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Leukocyte tyrosine kinase

Ltk, leukocyte tyrosine kinase
The protein encoded by this gene is a member of the ros/insulin receptor family of tyrosine kinases. Tyrosine-specific phosphorylation of proteins is a key to the control of diverse pathways leading to cell growth and differentiation. Four alternatively spliced transcript variants encoding different isoforms have been described for this gene. These transcripts are expressed in a tissue-specific manner in lymphocytes, brain and neuroblastoma cells, and the encoded isoforms exhibit different subcellular localization. The lymphocyte and brain specific variants initiate translation at non-AUG (CUG) start codons. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, ACID, HAD, POLYMERASE, V1a
Papers on Ltk
Augmentor α and β (FAM150) are ligands of the receptor tyrosine kinases ALK and LTK: Hierarchy and specificity of ligand-receptor interactions.
New
Schlessinger et al., New Haven, United States. In Proc Natl Acad Sci U S A, Jan 2016
Detailed binding experiments using cells expressing ALK or the related receptor leukocyte tyrosine kinase (LTK) demonstrate that AUG-α binds and robustly activates both ALK and LTK.
Deorphanization of the human leukocyte tyrosine kinase (LTK) receptor by a signaling screen of the extracellular proteome.
Williams et al., San Francisco, United States. In Proc Natl Acad Sci U S A, 2014
Taking this approach, we have screened a large collection (3,191 proteins) of extracellular proteins for their ability to activate signaling of an orphan receptor, leukocyte tyrosine kinase (LTK).
Anaplastic lymphoma kinase (ALK): structure, oncogenic activation, and pharmacological inhibition.
Review
Roskoski, United States. In Pharmacol Res, 2013
ALK is a member of the insulin receptor superfamily and is most closely related to leukocyte tyrosine kinase (Ltk), which is a receptor protein-tyrosine kinase.
A simple, highly visual in vivo screen for anaplastic lymphoma kinase inhibitors.
Kelsh et al., Bath, United Kingdom. In Acs Chem Biol, 2013
We note that TAE684 also inhibits the closely related leukocyte tyrosine kinase (Ltk) that is required for endogenous iridophore development.
Quantitative single-cell ion-channel gene expression profiling through an improved qRT-PCR technique combined with whole cell patch clamp.
Snyders et al., Antwerp, Belgium. In J Neurosci Methods, 2012
The technique was validated on a stable Ltk(-) cell line expressing the Kv2.1 channel and on embryonic dorsal root ganglion (DRG) cells probing for the expression of Kv2.1.
Anaplastic lymphoma kinase and leukocyte tyrosine kinase: functions and genetic interactions in learning, memory and adult neurogenesis.
GeneRIF
Raber et al., Portland, United States. In Pharmacol Biochem Behav, 2012
In hippocampus, Ltk and Alk (anaplastic lymphoma kinase) are expressed throughout dentate gyrus, CA1, and CA3. Data suggest genetic interactions between Ltk and Alk in neurogenesis and behavioral measures (i.e., activity, anxiety, spatial memory).
ALK-activating homologous mutations in LTK induce cellular transformation.
GeneRIF
Reuther et al., Tampa, United States. In Plos One, 2011
aberrant activation of LTK may contribute to neoplastic cell growth.
ALK receptor activation, ligands and therapeutic targeting in glioblastoma and in other cancers.
Wellstein, Washington, D.C., United States. In Front Oncol, 2011
An analysis of 18 published gene expression data sets from different cancers shows that overexpression of ALK, its smaller homolog LTK (leukocyte tyrosine kinase) and the ligands PTN and MK in cancer tissues from patients correlate significantly with worse course and outcome of the disease.
Leukocyte antigen-related protein tyrosine phosphatase negatively regulates hydrogen peroxide-induced vascular smooth muscle cell apoptosis.
GeneRIF
Madamanchi et al., Chapel Hill, United States. In J Biol Chem, 2009
LAR regulates Fyn/JAK2/STAT3 and Fyn/p38 MAPK pathways involved in ROS-induced apoptosis
Gain-of-function polymorphism in mouse and human Ltk: implications for the pathogenesis of systemic lupus erythematosus.
GeneRIF
Hirose et al., Tokyo, Japan. In Hum Mol Genet, 2004
polymorphic LTKs cause up-regulation of the PI3K pathway and possibly form one genetic component of susceptibility to abnormal proliferation of self-reactive B cells in systemic lupus erythematosus
Receptor heteromerization in adenosine A2A receptor signaling: relevance for striatal function and Parkinson's disease.
Review
Ferré et al., Stockholm, Sweden. In Neurology, 2004
Recently evidence has been presented that adenosine A2A and dopamine D2 receptors form functional heteromeric receptor complexes as demonstrated in human neuroblastoma cells and mouse fibroblast Ltk- cells.
Jeb signals through the Alk receptor tyrosine kinase to drive visceral muscle fusion.
Impact
Palmer et al., Umeå, Sweden. In Nature, 2003
The Drosophila melanogaster gene Anaplastic lymphoma kinase (Alk) is homologous to mammalian Alk, a member of the Alk/Ltk family of receptor tyrosine kinases (RTKs).
Microcapsules as bio-organs for somatic gene therapy.
Review
Chang, Hamilton, Canada. In Ann N Y Acad Sci, 1998
After intraperitoneal implantation, genetically modified mouse Ltk- fibroblasts or C2C12 myoblasts encapsulated in alginate-poly-L-lysine-alginate could deliver recombinant gene products (human growth hormone, human factor IX) to the systemic circulation of mice.
Effects of lisinopril on cardiac contractility and ionic currents.
Review
Tamargo et al., Madrid, Spain. In Gen Pharmacol, 1994
expressed in a mouse L cell line (Ltk-).
The ltk receptor tyrosine kinase is expressed in pre-B lymphocytes and cerebral neurons and uses a non-AUG translational initiator.
GeneRIF
de la Monte et al., Boston, United States. In Embo J, 1990
Translation initiates from a non-AUG codon (CUG) in some Ltk transcript variants.
Properties of human interleukin-2 receptors expressed on non-lymphoid cells by cDNA transfection.
Review
Noma et al., In Mol Biol Med, 1984
We have established non-lymphoid cell lines HeLa, Ltk and NIH3T3 expressing the human interleukin-2 (IL-2) receptor by transfection of human IL-2 receptor complementary DNA.
Gene transfer, expression, and molecular cloning of the human transferrin receptor gene.
Impact
Ruddle et al., In Cell, 1984
Mouse Ltk- cells were cotransformed with the herpes simplex thymidine kinase gene and total human DNA.
Expression of human cardiac actin in mouse L cells: a sarcomeric actin associates with a nonmuscle cytoskeleton.
Impact
Skoultchi et al., In Cell, 1984
A cloned human cardiac actin gene, introduced into mouse Ltk- cells, is expressed in several thymidine kinase (tk)-positive cotransfectants.
Correlation of glucocorticoid receptor binding sites on MMTV proviral DNA with hormone inducible transcription.
Impact
Hynes et al., In Science, 1984
This construction allowed the tk gene to be expressed in a hormone-responsive fashion upon transfection into Ltk- cells.
Regulation of alpha genes of herpes simplex virus: expression of chimeric genes produced by fusion of thymidine kinase with alpha gene promoters.
Impact
Roizman et al., In Cell, 1981
The resultant recombinant DNA was inserted into the viral genome and was also used to convert Ltk- cells to tk+ phenotype.
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