LYL-1 deficiency induces a stress erythropoiesis.
Villejuif, France. In Exp Hematol, 2011
results suggest that LYL-1 plays a definite role in erythropoiesis, albeit with different effects in bone marrow specifically regulating basal erythropoiesis, and spleen, controlling stress-induced erythropoiesis
Combinatorial transcriptional control in blood stem/progenitor cells: genome-wide analysis of ten major transcriptional regulators.
Cambridge, United Kingdom. In Cell Stem Cell, 2010
Here, we report the genome-wide binding patterns and combinatorial interactions for ten key regulators of blood stem/progenitor cells (SCL/TAL1, LYL1, LMO2, GATA2, RUNX1, MEIS1, PU.1, ERG, FLI-1, and GFI1B), thus providing the most comprehensive TF data set for any adult stem/progenitor cell type to date.
Gene expression profiling in T-cell acute lymphoblastic leukemia.
Boston, United States. In Semin Hematol, 2003
Five different multistep molecular pathways have been identified that lead to T-ALL, involving activation of different T-ALL oncogenes: (1) HOX11, (2) HOX11L2, (3) TAL1 plus LMO1/2, (4) LYL1 plus LMO2, and (5) MLL-ENL.
Absence of blood formation in mice lacking the T-cell leukaemia oncoprotein tal-1/SCL.
Boston, United States. In Nature, 1995
In human T-cell leukaemias such regulators belong to diverse protein families and may normally be expressed widely (for example, Ttg-1/rbtn1, Ttg-2/rbtn2), exclusively outside the haematopoietic system (for example, Hox11), or specifically in haematopoietic cells and other selected sites (for example, tal-1/SCL, lyl-1).