LIPC, LPL, LYPLAL1, MC4R, NAT2, PARK2, SLC27A5, SLC27A6, TCF7L2, and ZNF664) and explained 88% of the variance.
Association of polymorphisms in GCKR and TRIB1 with nonalcoholic fatty liver disease and metabolic syndrome traits.
Hotta et al., Kyoto, Japan. In Endocr J, 2013
In several genome-wide association studies, nonalcoholic fatty liver disease and alanine aminotransferase susceptibility variants have been identified in several genes, including LYPLAL1, ZP4, GCKR, HSD17B13, PALLD, PPP1R3B, FDFT1, TRIB1, COL13A1, CPN1, ERLIN1, CWF19L1, EFCAB4B, PZP, and NCAN.
Characterization of European ancestry nonalcoholic fatty liver disease-associated variants in individuals of African and Hispanic descent.
Speliotes et al., Winston-Salem, United States. In Hepatology, 2013
Variants in/near PNPLA3, NCAN, LYPLAL1, GCKR, and PPP1R3B were tested for association with hepatic steatosis using a regression framework in each cohort and meta-analyzed.
Systematic evaluation of validated type 2 diabetes and glycaemic trait loci for association with insulin clearance.
Rotter et al., Los Angeles, United States. In Diabetologia, 2013
The top signals for each locus were rs10241087 (DGKB/TMEM195 [TMEM195 also known as AGMO]) (p = 4.4 × 10(-5)); chr1:217605433 (LYPLAL1) (p = 3.25 × 10(-4)); rs2380949 (GLIS3) (p = 3.4 × 10(-4)); rs55903902 (FADS1) (p = 5.6 × 10(-4)); rs849334 (JAZF1) (p = 6.4 × 10(-4)); rs35749 (IGF1) (p = 6.7 × 10(-4)); and rs9460557 (CDKAL1) (p = 6.8 × 10(-4)).
Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits.
Heid et al., Cambridge, United Kingdom. In Plos Genet, 2013
Seven loci displayed significant sex-difference (FDR<5%), including four previously established (near GRB14/COBLL1, LYPLAL1/SLC30A10, VEGFA, ADAMTS9) and three novel anthropometric trait loci (near MAP3K1, HSD17B4, PPARG), all of which were genome-wide significant in women (P<5×10(-8)), but not in men.
Genetic variation at NCAN locus is associated with inflammation and fibrosis in non-alcoholic fatty liver disease in morbid obesity.
GOLD Consortium et al., Baltimore, United States. In Hum Hered, 2012
In a previously reported genome-wide association meta-analysis, single nucleotide polymorphisms (SNPs) near PNPLA3, NCAN, GCKR, LYPLAL1 and PPP1R3B were associated with NAFLD and with distinctive serum lipid profiles.
PNPLA3 GG genotype and carotid atherosclerosis in patients with non-alcoholic fatty liver disease.
Craxì et al., Palermo, Italy. In Plos One, 2012
IL28B rs12979860 C>T, PNPLA3 rs738409 C>G, GCKR rs780094 C>T, LYPLAL1 rs12137855 C>T, and NCAN rs2228603 C>T single nucleotide polymorphisms were also assessed.
Genetic predictors of weight loss and weight regain after intensive lifestyle modification, metformin treatment, or standard care in the Diabetes Prevention Program.
GeneRIF
Diabetes Prevention Program Research Group et al., Boston, United States. In Diabetes Care, 2012
Gene-treatment interactions were observed for short-term weight loss. (LYPLAL1 rs2605100, Plifestyle*SNP = 0.032)
Association studies of novel obesity-related gene variants with quantitative metabolic phenotypes in a population-based sample of 6,039 Danish individuals.
GeneRIF
Pedersen et al., Copenhagen, Denmark. In Diabetologia, 2012
genetic association studies in Danish population: Quantitative metabolic phenotypes in obesity are associated with SNP in various genes: LYPLAL1 (rs4846567) is associated with waist-hip ratio and insulin sensitivity in women.
Crystal structure of the predicted phospholipase LYPLAL1 reveals unexpected functional plasticity despite close relationship to acyl protein thioesterases.
GeneRIF
Vetter et al., Dortmund, Germany. In J Lipid Res, 2012
LYPLAL1 exhibits neither phospholipase nor triacylglycerol lipase activity, but rather accepts short-chain substrates
Implications of central obesity-related variants in LYPLAL1, NRXN3, MSRA, and TFAP2B on quantitative metabolic traits in adult Danes.
GeneRIF
Pedersen et al., Copenhagen, Denmark. In Plos One, 2010
central obesity-associated variants in LYPLAL1, NRXN3, MSRA, and TFAP2B
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution.
Impact
Lindgren et al., Regensburg, Germany. In Nat Genet, 2010
We identified 13 new loci in or near RSPO3, VEGFA, TBX15-WARS2, NFE2L3, GRB14, DNM3-PIGC, ITPR2-SSPN, LY86, HOXC13, ADAMTS9, ZNRF3-KREMEN1, NISCH-STAB1 and CPEB4 (P = 1.9 × 10⁻⁹ to P = 1.8 × 10⁻⁴⁰) and the known signal at LYPLAL1.
Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution.
GeneRIF
Giant Consortium et al., Oxford, United Kingdom. In Plos Genet, 2009
TFAP2B, LYPLAL1 and MSRA are associated with adiposity and fat distribution.
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