Nonclassical patrolling monocyte function in the vasculature.
Los Angeles, United States. In Arterioscler Thromb Vasc Biol, Jun 2015
Patrolling monocyte subsets (CX3CR1(high)Ly6C(-) in mouse and CX3CR1(high)CD14(dim)CD16(+) in humans) are distinct from the classical monocyte subsets (CCR2(high)Ly6C(+) in mouse and CCR2(high)CD14(+)CD16(-) in humans) and exhibit unique functions in the vasculature and inflammatory disease.
Monocytes in myocardial infarction.
Boston, United States. In Arterioscler Thromb Vasc Biol, May 2015
The first phase is dominated by Ly-6c(high) monocytes and the second phase by Ly-6c(low) monocytes.
Proteus mirabilis: The Enemy Within.
Bethesda, United States. In Immunity, May 2015
In this issue of Immunity, Seo et al. (2015) show that the pathobiont Proteus mirabilis induces NLRP3 inflammasome-dependent interleukin-1β (IL-1β) release from CCR2(+) Ly6C(high) inflammatory monocytes.
Inflammatory monocyte effector mechanisms.
United States. In Cell Immunol, 2014
Among blood monocytes, the most abundant subset in mice is represented by inflammatory Ly6C(+) CCR2(+) monocytes and is the functional equivalent of the CD14(+) monocytes in humans.
Origin and functions of tissue macrophages.
Saint Louis, United States. In Immunity, 2014
Classical Ly6c(hi) monocytes patrol the extravascular space in resting organs, and Ly6c(lo) nonclassical monocytes patrol the vasculature.