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Latent transforming growth factor beta binding protein 3

LTBP-2, LTBP-3, latent transforming growth factor beta binding protein 2
The protein encoded by this gene forms a complex with transforming growth factor beta (TGF-beta) proteins and may be involved in their subcellular localization. Activation of this complex requires removal of the encoded binding protein. This protein also may play a structural role in the extracellular matrix. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2010] (from NCBI)
Top mentioned proteins: TGF-beta, fibrillin-1, LTBP-1, CAN, HAD
Papers on LTBP-2
Co-localization of LTBP-2 with FGF-2 in fibrotic human keloid and hypertrophic scar.
New
Gibson et al., Adelaide, Australia. In J Mol Histol, Feb 2016
We have recently shown that Latent transforming growth factor-beta-1 binding protein-2 (LTBP-2) has a single high-affinity binding site for fibroblast growth factor-2 (FGF-2) and that LTBP-2 blocks FGF-2 induced cell proliferation.
Downregulation of lncRNA-MALAT1 Affects Proliferation and the Expression of Stemness Markers in Glioma Stem Cell Line SHG139S.
New
Du et al., Suzhou, China. In Cell Mol Neurobiol, Jan 2016
Previous research has showed that MALAT1 can activate LTBP3 gene in mesenchymal stem cells.
Detection of Novel Genomic Markers for Predicting Prognosis in Hepatocellular Carcinoma Patients by Integrative Analysis of Copy Number Aberrations and Gene Expression Profiles: Results from a Long-Term Follow-Up.
New
Cheong et al., Suwŏn, South Korea. In Dna Cell Biol, Jan 2016
Integrative analysis revealed that the overexpression of 16 genes, including FGR (p = 0.003), RELA (p = 0.049), LTBP3 (p = 0.050), and RIN1 (p = 0.023), was significantly associated with shorter time to tumor recurrence.
Dual Roles of RNF2 in Melanoma Progression.
New
Chin et al., Houston, United States. In Cancer Discov, Dec 2015
Mechanistically, RNF2-mediated invasive behavior is dependent on its ability to monoubiquitinate H2AK119 at the promoter of LTBP2, resulting in silencing of this negative regulator of TGFβ signaling.
Genetic analysis of the contribution of LTBP-3 to thoracic aneurysm in Marfan syndrome.
New
Rifkin et al., New York City, United States. In Proc Natl Acad Sci U S A, Dec 2015
We previously reported the absence of LTBP-3 in matrices lacking fibrillin-1, suggesting that perturbed TGFβ signaling in MFS might be due to defective interaction of latent TGFβ complexes containing LTBP-3 with mutant fibrillin-1 microfibrils.
CYP1B1 and MYOC Mutations in Vietnamese Primary Congenital Glaucoma Patients.
New
Vithana et al., Singapore, Singapore. In J Glaucoma, Dec 2015
The 3 implicated genes are cytochrome P450 family I subfamily B polypeptide 1 (CYP1B1), latent transforming growth factor β-binding protein 2 (LTBP2), and myocilin (MYOC).
Latent TGF-β-binding proteins.
Review
New
Rifkin et al., New York City, United States. In Matrix Biol, Sep 2015
LTBP-3 appears to have a role in skeletal formation including tooth development.
A Possible Role for LTBP2 in the Etiology of Primary Angle Closure Glaucoma.
New
Elahi et al., Tehrān, Iran. In J Ophthalmic Vis Res, Apr 2015
PURPOSE: To assess the association of LTBP2 mutations with primary angle closure glaucoma (PACG).
Glaucoma in iran and contributions of studies in iran to the understanding of the etiology of glaucoma.
Review
Elahi et al., Tehrān, Iran. In J Ophthalmic Vis Res, 2015
Further genetic analysis of Iranian PCG patients led to identification of Latent-transforming growth factor beta-binding protein 2 (LTBP2) as a causative gene for both PCG and several diseases which are often accompanied by glaucomatous presentations, such as Weill-Marchesani syndrome 3 (WMS3).
LTBP-2 Has a Single High-Affinity Binding Site for FGF-2 and Blocks FGF-2-Induced Cell Proliferation.
Gibson et al., Adelaide, Australia. In Plos One, 2014
Latent transforming growth factor-beta-1 binding protein-2 (LTBP-2) belongs to the fibrillin-LTBP superfamily of extracellular matrix proteins.
Targeted deep DNA methylation analysis of circulating cell-free DNA in plasma using massively parallel semiconductor sequencing.
Holmila et al., Lyon, France. In Epigenomics, 2014
MATERIALS & METHODS: Methylation of VIM, FBLN1, LTBP2, HINT2, h19 and IGF2 was analyzed in plasma cfDNA and white blood cell DNA obtained from eight hepatocellular carcinoma patients and eight controls using Ion Torrent™ PGM sequencer.
LTPB2 acts as a prognostic factor and promotes progression of cervical adenocarcinoma.
Xu et al., Shanghai, China. In Am J Transl Res, 2014
Latent transforming growth factor-beta-1 binding protein-2 (LTBP-2) is a member of the fibrillin/LTBP super family of extracellular matrix proteins, found to be overexpressed in certain malignant tumors.
The microfibril hypothesis of glaucoma: implications for treatment of elevated intraocular pressure.
Review
Kuchtey et al., Nashville, United States. In J Ocul Pharmacol Ther, 2014
A role for microfibrils in glaucoma is suggested by identification of risk alleles in LOXL1 for exfoliation glaucoma and mutations in LTBP2 for primary congenital glaucoma, both of which are microfibril-associated genes.
The novel marker LTBP2 predicts all-cause and pulmonary death in patients with acute dyspnoea.
GeneRIF
Mueller et al., Basel, Switzerland. In Clin Sci (lond), 2012
plasma levels of LTBP2 present a novel and powerful predictor of all-cause mortality, and particularly pulmonary death
Susceptible gene single nucleotide polymorphism and hemorrhage risk in patients with brain arteriovenous malformation.
GeneRIF
Huang et al., Guangzhou, China. In J Clin Neurosci, 2011
This study provided evidence that the IL-17A-197 G/A and TGFR-beta2-875 A/G genotype is closely related to hemorrhage risk for patients with brain arteriovenous malformation.
Genetics of primary glaucoma.
Review
Khan, Riyadh, Saudi Arabia. In Curr Opin Ophthalmol, 2011
In 2009, patients diagnosed with congenital/infantile glaucoma were found to have recessive mutations in a second gene, LTBP2, with a phenotypic spectrum that includes primary megalocornea, spherophakia with ectopia lentis, and lens-related glaucoma.
Latent transforming growth factor beta-binding proteins-2 and -3 inhibit the proprotein convertase 5/6A.
GeneRIF
Seidah et al., Montréal, Canada. In J Biol Chem, 2011
Latent transforming growth factor beta-binding proteins-2 and -3 inhibit the proprotein convertase 5/6A.
A proteomic approach for identification and localization of the pericellular components of chondrocytes.
GeneRIF
Moed et al., Saint Louis, United States. In Histochem Cell Biol, 2011
A proteomic approach for identification and localization of the pericellular components of chondrocytes
[Development of the iridocorneal angle and congenital glaucoma].
Review
Tamm, Regensburg, Germany. In Ophthalmologe, 2011
More rarely, mutations in latent transforming growth factor beta binding protein 2 (LTBP2) or in the transcription factor FOXC1 have been described as causative for primary congenital glaucoma.
Congenital megalocornea with zonular weakness and childhood lens-related secondary glaucoma - a distinct phenotype caused by recessive LTBP2 mutations.
GeneRIF
Alkuraya et al., Riyadh, Saudi Arabia. In Mol Vis, 2010
Novel homozygous mutations in the LTBP-2 gene segregated with the phenotype in each affected consanguineous family cause congenital megalocornea with zonular weakness and childhood lens-related secondary glaucoma.
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