Dual Roles of RNF2 in Melanoma Progression.
Houston, United States. In Cancer Discov, Dec 2015
Mechanistically, RNF2-mediated invasive behavior is dependent on its ability to monoubiquitinate H2AK119 at the promoter of LTBP2, resulting in silencing of this negative regulator of TGFβ signaling.
Latent TGF-β-binding proteins.
New York City, United States. In Matrix Biol, Sep 2015
LTBP-3 appears to have a role in skeletal formation including tooth development.
Genetics of primary glaucoma.
Riyadh, Saudi Arabia. In Curr Opin Ophthalmol, 2011
In 2009, patients diagnosed with congenital/infantile glaucoma were found to have recessive mutations in a second gene, LTBP2, with a phenotypic spectrum that includes primary megalocornea, spherophakia with ectopia lentis, and lens-related glaucoma.