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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase

Lun, Topors, FOXF2
This gene encodes a nuclear protein which is serine and arginine rich, and contains a RING-type zinc finger domain. It is highly expressed in the testis, and functions as an ubiquitin-protein E3 ligase. Mutations in this gene are associated with retinitis pigmentosa type 31. Alternatively spliced transcript variants, encoding different isoforms, have been observed for this locus. [provided by RefSeq, Sep 2010] (from NCBI)
Top mentioned proteins: Ubiquitin, p53, CAN, HAD, Foxf1
Papers on Lun
Loss of FOXF2 Expression Predicts Poor Prognosis in Hepatocellular Carcinoma Patients.
Yang et al., Shanghai, China. In Ann Surg Oncol, Jan 2016
BACKGROUND: FOXF2 is a member of the forkhead box (FOX) family of transcription factors.
A Shh-Foxf-Fgf18-Shh Molecular Circuit Regulating Palate Development.
Jiang et al., Cincinnati, United States. In Plos Genet, Jan 2016
Previous studies have shown that Shh signaling plays critical roles in palate development and regulates expression of several members of the forkhead-box (Fox) family transcription factors, including Foxf1 and Foxf2, in the facial primordia.
Genotype and Phenotype Studies in Autosomal Dominant Retinitis Pigmentosa (adRP) of the French Canadian Founder Population.
Koenekoop et al., Montréal, Canada. In Invest Ophthalmol Vis Sci, Jan 2016
Eleven (46%) of these mutations were in RHO, four mutations (17%) were found in SNRNP200, three mutations (12.5%) in PRPH2/RDS, three mutations (12.5%) in TOPORS, two mutations (8%) in PRPF31, and one mutation (4%) in IMPDH1.
Metformin and soybean-derived bioactive molecules attenuate the expansion of stem cell-like epithelial subpopulation and confer apoptotic sensitivity in human colon cancer cells.
Simmen et al., Little Rock, United States. In Genes Nutr, Nov 2015
Effects of MET (60 μM) and soybean components genistein (Gen, 2 μM), lunasin (Lun, 2 μM), β-conglycinin (β-con, 3 μM), and glycinin (Gly, 3 μM) on HCT116 cell proliferation, apoptosis, and mRNA/protein expression and on the frequency of the CSC CD133(+)CD44(+) subpopulation by colonosphere assay and fluorescence-activated cell sorting/flow cytometry were evaluated.
FOXF2 suppresses the FOXC2-mediated epithelial-mesenchymal transition and multidrug resistance of basal-like breast cancer.
Feng et al., Tianjin, China. In Cancer Lett, Nov 2015
Our previous study demonstrated that FOXF2 functions as an EMT suppressor and that FOXF2 deficiency promotes BLBC metastasis.
Novel evidence of association with nonsyndromic cleft lip with or without cleft palate was shown for single nucleotide polymorphisms in FOXF2 gene in an Asian population.
Beaty et al., Qingdao, China. In Birth Defects Res A Clin Mol Teratol, Oct 2015
BACKGROUND: The forkhead box F2 gene (FOXF2) located in chromosome 6p25.3
Transcriptional analysis of human cranial compartments with different embryonic origins.
Cunningham et al., Seattle, United States. In Arch Oral Biol, Sep 2015
TFAP2A, TFAP2B, ICAM1, SULF1, TNC and FOXF2 were among differentially expressed genes.
DNA Methylation Affects the SP1-regulated Transcription of FOXF2 in Breast Cancer Cells.
Feng et al., Tianjin, China. In J Biol Chem, Aug 2015
FOXF2 (forkhead box F2) is a mesenchyme-specific transcription factor that plays a critical role in tissue homeostasis through the maintenance of epithelial polarity.
Foxf2 Is Required for Brain Pericyte Differentiation and Development and Maintenance of the Blood-Brain Barrier.
Carlsson et al., Göteborg, Sweden. In Dev Cell, Aug 2015
We show that the forkhead transcription factor Foxf2 is specifically expressed in pericytes of the brain and that Foxf2(-/-) embryos develop intracranial hemorrhage, perivascular edema, thinning of the vascular basal lamina, an increase of luminal endothelial caveolae, and a leaky BBB.
Decreased mRNA expression of transcription factor forkhead box F2 is an indicator of poor prognosis in patients with resected esophageal squamous cell carcinoma.
Fu et al., Guangzhou, China. In Mol Clin Oncol, May 2015
UNASSIGNED: The transcription factor forkhead box F2 (FOXF2) is an evolutionarily conserved DNA-binding protein involved in embryogenesis and metabolism.
FOXF2 deficiency promotes epithelial-mesenchymal transition and metastasis of basal-like breast cancer.
Feng et al., In Breast Cancer Res, 2014
INTRODUCTION: Our previous clinical study demonstrated that the under-expression of FOXF2 is associated with early-onset metastasis and poor prognosis of patients with triple-negative breast cancer.
Prior infection with Type A Francisella tularensis antagonizes the pulmonary transcriptional response to an aerosolized Toll-like receptor 4 agonist.
Ozinsky et al., Seattle, United States. In Bmc Genomics, 2014
Analysis of the promotors of LPS-responsive genes that were perturbed by Type A Francisella infection identified candidate transcription factors that were potentially modulated by the bacteria, including multiple members of the forkhead transcription factor family (FoxA1, Foxa2, FoxD1, Foxd3, Foxf2, FoxI1, Fox03, Foxq1), IRF1, CEBPA, and Mef2.
MicroRNA-519a promotes proliferation and inhibits apoptosis of hepatocellular carcinoma cells by targeting FOXF2.
Xu et al., Wuhan, China. In Febs Open Bio, 2014
Thus, Forkhead box F2 (FOXF2) was identified as a downstream target of miR-519a in HCC.
Disturbed flow: p53 SUMOylation in the turnover of endothelial cells.
Jo et al., Atlanta, United States. In J Cell Biol, 2011
Disturbed flow induces peroxynitrite production and binding to the E3 SUMO (small ubiquitin-like modifier) ligase PIASy (protein inhibitor of activated STATy).
TOPORS, implicated in retinal degeneration, is a cilia-centrosomal protein.
Bhattacharya et al., London, United Kingdom. In Hum Mol Genet, 2011
In photoreceptors, TOPORS localizes primarily to the basal bodies of connecting cilium and in the centrosomes.
Foxf2: a novel locus for anterior segment dysgenesis adjacent to the Foxc1 gene.
Denny et al., Oxford, United Kingdom. In Plos One, 2010
These data provide evidence that the Foxf2 gene, separated from Foxc1 by less than 70 kb of genomic sequence (250 kb in human DNA), may explain human abnormalities in some cases of ASD where FOXC1 has been excluded genetically.
Overexpression of Foxf2 in adipose tissue is associated with lower levels of IRS1 and decreased glucose uptake in vivo.
Enerbäck et al., Göteborg, Sweden. In Am J Physiol Endocrinol Metab, 2010
findings argue that Foxf2 is a previously unrecognized regulator of cellular and systemic whole body glucose tolerance, at least in part, due to lower levels of IRS1.
Deficiency of the dual ubiquitin/SUMO ligase Topors results in genetic instability and an increased rate of malignancy in mice.
Rubin et al., New Brunswick, United States. In Bmc Mol Biol, 2009
These results indicate a unique role for Topors in the maintenance of genomic stability and pericentric heterochromatin, as well as in cellular sensitivity to histone deacetylase inhibitors.
Human FOX gene family (Review).
Katoh et al., Japan. In Int J Oncol, 2004
Human Forkhead-box (FOX) gene family consists of at least 43 members, including FOXA1, FOXA2, FOXA3, FOXB1, FOXC1, FOXC2, FOXD1, FOXD2, FOXD3, FOXD4, FOXD5 (FOXD4L1), FOXD6 (FOXD4L3), FOXE1, FOXE2, FOXE3, FOXF1, FOXF2, FOXG1 (FOXG1B), FOXH1, FOXI1, FOXJ1, FOXJ2, FOXJ3, FOXK1, FOXK2, FOXL1, FOXL2, FOXM1, FOXN1, FOXN2 (HTLF), FOXN3 (CHES1), FOXN4, FOXN5 (FOXR1), FOXN6 (FOXR2), FOXO1 (FOXO1A), FOXO2 (FOXO6), FOXO3 (FOXO3A), FOXO4 (MLLT7), FOXP1, FOXP2, FOXP3, FOXP4, and FOXQ1.
Wei Lun Visiting Professorial Lecture: Nitric oxide in the regulation of vascular function: an historical overview.
Ignarro, Los Angeles, United States. In J Card Surg, 2002
The field of nitric oxide (NO) research has developed in explosive proportions since the discovery of endogenous NO in 1986.
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