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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Lymphocyte antigen 6 complex, locus C1

Ly-6C
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Top mentioned proteins: CD11b, CAN, HAD, V1a, CD4
Papers on Ly-6C
C1q Modulates the Response to TLR7 Stimulation by Pristane-Primed Macrophages: Implications for Pristane-Induced Lupus.
New
Botto et al., London, United Kingdom. In J Immunol, Feb 2016
Intraperitoneal injection of pristane induces a lupus-like syndrome whose pathogenesis implicates the secretion of type I IFN by CD11b(+) Ly6C(high) inflammatory monocytes in a TLR7-dependent fashion.
Local GM-CSF-Dependent Differentiation and Activation of Pulmonary Dendritic Cells and Macrophages Protect against Progressive Cryptococcal Lung Infection in Mice.
New
Osterholzer et al., Ann Arbor, United States. In J Immunol, Feb 2016
In contrast, GM-CSF deficiency resulted in increased accumulation of DC and Mϕ precursors, namely Ly-6C(high) monocytes, in the blood and lungs of infected mice.
Spatiotemporal Characterization of the Cellular and Molecular Contributors to Liver Fibrosis in a Murine Hepatotoxic-Injury Model.
New
MacDonald et al., Brisbane, Australia. In Am J Pathol, Feb 2016
In contrast, colony-stimulating factor 1 receptor blockade diminished C-C chemokine receptor type 2 [CCR2(neg) (Ly6C(lo))] monocytes, attenuated the DR, and significantly reduced fibrosis, illustrating the critical role of colony-stimulating factor 1-dependent monocyte/macrophage differentiation and linking the two phases of injury.
Interleukin-1 Receptor Activation Potentiates Salt Reabsorption in Angiotensin II-Induced Hypertension via the NKCC2 Co-transporter in the Nephron.
New
Impact
Crowley et al., Durham, United States. In Cell Metab, Jan 2016
In this setting, IL-1R1 activation prevents intra-renal myeloid cells from maturing into Ly6C(+)Ly6G(-) macrophages that elaborate nitric oxide, a natriuretic hormone that suppresses NKCC2 activity.
Moderate (2%, v/v) Ethanol Feeding Alters Hepatic Wound Healing after Acute Carbon Tetrachloride Exposure in Mice.
New
Pritchard et al., Kansas City, United States. In Biomolecules, Dec 2015
Inflammation, measured by TNFα mRNA and protein and hepatic Ly6c transcript accumulation, was reduced and associated with enhanced hepatocyte apoptosis after ethanol feeding.
Chemical dampening of Ly6C(hi) monocytes in the periphery produces anti-depressant effects in mice.
New
Hao et al., Nanjing, China. In Sci Rep, Dec 2015
Here we report that targeting Ly6C(hi) monocytes in blood can serve as a strategy for anti-depressant purpose.
The Cytokine GM-CSF Drives the Inflammatory Signature of CCR2+ Monocytes and Licenses Autoimmunity.
New
Impact
Becher et al., Zürich, Switzerland. In Immunity, Oct 2015
Instead, deletion of Csf2rb in CCR2(+)Ly6C(hi) monocytes phenocopied the EAE resistance seen in complete Csf2rb-deficient mice.
Identification of cDC1- and cDC2-committed DC progenitors reveals early lineage priming at the common DC progenitor stage in the bone marrow.
New
Impact
Ginhoux et al., Singapore, Singapore. In Nat Immunol, Jul 2015
We also identified Siglec-H and Ly6C as lineage markers that distinguished pre-DC subpopulations committed to the cDC1 lineage (Siglec-H(-)Ly6C(-) pre-DCs) or cDC2 lineage (Siglec-H(-)Ly6C(+) pre-DCs).
Bone-Marrow-Resident NK Cells Prime Monocytes for Regulatory Function during Infection.
New
Impact
Belkaid et al., Bethesda, United States. In Immunity, Jul 2015
Tissue-infiltrating Ly6C(hi) monocytes play diverse roles in immunity, ranging from pathogen killing to immune regulation.
Nonclassical patrolling monocyte function in the vasculature.
Review
New
Hanna et al., Los Angeles, United States. In Arterioscler Thromb Vasc Biol, Jun 2015
Patrolling monocyte subsets (CX3CR1(high)Ly6C(-) in mouse and CX3CR1(high)CD14(dim)CD16(+) in humans) are distinct from the classical monocyte subsets (CCR2(high)Ly6C(+) in mouse and CCR2(high)CD14(+)CD16(-) in humans) and exhibit unique functions in the vasculature and inflammatory disease.
Monocytes in myocardial infarction.
Review
New
Nahrendorf et al., Boston, United States. In Arterioscler Thromb Vasc Biol, May 2015
The first phase is dominated by Ly-6c(high) monocytes and the second phase by Ly-6c(low) monocytes.
Proteus mirabilis: The Enemy Within.
New
Impact
Trinchieri et al., Bethesda, United States. In Immunity, May 2015
In this issue of Immunity, Seo et al. (2015) show that the pathobiont Proteus mirabilis induces NLRP3 inflammasome-dependent interleukin-1β (IL-1β) release from CCR2(+) Ly6C(high) inflammatory monocytes.
Monocytes, Macrophages and Other Inflammatory Mediators of Abdominal Aortic Aneurysm.
Review
Tedgui et al., Paris, France. In Curr Pharm Des, 2014
Recent findings have shown that Ly-6C(high) and Ly-6C(low) monocytes are rapidly mobilized from the splenic reservoir in response to angiotensin II infusion and sequentially infiltrate the abdominal aorta.
Inflammatory monocyte effector mechanisms.
Review
Soudja et al., United States. In Cell Immunol, 2014
Among blood monocytes, the most abundant subset in mice is represented by inflammatory Ly6C(+) CCR2(+) monocytes and is the functional equivalent of the CD14(+) monocytes in humans.
Origin and functions of tissue macrophages.
Review
Impact
Randolph et al., Saint Louis, United States. In Immunity, 2014
Classical Ly6c(hi) monocytes patrol the extravascular space in resting organs, and Ly6c(lo) nonclassical monocytes patrol the vasculature.
Differential expression of Ly6C and T-bet distinguish effector and memory Th1 CD4(+) cell properties during viral infection.
Impact
GeneRIF
Kaech et al., New Haven, United States. In Immunity, 2011
decreased Ly6C and T-bet (Tbx21) expression distinguished a subset of Th1 cells that displayed greater longevity and proliferative responses to secondary infection
TNF-alpha-dependent regulation of acute pancreatitis severity by Ly-6C(hi) monocytes in mice.
GeneRIF
Steer et al., Boston, United States. In J Biol Chem, 2011
TNF-alpha-dependent regulation of acute pancreatitis severity by Ly-6C(hi) monocytes in mice.
Ly6C supports preferential homing of central memory CD8+ T cells into lymph nodes.
GeneRIF
Jalkanen et al., Turku, Finland. In Eur J Immunol, 2011
in vitro and in vivo differentiation of naive CD8(+) T cells into central (Tcm) but not effector (Tem) memory T cells enhances Ly6C expression, and its crosslinking induces strong LFA-1 clustering on Tcm
Accelerated dendritic cell differentiation from migrating Ly6C(lo) bone marrow monocytes in early dermal West Nile virus infection.
GeneRIF
King et al., Sydney, Australia. In J Immunol, 2011
Ly6C(high-expressing) and Ly6C(low-expressing) bone marrow (BM)-derived monocytes have different fates, demonstrating that BM may be a reservoir of preinflammatory monocytes for rapid deployment as inflammatory dendritic cells during virus infection.
Different tumor microenvironments contain functionally distinct subsets of macrophages derived from Ly6C(high) monocytes.
GeneRIF
Van Ginderachter et al., Brussels, Belgium. In Cancer Res, 2010
The tumor-monocyte pool almost exclusively consisted of Ly6C(hi)CX(3)CR1(low) monocytes, which continuously seeded tumors and renewed all nonproliferating tumor associated macrophages subsets.
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