GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 19 Dec 2016.
Protein tyrosine phosphatase, non-receptor type 22
PTPN22, LYP
This gene encodes of member of the non-receptor class 4 subfamily of the protein-tyrosine phosphatase family. The encoded protein is a lymphoid-specific intracellular phosphatase that associates with the molecular adapter protein CBL and may be involved in regulating CBL function in the T-cell receptor signaling pathway. Mutations in this gene may be associated with a range of autoimmune disorders including Type 1 Diabetes, rheumatoid arthritis, systemic lupus erythematosus and Graves' disease. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Mar 2009] (from
NCBI)
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CTLA-4, CAN, HAD, AGE, DRB1
Papers on
PTPN22
Meta-analysis reveals PTPN22 1858C/T polymorphism confers susceptibility to rheumatoid arthritis in Caucasian but not in Asian population.
New
Jīzān, Saudi Arabia. In Autoimmunity, Feb 2016
UNASSIGNED: The PTPN22 1858C/T polymorphism is associated with rheumatoid arthritis (RA).
Negative regulation of TLR signaling in myeloid cells-implications for autoimmune diseases.
Review
New
Seattle, United States. In Immunol Rev, Jan 2016
Here, we highlight three pathways that participate in inhibition of TLR responses in macrophages and DC, and their implications in autoimmunity; A20, encoded by the TNFAIP3 gene, Lyp encoded by the PTPN22 gene, and the BCAP/PI3K pathway.
Targeted Deep Sequencing in Multiple-Affected Sibships of European Ancestry Identifies Rare Deleterious Variants in PTPN22 that Confer Risk for Type 1 Diabetes.
New
Gainesville, United States. In Diabetes, Jan 2016
The risk allele at rs56048322 affects splicing of PTPN22 resulting in the production of two alternative PTPN22 transcripts and a novel isoform of LYP (the protein encoded by PTPN22).
Association between PTPN22 C1858T polymorphism and alopecia areata risk.
New
Saltillo, Mexico. In Exp Ther Med, Nov 2015
The gene encoding the protein tyrosine phosphatase, non-receptor type 22 (PTPN22), which is exclusively expressed in immune cells, has been considered as a risk factor associated with a number of autoimmune diseases.
The Genotype and Phenotype (GaP) registry: a living biobank for the analysis of quantitative traits.
Review
New
United States. In Immunol Res, Nov 2015
The GaP has facilitated functional studies of several autoimmune disease associated loci including Csk, Blk, PDRM1 (Blimp-1) and PTPN22.
Representative Amino Acid Side-Chain Interactions in Protein-DNA Complexes: A Comparison of Highly Accurate Correlated Ab Initio Quantum Mechanical Calculations and Efficient Approaches for Applications to Large Systems.
New
Praha, Czech Republic. In J Chem Theory Comput, Oct 2015
B3-LYP-D3 calculated with def2-TZVPP and def2-QZVP basis sets yielded sufficiently good results with a reasonably small RMSE.
The Association between PTPN22 Genetic Polymorphism and Juvenile Idiopathic Arthritis (JIA) Susceptibility: An Updated Meta-Analysis.
Review
New
China. In Iran J Public Health, Sep 2015
BACKGROUND: Limited studies have focused on the association between the protein tyrosine phosphates non-receptor type 22 (PTPN22) genetic polymorphisms and Juvenile idiopathic arthritis (JIA) susceptibility in different populations, but the results were inconclusive.
Heterogeneity of autoimmune diseases: pathophysiologic insights from genetics and implications for new therapies.
Review
New
Impact
New York City, United States. In Nat Med, Jul 2015
Here we discuss our current understanding of the shared pathways of autoimmunity, including the tumor necrosis factor (TNF), major histocompatibility complex (MHC), interleukin 23 receptor (IL23R) and protein tyrosine phosphatase non-receptor type 22 (PTPN22) pathways.
Genetic studies of rheumatoid arthritis.
Review
Tokyo, Japan. In Proc Jpn Acad Ser B Phys Biol Sci, 2014
In addition, we discuss the pathologic mechanisms of RA as suggested by the findings of genetic and functional studies of individual RA-associated genes, including HLA-DRB1, PADI4, PTPN22, CCR6 and FCRL3, and the potential use of genetic information for RA treatment in clinical practice.
Genetic Variations of PTPN2 and PTPN22: Role in the Pathogenesis of Type 1 Diabetes and Crohn's Disease.
Review
Orlando, United States. In Front Cell Infect Microbiol, 2014
This review article is focused on the impact of SNP's in PTPN2 (protein tyrosine phosphatase, non-receptor type 2) and PTPN22 (protein tyrosine phosphatase non-receptor type 22) on the development of Crohn's disease and T1D.
Association of TNF-α, CTLA4, and PTPN22 polymorphisms with type 1 diabetes and other autoimmune diseases in Brazil.
Recife, Brazil. In Genet Mol Res, 2014
Polymorphisms in the TNF-α(rs1800629), CTLA-4 (rs231775), and PTPN22 (rs2476601) genes have been previous associated with T1D; however, there is no consensus regarding their role in T1D and scarce literature focusing on AIDT and/or CD.
The tyrosine phosphatase PTPN22 discriminates weak self peptides from strong agonist TCR signals.
Impact
Edinburgh, United Kingdom. In Nat Immunol, 2014
We found that in both naive T cells and effector T cells, the tyrosine phosphatase PTPN22 limited signaling via the T cell antigen receptor (TCR) by weak agonists and self antigens while not impeding responses to strong agonist antigens.
Tyrosine phosphatase PTPN22: multifunctional regulator of immune signaling, development, and disease.
Review
Impact
Los Angeles, United States. In Annu Rev Immunol, 2013
Inheritance of a coding variant of the protein tyrosine phosphatase nonreceptor type 22 (PTPN22) gene is associated with increased susceptibility to autoimmunity and infection.
The autoimmunity-associated gene PTPN22 potentiates toll-like receptor-driven, type 1 interferon-dependent immunity.
Impact
Minneapolis, United States. In Immunity, 2013
A coding polymorphism in the protein tyrosine phosphatase nonreceptor type 22 (PTPN22) gene is a susceptibility allele for human autoimmune and infectious disease.
PTPN22 in autoimmunity: different cell and different way.
Impact
New York City, United States. In Immunity, 2013
The tyrosine phosphatase PTPN22 regulates T cell receptor signaling.
PTPN22 C1858T and the risk of psoriasis: a meta-analysis.
GeneRIF
Taiwan. In Mol Biol Rep, 2012
The current analysis showed a non-significantly positive association between psoriasis and the PTPN22 T1858 allele, and the association appeared stronger among subjects with psoriatic arthritis.
The protein tyrosine phosphatase nonreceptor 22 C1858T polymorphism and vasculitis: a meta-analysis.
GeneRIF
Seoul, South Korea. In Mol Biol Rep, 2012
This meta-analysis does not show that the PTPN22 C1858T polymorphism is associated with vasculitis susceptibility, but does show that this polymorphism is associated with susceptibility to AAV, WG, and ANCA status in WG.
The PTPN22 C1858T variant as a risk factor for rheumatoid arthritis and systemic lupus erythematosus but not for systemic sclerosis in the Colombian population.
GeneRIF
Bogotá, Colombia. In Clin Exp Rheumatol, 2012
The PTPN22 1858T variant influences rheumatoid arthritis and systemic lupus genetic background but not that of systemic sclerosis in the Colombian population.
Overexpression of the autoimmunity-associated phosphatase PTPN22 promotes survival of antigen-stimulated CLL cells by selectively activating AKT.
GeneRIF
Roma, Italy. In Blood, 2012
PTPN22 overexpression represents a protective mechanism that allows autoantigen-activated CLL cells to escape from negative selection.
R620W functional polymorphism of protein tyrosine phosphatase non-receptor type 22 is not associated with pulmonary tuberculosis in Zahedan, southeast Iran.
GeneRIF
Zāhedān, Iran. In Genet Mol Res, 2011
study found that the PTPN22 C1858T (R620W) is not involved in the susceptibility to pulmonary tuberculosis in Iranian patients
