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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Lumican

Lum, Lumican
This gene encodes a member of the small leucine-rich proteoglycan (SLRP) family that includes decorin, biglycan, fibromodulin, keratocan, epiphycan, and osteoglycin. In these bifunctional molecules, the protein moiety binds collagen fibrils and the highly charged hydrophilic glycosaminoglycans regulate interfibrillar spacings. Lumican is the major keratan sulfate proteoglycan of the cornea but is also distributed in interstitial collagenous matrices throughout the body. Lumican may regulate collagen fibril organization and circumferential growth, corneal transparency, and epithelial cell migration and tissue repair. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, HAD, POLYMERASE, ACID, AGE
Papers on Lum
A self-consistent phase-field approach to implicit solvation of charged molecules with Poisson-Boltzmann electrostatics.
New
McCammon et al., San Diego, United States. In J Chem Phys, Jan 2016
Our theory is developed based on rigorous mathematical studies and is also connected to the Lum-Chandler-Weeks theory (1999).
A 6 gene signature identifies the risk of developing cirrhosis in patients with chronic hepatitis B.
New
Lu et al., Shanghai, China. In Front Biosci, Dec 2015
Secondly a signature consisting of 6 PGs (CD24, CXCL6, EHF, ITGBL1, LUM and SOX9) most predictive for cirrhosis risk in CHB patients was developed in the selection set (n=40) by use of PAM and PCR approach.
A fast and sensitive method for quantifying lumefantrine and desbutyl-lumefantrine using LC-MS/MS.
New
Pohanka et al., Huddinge, Sweden. In J Chromatogr B Analyt Technol Biomed Life Sci, Dec 2015
A sensitive liquid chromatography tandem mass spectrometry (LC-MS/MS) method was developed for quantification of lumefantrine (LUM) and its metabolite desbutyl-lumefantrine (DBL) in human plasma.
Host Protein Biomarkers Identify Active Tuberculosis in HIV Uninfected and Co-infected Individuals.
New
Paramithiotis et al., United States. In Ebiomedicine, Sep 2015
Biomarker panels whose composition differed according to HIV status, and consisted of 8 host proteins in HIV(-) individuals (CD14, SEPP1, SELL, TNXB, LUM, PEPD, QSOX1, COMP, APOC1), or 10 host proteins in HIV(+) individuals (CD14, SEPP1, PGLYRP2, PFN1, VASN, CPN2, TAGLN2, IGFBP6), respectively, distinguished TB from ORD with excellent accuracy (AUC = 0.96 for HIV(-) TB, 0.95 for HIV(+) TB).
Lumican deficiency results in cardiomyocyte hypertrophy with altered collagen assembly.
New
Kern et al., Charleston, United States. In J Mol Cell Cardiol, Jul 2015
We hypothesized that the small leucine-rich proteoglycan (SLRP) lumican (LUM), which binds collagen and facilitates collagen assembly in other tissues, may play a critical role in establishing the postnatal murine myocardial ECM.
[Characteristics of refractive status of mutant Lumican transgenic mice].
New
Liu et al., Beijing, China. In Zhonghua Yan Ke Za Zhi, Jul 2015
OBJECTIVE: To investigate the change of refractive status in transgenic mice with mutant Lumican (bright proteoglycan) gene at different ages.
[Effect of Electroacupuncture stimulation of acupoints of the Pericardium Meridian on serum NGF and Nogo-A contents and cerebral NGF and Nogo-A expression in cerebral ischemia rats].
New
Wu et al., In Zhen Ci Yan Jiu, Apr 2015
METHODS: A total of 50 SD rats were equally randomized into normal control, sham, model, EA-Pericardium-Meridian acupoints (EA-PCM) and EA-Lung-Meridian acupoint (EA-LUM) groups.
Constitutive expression of AhR and BRCA-1 promoter CpG hypermethylation as biomarkers of ERα-negative breast tumorigenesis.
Selmin et al., Tucson, United States. In Bmc Cancer, 2014
Finally, we examined the association between expression of AhR and BRCA-1 promoter CpG methylation in human triple-negative (TNBC), luminal-A (LUM-A), LUM-B, and epidermal growth factor receptor-2 (HER-2)-positive breast tumor samples.
Microenvironmental Modulation of Decorin and Lumican in Temozolomide-Resistant Glioblastoma and Neuroblastoma Cancer Stem-Like Cells.
Prados et al., Sassari, Italy. In Plos One, 2014
The aim of this study was to determine whether the SLRPs decorin (DCN) and lumican (LUM) are recruited in cell plasticity and microenvironmental adaptation of differentiated cancer cells induced towards stem-like phenotype.
Autophagy is decreased in triple-negative breast carcinoma involving likely the MUC1-EGFR-NEU1 signalling pathway.
Bensussan et al., Reims, France. In Int J Clin Exp Pathol, 2014
In the aim to understand the relationship between EGFR-MUC1-NEU1 complex and autophagy in breast carcinoma, we compared triple negative (TN) showing a high-EGFR expression with luminal (LUM) presenting low-EGFR level.
Lack of association between LUM rs3759223 polymorphism and high myopia.
Review
Li et al., China. In Optom Vis Sci, 2014
PURPOSE: Previous evidence has indicated that the lumican (LUM) gene is a candidate susceptibility gene of high myopia; however, the association between LUM promoter regions rs3759223 polymorphism and high myopia remains controversial and ambiguous.
The role of extracellular matrix in corneal wound healing.
Review
Saika et al., Wakayama, Japan. In Cornea, 2013
This review will focus on the biological functions of several ECM components, such as osteopontin (OPN), tenascin (TCN), and lumican (Lum).
Ten SNPs of PAX6, Lumican, and MYOC genes are not associated with high myopia in Han Chinese.
GeneRIF
Fu et al., Harbin, China. In Ophthalmic Genet, 2012
Our results confirm that the PAX6, Lumican, and MYOC genes were not associated with high myopia in the Han Chinese in Northeastern China.
Association analysis of polymorphisms in lumican gene and systemic lupus erythematosus in a Taiwan Chinese Han population.
GeneRIF
Tsai et al., Taiwan. In J Rheumatol, 2011
Single nucleotide polymorphisms in lumican gene are associated with systemic lupus erythematosus in the Taiwan Chinese Han population.
Lumican regulates osteosarcoma cell adhesion by modulating TGFβ2 activity.
GeneRIF
Tzanakakis et al., Irákleion, Greece. In Int J Biochem Cell Biol, 2011
regulates osteosarcoma cell adhesion by modulating TGFbeta2 activity
Expression of lumican and fibromodulin following interleukin-1 beta stimulation of disc cells of the human temporomandibular joint.
GeneRIF
Fujita et al., Wakayama, Japan. In Eur J Histochem, 2010
lumican and fibromodulin display different behaviors and that lumican may promote regeneration of the TMJ after degeneration and deformation induced by IL-1 beta.
Quantitative proteomics analysis by isobaric tags for relative and absolute quantitation identified Lumican as a potential marker for acute aortic dissection.
GeneRIF
Rao et al., Shanghai, China. In J Biomed Biotechnol, 2010
Lumican may be a potential acute aortic dissection (AAD)-related serum marker that may assist the diagnosis of AAD.
Functions of lumican and fibromodulin: lessons from knockout mice.
Review
Chakravarti, Baltimore, United States. In Glycoconj J, 2002
The phenotypes of lumican-null (Lum(-/-)), Fibromodulin-null (Fmod(-/-)) and compound double-null (Lum(-/-)Fmod(-/-)) mice identify a broad range of tissues where these two proteoglycans have overlapping and unique roles in modulating the extracellular matrix and cellular behavior.
Corneal cell proteins and ocular surface pathology.
Review
Hazlett et al., Detroit, United States. In Biotech Histochem, 1999
Lumican, keratocan and mimecan are the major keratan sulfate proteoglycans of the corneal stroma.
Phase I trial of etoposide with cyclosporine as a modulator of multidrug resistance.
Impact
Sikic et al., Palo Alto, United States. In J Clin Oncol, 1992
When used with high-dose CsA, etoposide doses should be reduced by approximately 50% to compensate for the pharmacokinetic effects of CsA on etoposide (Lum et al, J Clin Oncol, 10:1635-1642, 1992).
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