Lymphoid Enhancer-Binding Factor 1
Targeting the β-catenin nuclear transport pathway in cancer.
Sydney, Australia. In Semin Cancer Biol, 2014
In response to a wnt stimulus or specific gene mutations, β-catenin is stabilized and translocates to the nucleus where it binds TCF/LEF-1 transcription factors to transactivate genes that drive tumor formation.
A molecular basis for classic blond hair color in Europeans.
Stanford, United States. In Nat Genet, 2014
This enhancer contains a common SNP (rs12821256) that alters a binding site for the lymphoid enhancer-binding factor 1 (LEF1) transcription factor, reducing LEF1 responsiveness and enhancer activity in cultured human keratinocytes.
Through the glass darkly: intraepithelial neoplasia, top-down differentiation, and the road to ovarian cancer.
Boston, United States. In J Pathol, 2013
Both direct and indirect ('surrogate') precursors suggest that the benign tube undergoes important biological changes after menopause, acquiring abnormalities in gene expression that are often shared with malignancy, including PAX2, ALDH1, LEF1, RCN1, RUNX2, beta-catenin, EZH2, and others.