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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

V-yes-1 Yamaguchi sarcoma viral related oncogene homolog

This gene encodes a tyrosine protein kinase, which maybe involved in the regulation of mast cell degranulation, and erythroid differentiation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011] (from NCBI)
Top mentioned proteins: Src, Syk, CAN, BCR, alpha-Synuclein
Papers using Lyn antibodies
A critical role for Lyn in acute myeloid leukemia
Dai Zonghan et al., In Carcinogenesis, 2007
... The antibodies against WAVE2, Lyn and phosphotyrosine-containing proteins were purchased from Santa Cruz Biotechnology (Santa Cruz, CA) and ...
IQGAP2 inactivation through aberrant promoter methylation and promotion of invasion in gastric cancer cells
Jiang Bo et al., In Molecular Cancer, 2007
... The phospho-Lyn (Y396) antibody was purchased from Abcam (Cambridge, MA) ...
Suppressive effects of statins on acute promyelocytic leukemia cells
Heymann Dominique, In PLoS ONE, 2006
... Anti-transferrin receptor (CD71) was provided by BD Biosciences (San Jose, CA, USA); anti-Lyn antibody was from Abcam (Cambridge, UK) ...
Soluble Abeta oligomers ultrastructurally localize to cell processes and might be related to synaptic dysfunction in Alzheimer's disease brain
Combs Colin K et al., In Journal of Neuroinflammation, 2004
... Anti-phospho-p38, anti-p38, anti-phospho-JNK, anti-JNK, and anti-phospho-Lyn were from Cell Signaling (Beverly, MA) ...
Clathrin-independent endocytosis of ubiquitinated cargos.
Gruenberg Jean, In PLoS ONE, 2004
... Rabbit anti-Eps15 and anti-Lyn 44 polyclonal Abs and mouse anti-Ub P4D1 and anti-clathrin heavy chain mAbs were purchased from Santa Cruz Biotechnology (Santa Cruz, CA) ...
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Papers on Lyn
Ikaros limits follicular B cell activation by deregulating B cell receptor signaling pathways.
Kastner et al., Illkirch-Graffenstaden, France. In Biochem Biophys Res Commun, Feb 2016
Unstimulated mutant B cells show deregulation of positive and negative regulators of signal transduction at the mRNA level, and constitutive phosphorylation of ERK, p38, SYK, BTK, AKT and LYN.
Src family kinase expression and subcellular localization in macrophages: implications for their role in CSF-1-induced macrophage migration.
Pixley et al., Australia. In J Leukoc Biol, Feb 2016
Hck associated with the activated colony-stimulating factor-1 receptor, whereas Lyn associated with the receptor in a constitutive manner.
Quantitative proteomics reveals protein kinases and phosphatases in the individual phases of contextual fear conditioning in the C57BL/6J mouse.
Li et al., Vienna, Austria. In Behav Brain Res, Jan 2016
In addition, our analysis showed protein kinases WNK1, LYN, VRK1, ABL1, CDK4, CDKL3, SgK223 and ADCK1, and protein phosphatases PTPRF, ACP1, DNAJC6, SSH2 and UBASH3B that have not been directly linked to fear memory processes so far.
The PPI network and clusters analysis in glioblastoma.
Ma et al., Chengdu, China. In Eur Rev Med Pharmacol Sci, Dec 2015
LYN, CD22 and LCP2 form a densely protein complex in the PPI network.
Identification of novel genes and pathways in carotid atheroma using integrated bioinformatic methods.
Dai et al., Guangzhou, China. In Sci Rep, Dec 2015
Protein-protein interaction network and module analysis demonstrated that VAV1, SYK, LYN and PTPN6 may play critical roles in the network.
FCRL regulation in innate-like B cells.
Davis, Birmingham, United States. In Ann N Y Acad Sci, Dec 2015
Closer scrutiny of these differences disclosed the ability of FCRL5 to counter-regulate BCR activation by recruiting SHP-1 and Lyn to its cytoplasmic motifs.
Astaxanthin Improves Human Sperm Capacitation by Inducing Lyn Displacement and Activation.
Bordin et al., Padova, Italy. In Mar Drugs, Sep 2015
In addition, the involvement of ROS on membrane reorganization and the presence of Lyn, a Src family kinase associated with lipid rafts, were investigated.
Membrane lipid rafts, master regulators of hematopoietic stem cell retention in bone marrow and their trafficking.
Adamiak et al., Louisville, United States. In Leukemia, Jul 2015
These structures have an important role in assembling signaling molecules (e.g., Rac-1, RhoH and Lyn) together with surface receptors, such as the CXCR4 receptor for α-chemokine stromal-derived factor-1, the α4β1-integrin receptor (VLA-4) for vascular cell adhesion molecule-1 and the c-kit receptor for stem cell factor, which together regulate several aspects of hematopoietic stem/progenitor cell (HSPC) biology.
Fyn in Neurodevelopment and Ischemic Brain Injury.
Jiang et al., New York City, United States. In Dev Neurosci, 2014
The SFKs Fyn, Src, Yes, Lyn, and Lck are expressed in the brain.
The role of dasatinib in the management of chronic myeloid leukemia.
Chen et al., Nanjing, China. In Drug Des Devel Ther, 2014
It potently inhibits BCR/ABL and SRC-family kinases (SRC, LCK, HCK, YES, FYN, FGR, BLK, LYN, FRK), as well as c-KIT, PDGFR-a and -b, and ephrin receptor kinase.
Epidermal growth factor receptor potentiates MCM7-mediated DNA replication through tyrosine phosphorylation of Lyn kinase in human cancers.
Hung et al., Houston, United States. In Cancer Cell, 2013
Here, we show that activated EGFR phosphorylates the p56 isoform of Lyn, p56(Lyn), at Y32, which then phosphorylates MCM7, a licensing factor critical for DNA replication, at Y600 to increase its association with other minichromosome maintenance complex proteins, thereby promoting DNA synthesis complex assembly and cell proliferation.
Cholesterol efflux in megakaryocyte progenitors suppresses platelet production and thrombocytosis.
Wang et al., New York City, United States. In Nat Med, 2013
These consequences of ABCG4 deficiency seemed to reflect disruption of negative feedback regulation of c-MPL signaling by the E3 ligase c-CBL and the cholesterol-sensing LYN kinase.
CSK regulatory polymorphism is associated with systemic lupus erythematosus and influences B-cell signaling and activation.
Gregersen et al., Long Beach, United States. In Nat Genet, 2012
The c-Src tyrosine kinase, Csk, physically interacts with the intracellular phosphatase Lyp (encoded by PTPN22) and can modify the activation state of downstream Src kinases, such as Lyn, in lymphocytes.
Interactions among HCLS1, HAX1 and LEF-1 proteins are essential for G-CSF-triggered granulopoiesis.
Welte et al., Hannover, Germany. In Nat Med, 2012
We found that hematopoietic cell-specific Lyn substrate 1 (HCLS1 or HS1) is highly expressed in human myeloid cells and that stimulation with granulocyte colony-stimulating factor (G-CSF) leads to HCLS1 phosphorylation.
Genetic interdependence of Lyn and negative regulators of B cell receptor signaling in autoimmune disease development.
Hibbs et al., Melbourne, Australia. In J Immunol, 2012
This study demonstrates that Lyn is a haploinsufficient gene in autoimmune disease
DOCK8 functions as an adaptor that links TLR-MyD88 signaling to B cell activation.
Geha et al., Boston, United States. In Nat Immunol, 2012
After ligation of TLR9, DOCK8 became tyrosine-phosphorylated by Pyk2, bound the Src-family kinase Lyn and linked TLR9 to a Src-kinase Syk-transcription factor STAT3 cascade essential for TLR9-driven B cell proliferation and differentiation.
Lyn kinase mediates cell motility and tumor growth in EGFRvIII-expressing head and neck cancer.
Grandis et al., Pittsburgh, United States. In Clin Cancer Res, 2012
findings show that Lyn mediates tumor progression of EGFRvIII-expressing head and neck squamous cell carcinomas
Lyn-dependent signaling regulates the innate immune response by controlling dendritic cell activation of NK cells.
Harder et al., Vancouver, Canada. In J Immunol, 2012
Lyn enhances endotoxin-induced dendritic cell (DC) maturation and modified DC cytokine expression profiles, leading to elevated natural killer (NK) cell IFN-gamma production.
Lyn but not Fyn kinase controls IgG-mediated systemic anaphylaxis.
Ryan et al., Richmond, United States. In J Immunol, 2012
Lyn but not Fyn kinase controls IgG-mediated systemic anaphylaxis.
Nef alleles from all major HIV-1 clades activate Src-family kinases and enhance HIV-1 replication in an inhibitor-sensitive manner.
Smithgall et al., Pittsburgh, United States. In Plos One, 2011
the activation of Hck, Lyn and c-Src by Nef is highly conserved among all major clades of HIV-1
More papers using Lyn antibodies
Genome-wide analysis of membrane targeting by S. cerevisiae pleckstrin homology domains
Irvine Robin F. et al., In The Journal of Cell Biology, 2003
... PM-YFP is the palmitoylated/myristoylated N-terminal 11 residues of human Lyn kinase (MGCIKSKGKDS) cloned into pEYFP-N1 (Clontech Laboratories, Inc.) at EcoR1–BamH1 ...
Image Processing with ImageJ.
Gasset Maria, In PLoS ONE, 2003
... Rabbit anti-Lyn (Lyn 44) polyclonal antibodies were purchased from Santa Cruz Biotechnology (Santa Cruz, CA) ...
Measuring chemotaxis and chemokinesis: the under-agarose cell migration assay
Huttenlocher Anna et al., In Nature, 2002
... Multiple roles of Lyn kinase in myeloid cell signaling and function ...
Trafficking of Lyn through the Golgi caveolin involves the charged residues on αE and αI helices in the kinase domain
Yamaguchi Naoto et al., In The Journal of Cell Biology, 1998
... Lyn-GFP and Tetra-mt-GFP was constructed by fusion with GFP obtained from pEGFP-C1 (CLONTECH Laboratories, Inc.) at the ...
Transfection of Syk protein tyrosine kinase reconstitutes high affinity IgE receptor–mediated degranulation in a Syk-negative variant of rat basophilic leukemia RBL-2H3 cells
Baird Barbara et al., In The Journal of Cell Biology, 1995
... ), specific for the GPI-anchored protein Thy-1; and anti-Lyn (Upstate Biotechnology, Inc., and Santa Cruz Biotechnology ...
Generation of an active protein-tyrosine kinase from lymphocytes by proteolysis
Wienands Jürgen et al., In The EMBO Journal, 1987
... used according to manufacturer's instructions and recognized SLP65, CD2AP, Grb-2, Sek1, Syk, phosphorylated Syk and Lyn (all Cell Signaling Technologies/BD Biosciences), CapZ and ...
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