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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Leukotriene A4 hydrolase

LTA4, leukotriene A4 hydrolase, LTA4 hydrolase, LTA4H
Top mentioned proteins: ACID, 5-lipoxygenase, CAN, aminopeptidase, FLAP
Papers on LTA4
Deletion of 5-Lipoxygenase in the Tumor Microenvironment Promotes Lung Cancer Progression and Metastasis through Regulating T Cell Recruitment.
New
Nemenoff et al., Aurora, United States. In J Immunol, Feb 2016
Increased tumor progression was partially reproduced in global LTC4 synthase KO or mice transplanted with LTA4 hydrolase-deficient bone marrow.
Dual anti-inflammatory and selective inhibition mechanism of leukotriene A4 hydrolase/aminopeptidase: insights from comparative molecular dynamics and binding free energy analyses.
New
Soliman et al., Durban, South Africa. In J Biomol Struct Dyn, Feb 2016
UNASSIGNED: Human leukotriene A4 hydrolase/aminopeptidase (LTA4H) is a zinc metalloenzyme with a dual catalytic activity; conversion of LTA4 into LTB4 and degradation of chemotactic tripeptide Pro-Gly-Pro (PGP).
Ustekinumab in hidradenitis suppurativa: clinical results and a search for potential biomarkers in serum.
New
Horváth et al., Groningen, Netherlands. In Br J Dermatol, Jan 2016
Good responders had milder disease and lower expression of leukotriene A4-hydrolase (LTA4H).
Characterization of an epoxide hydrolase from the Florida red tide dinoflagellate, Karenia brevis.
New
Rein et al., Miami, United States. In Phytochemistry, Dec 2015
Data mining of K. brevis transcriptome libraries revealed two classes of epoxide hydrolases: microsomal and leukotriene A4 (LTA4) hydrolases.
Antileukotrienes in upper airway inflammatory diseases.
Review
New
Şahin et al., Eskişehir, Turkey. In Curr Allergy Asthma Rep, Nov 2015
Leukotrienes (LTs) are a family of inflammatory mediators including LTA4, LTB4, LTC4, LTD4, and LTE4.
Diverse ways of perturbing the human arachidonic acid metabolic network to control inflammation.
New
Impact
Lai et al., Beijing, China. In Acc Chem Res, Sep 2015
Consequently, simultaneous control of cyclooxygenase-1 and -2 and leukotriene A4 hydrolase, as well as 5-lipoxygenase and prostaglandin E2 synthase were found to be among the best solutions.
[Study on the association between leukotriene A4 hydrolase gene polymorphism and ischemic stroke].
New
Hu et al., Beijing, China. In Zhonghua Liu Xing Bing Xue Za Zhi, Aug 2015
OBJECTIVE: To investigate the association between polymorphism of leukotriene A4 hydrolase (LTA4H) gene among ischemic stroke patients and the related subtypes in the discordant sib pairs.
MMP generated matrikines.
Review
New
Blalock et al., Birmingham, United States. In Matrix Biol, May 2015
In chronic cigarette smoke related lung disease, the PGP pathway can become a self-propagating cycle of inflammation through cigarette-smoke mediated inhibition of leukotriene A4 hydrolase, the enzyme responsible for degrading PGP and halting acute inflammation.
Novel zinc protease gene isolated from Dictyostelium discoideum is structurally related to mammalian leukotriene A4 hydrolase.
Hou et al., Shanghai, China. In Genet Mol Res, 2014
The novel zinc protease gene may function as an LTA4 hydrolase and contribute to the shortening of the allC RNAi mutant cell cycle.
Positioning of aminopeptidase inhibitors in next generation cancer therapy.
Review
Peters et al., Amsterdam, Netherlands. In Amino Acids, 2014
This review focuses on the function and subcellular location of five key aminopeptidases (aminopeptidase N, leucine aminopeptidase, puromycin-sensitive aminopeptidase, leukotriene A4 hydrolase and endoplasmic reticulum aminopeptidase 1/2) and their association with different diseases, in particular cancer and their current position as target for therapeutic intervention by aminopeptidase inhibitors.
Tuberculous meningitis: more questions, still too few answers.
Review
Impact
Schoeman et al., London, United Kingdom. In Lancet Neurol, 2013
Large doses of rifampicin and fluoroquinolones might improve outcome, and the beneficial effect of adjunctive corticosteroids on survival might be augmented by aspirin and could be predicted by screening for a polymorphism in LTA4H, which encodes an enzyme involved in eicosanoid synthesis.
Potential new therapeutic targets for pathological pruritus.
Review
Kuraishi, Toyama, Japan. In Biol Pharm Bull, 2012
Newly identified potential targets for pathological pruritus include receptors (histamine H4 receptor, leukotriene B4 receptors, interleukin-31 receptor A, bombesin BB2 receptor, toll-like receptor 3, α-adrenoceptor, and opioid μ- and κ-receptors), channels (transient receptor potential (TRP) V3 and TRPA1 channels), and enzymes (histidine decarboxylase, sphingomyelin glucosylceramide deacylase, 5-lipoxygenase, leukotriene A4 hydrolase, and autotaxin).
Leukotriene B4-driven neutrophil recruitment to the skin is essential for allergic skin inflammation.
Impact
Geha et al., Boston, United States. In Immunity, 2012
Cotransfer of wild-type (WT) neutrophils, but not neutrophils deficient in BLT1 or the LTB4-synthesizing enzyme LTA4H, restored the ability of WT CD4(+) effector T cells to transfer allergic skin inflammation to Ltb4r1(-/-) recipients.
Host genotype-specific therapies can optimize the inflammatory response to mycobacterial infections.
Impact
Ramakrishnan et al., Seattle, United States. In Cell, 2012
Modulation of the leukotriene A(4) hydrolase (LTA4H) locus, which controls the balance of pro- and anti-inflammatory eicosanoids, reveals two distinct molecular routes to mycobacterial susceptibility converging on dysregulated TNF levels: inadequate inflammation caused by excess lipoxins and hyperinflammation driven by excess leukotriene B(4).
Association analysis of the LTA4H gene polymorphisms and pulmonary tuberculosis in 9115 subjects.
GeneRIF
Nejentsev et al., Cambridge, United Kingdom. In Tuberculosis (edinb), 2011
common polymorphisms in the LTA4H gene do not play any major role in susceptibility to clinical pulmonary tuberculosis
The role of ALOX5AP, LTA4H and LTB4R polymorphisms in determining baseline lung function and COPD susceptibility in UK smokers.
GeneRIF
Sayers et al., Nottingham, United Kingdom. In Bmc Med Genet, 2010
It was found modest association with LTA4H rs1978331C (intron 11) with increased FEV1 (p = 0.029) and with increased FEV1/FVC ratio (p = 0.020).
A critical role for LTA4H in limiting chronic pulmonary neutrophilic inflammation.
Impact
Blalock et al., Birmingham, United States. In Science, 2010
Leukotriene A(4) hydrolase (LTA(4)H) is a proinflammatory enzyme that generates the inflammatory mediator leukotriene B(4) (LTB(4)).
ALOX5AP and LTA4H polymorphisms modify augmentation of bronchodilator responsiveness by leukotriene modifiers in Latinos.
GeneRIF
Genetics of Asthma in Latino Americans Study et al., Cleveland, United States. In J Allergy Clin Immunol, 2010
LTA4H and ALOX5AP gene polymorphisms modify the augmentation of bronchodilator responsiveness by leukotriene modifiers in Puerto Ricans but not Mexicans with asthma.
Modulating the substrate specificity of LTA4H aminopeptidase by using chemical compounds and small-molecule-guided mutagenesis.
GeneRIF
Lai et al., Beijing, China. In Chembiochem, 2010
Several point mutants of LTA4H with altered substrate specificities were designed.
The lta4h locus modulates susceptibility to mycobacterial infection in zebrafish and humans.
Impact
GeneRIF
Ramakrishnan et al., Seattle, United States. In Cell, 2010
In humans, protection from both tuberculosis and multibacillary leprosy is associated with heterozygosity for LTA4H polymorphisms that have previously been correlated with differential LTB(4) production.
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