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Latent transforming growth factor beta binding protein 1

LTBP-1, latent transforming growth factor-beta binding protein-1
The protein encoded by this gene belongs to the family of latent TGF-beta binding proteins (LTBPs). The secretion and activation of TGF-betas is regulated by their association with latency-associated proteins and with latent TGF-beta binding proteins. The product of this gene targets latent complexes of transforming growth factor beta to the extracellular matrix, where the latent cytokine is subsequently activated by several different mechanisms. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: TGF-beta, fibrillin-1, LTBP-2, LAP, CAN
Papers on LTBP-1
Identification of key genes associated with the effect of estrogen on ovarian cancer using microarray analysis.
Zhang et al., Changchun, China. In Arch Gynecol Obstet, Feb 2016
Functional enrichment analysis of DEGs indicated that ACVR2B, LTBP1, BMP7 and MYC involved in TGF-beta signaling pathway.
Latent transforming growth factor-β binding proteins (LTBP-1 and LTBP-2) and gingiva keratinization.
Yuan et al., Tainan City, Taiwan. In Oral Dis, Sep 2015
However, whether LTBP-1 and LTBP-2 play roles in gingiva keratinization remains unclear.
Latent TGF-β-binding proteins.
Rifkin et al., New York City, United States. In Matrix Biol, Sep 2015
There are four LTBPs isoforms in the human genome (LTBP-1, -2, -3, and -4), all of which appear to associate with fibrillin and the biology of each isoform is reviewed here.
Adamtsl2 deletion results in bronchial fibrillin microfibril accumulation and bronchial epithelial dysplasia--a novel mouse model providing insights into geleophysic dysplasia.
Apte et al., Cleveland, United States. In Dis Model Mech, May 2015
ADAMTSL2 has been previously shown to bind FBN1 and latent TGFβ-binding protein-1 (LTBP1).
Abrogation of both short and long forms of latent transforming growth factor-β binding protein-1 causes defective cardiovascular development and is perinatally lethal.
Rifkin et al., New York City, United States. In Matrix Biol, Apr 2015
Here, we describe a third line of Ltbp1 knockout mice generated utilizing a conditional knockout strategy that ablated expression of both L and S forms of LTBP-1.
Marek's disease virus-encoded analog of microRNA-155 activates the oncogene c-Myc by targeting LTBP1 and suppressing the TGF-β signaling pathway.
Luo et al., Changchun, China. In Virology, Feb 2015
We have presently identified the host mRNA targets of mdv1-miR-M4-5 and identified the latent TGF-β binding protein 1 (LTBP1) as a critical target for it.
DNA methylation Landscape of body size variation in sheep.
Du et al., Beijing, China. In Sci Rep, 2014
We tested three regions in LTBP1, and DNA methylation of two CpG sites showed significant correlation with its RNA expression.
Cerebral small vessel disease-related protease HtrA1 processes latent TGF-β binding protein 1 and facilitates TGF-β signaling.
Dichgans et al., München, Germany. In Proc Natl Acad Sci U S A, 2014
We identify latent TGF-β binding protein 1 (LTBP-1), an extracellular matrix protein and key regulator of TGF-β bioavailability, as a novel HtrA1 target.
Transforming growth factor beta 1 activation, storage, and signaling pathways in idiopathic pulmonary fibrosis in dogs.
Clercx et al., Liège, Belgium. In J Vet Intern Med, 2014
no difference was seen for Smad7, LTBP1 and 2. Serum TGF-β1 concentration was higher in predisposed compared with nonpredisposed breeds (P < .0001).
Sequestration of latent TGF-β binding protein 1 into CADASIL-related Notch3-ECD deposits.
Haffner et al., In Acta Neuropathol Commun, 2013
Based on recent evidence indicating a role for the transforming growth factor-β (TGF-β) pathway in sporadic and familial small vessel disease we studied fibronectin, fibrillin-1 and latent TGF-β binding protein 1 (LTBP-1), three ECM constituents involved in the regulation of TGF-β bioavailability, in post-mortem brain tissue from CADASIL patients and control subjects.
Aryl hydrocarbon receptor (AhR) modulates cockroach allergen-induced immune responses through active TGFβ1 release.
Gao et al., Baltimore, United States. In Mediators Inflamm, 2013
The role of latent TGFβ1 binding protein-1 (LTBP1) in mediating TCDD induced active TGFβ1 release was also examined.
The alteration of plasma TGF-β1 levels in patients with brain tumors after tumor removal.
Chio et al., Kao-hsiung, Taiwan. In Kaohsiung J Med Sci, 2012
Data show that plasma TGF-beta1 was elevated in the circulation of patients with brain tumors and that significant decreases in TGF-beta1 levels were observed after the removal of benign and malignant tumors.
Tgf-β1 induces autophagy and promotes apoptosis in renal tubular epithelial cells.
Lin et al., Fuzhou, China. In Int J Mol Med, 2012
Increased generation of reactive oxygen species (ROS) and enhanced expression of NADPH oxidases were found to be associated with the TGF-beta1-induced autophagy.
Involvement of plasminogen activator inhibitor-1 in the pathogenesis of atopic cataracts.
Murakami et al., Tokyo, Japan. In Invest Ophthalmol Vis Sci, 2012
The expression of PAI-1 mRNA and TGF-beta1 mRNA was significantly higher in the cDNA samples obtained from the atopic cataracts than those obtained from the senile cataracts.
Transforming growth factor-β enhances invasion and metastasis in Ras-transfected human malignant epidermal keratinocytes.
Paterson et al., Bristol, United Kingdom. In Int J Exp Pathol, 2012
Elevated expression of either TGF-beta1 or TGF-beta2 in cells that represent the early stages in the development of human squamous cell carcinoma results in a more aggressive phenotype.
Genome-wide association study of copy number variants suggests LTBP1 and FGD4 are important for alcohol drinking.
Deng et al., Shanghai, China. In Plos One, 2011
susceptibility genes associated with alcohol drinking
Genetic and molecular aspects of acromelic dysplasia.
Cormier-Daire et al., Paris, France. In Pediatr Endocrinol Rev, 2009
Using a yeast double hybrid screen, we have identified LTBP1 (Latent TGFbeta Binding protein 1) as a partner of ADAMTSL2.
Fitting a xenobiotic receptor into cell homeostasis: how the dioxin receptor interacts with TGFbeta signaling.
Fernandez-Salguero et al., Badajoz, Spain. In Biochem Pharmacol, 2009
Transforming growth factor beta (TGFbeta) is an extracellular cytokine that regulates such critical cellular responses as proliferation, apoptosis, differentiation, angiogenesis and migration, and it is assumed that the latency-associated protein LTBP-1 plays a relevant role in TGFbeta targeting and activation in the extracellular matrix (ECM).
Multiple transforming growth factor-beta isoforms and receptors function during epithelial-mesenchymal cell transformation in the embryonic heart.
Runyan et al., Tucson, United States. In Cells Tissues Organs, 2006
Latent TGF-beta-binding protein (LTBP-1) and endoglin have a role in the EMT process.
[Pseudoexfoliation syndrome--etiopatogenesis and clinical course].
Kecik et al., Warsaw, Poland. In Klin Oczna, 2005
The prevailing presence of elastic fiber epitopes, mainly elastic microfibrillar components (elastin, vitronectin, amyloid P, fibrillin-1, LTBP-1), has led to the current theory explaining PEX as a type of elastosis, affecting especially elastic microfibrils.
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