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Lymphocyte specific 1

LSP1, S37, B lymphocyte-specific, leukocyte-specific protein 1
This gene encodes an intracellular F-actin binding protein. The protein is expressed in lymphocytes, neutrophils, macrophages, and endothelium and may regulate neutrophil motility, adhesion to fibrinogen matrix proteins, and transendothelial migration. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, ACID, HAD, Actin, TNRC9
Papers on LSP1
Posttranslational modification of E-cadherin by core fucosylation regulates Src activation and induces epithelial-mesenchymal transition-like process in lung cancer cells.
Wu et al., Shanghai, China. In Glycobiology, Feb 2016
In Fut8-95C cells, phosphorylation of Akt (Y315, Y326) and GSK-3β (S9) was significantly reduced, but β-catenin (S37) phosphorylation was enhanced.
Probing the Interaction between cHAVc3 Peptide and the EC1 Domain of E-cadherin using NMR and Molecular Dynamics Simulations.
Siahaan et al., Jakarta, Indonesia. In J Biomol Struct Dyn, Feb 2016
The results suggest that cHAVc3 binds to EC1 around residues Y36, S37, I38, I53, F77, S78, H79, and I94.
Association of polymorphisms with a family history of cancer and the presence of germline mutations in the BRCA1/BRCA2 genes.
Palmero et al., Barretos, Brazil. In Hered Cancer Clin Pract, Dec 2015
The constitutive DNA was analyzed for the presence of polymorphisms at rs2981582 (FGFR2 gene); rs3803662 (TNRC9); rs889312 (MAP3K1); rs3817198 (LSP1 gene); and rs13281615 (8q24).
Leukocyte-specific protein 1 regulates T-cell migration in rheumatoid arthritis.
Kim et al., Seoul, South Korea. In Proc Natl Acad Sci U S A, Dec 2015
Here, we identified a novel leukocyte-specific protein 1 (LSP1) deletion variant for RA susceptibility located in 11p15.5.
TNF Inhibitors in Psoriasis: A Review.
Kerdel, Miami, United States. In Semin Cutan Med Surg, Mar 2015
Semin Cutan Med Surg 34(supp2):S37-S39 © 2015 published by Frontline Medical Communications.
Candidate gene-environment interactions in breast cancer.
Dudbridge et al., London, United Kingdom. In Bmc Med, 2013
One of these, an interaction between CASP8-rs1045485 and alcohol consumption has been replicated, but others have not, including LSP1- rs3817198 and parity, and 1p11.2-rs11249433 and ever being parous.
Seg1 controls eisosome assembly and shape.
Walter et al., San Francisco, United States. In J Cell Biol, 2012
Seg1/Sle1 controls eisosome assembly and shape, which also involves Pil1 and Lsp1
Different microvascular permeability responses elicited by the CXC chemokines MIP-2 and KC during leukocyte recruitment: role of LSP1.
Liu et al., Saskatoon, Canada. In Biochem Biophys Res Commun, 2012
LSP1 plays an important role in leukocyte recruitment induced by both KC and MIP-2.
Breast cancer genome-wide association studies: there is strength in numbers.
Russo et al., Palermo, Italy. In Oncogene, 2012
Recently, genome wide association studies (GWAS) in BC revealed single nucleotide polymorphisms (SNPs) in five novel genes associated to susceptibility: TNRC9, FGFR2, MAP3K1, H19 and lymphocyte-specific protein 1 (LSP1).
β-Thalassemia trait association with autoimmune diseases: β-globin locus proximity to the immunity genes or role of hemorphins?
Deniz et al., İstanbul, Turkey. In Immunopharmacol Immunotoxicol, 2012
These associations make sense when considering that the hemoglobin β-chain locus at 11p15.5 resides in close proximity to eight genes with profound roles in immune regulation: STIM1, CD151, TC21/RRAS2, SIGIRR/TOLL/IL1R8, pp52/LSP1 (lymphocyte specific protein), TRIM21, toll interacting protein (TOLLIP) and SLEN3.
Eisosome proteins assemble into a membrane scaffold.
Walther et al., Martinsried, Germany. In J Cell Biol, 2011
Pil1 and Lsp1 self-assemble into higher-order structures and bind preferentially to phosphoinositide-containing membranes.
Association of a LSP1 gene rs3817198T>C polymorphism with breast cancer risk: evidence from 33,920 cases and 35,671 controls.
Lu et al., Kunshan, China. In Mol Biol Rep, 2011
The LSP1 rs3817198T>C polymorphism is a low-penetrant risk factor for developing breast cancer but may not be in Africans.
Genetic polymorphisms and breast cancer risk: evidence from meta-analyses, pooled analyses, and genome-wide association studies.
Lai et al., China. In Breast Cancer Res Treat, 2011
Our results demonstrated that 10 associations were noteworthy: CASP8 (D302H), CHEK2 (*1100delC), CTLA4 (+49G>A), FGFR2 (rs2981582, rs1219648, and rs2420946), HRAS (rare alleles), IL1B (rs1143627), LSP1 (rs3817198), and MAP3K1 (rs889312).
Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.
Rioux et al., Cambridge, United Kingdom. In Nat Genet, 2011
After annotating associated regions using GRAIL, expression quantitative trait loci data and correlations with non-synonymous SNPs, we identified many candidate genes that provide potentially important insights into disease pathogenesis, including IL1R2, IL8RA-IL8RB, IL7R, IL12B, DAP, PRDM1, JAK2, IRF5, GNA12 and LSP1.
Endothelial LSP1 is involved in endothelial dome formation, minimizing vascular permeability changes during neutrophil transmigration in vivo.
Kubes et al., Germany. In Blood, 2011
Data demonstrate that endothelial LSP1 is recruited to the cytoskeleton in inflammation and plays an important role in forming endothelial domes thereby regulating neutrophil transendothelial migration.
Gene-environment interactions in 7610 women with breast cancer: prospective evidence from the Million Women Study.
Million Women Study Collaborators et al., Oxford, United Kingdom. In Lancet, 2010
METHODS: We tested gene-environment interactions in 7610 women who developed breast cancer and 10 196 controls without the disease, studying the effects of 12 polymorphisms (FGFR2-rs2981582, TNRC9-rs3803662, 2q35-rs13387042, MAP3K1-rs889312, 8q24-rs13281615, 2p-rs4666451, 5p12-rs981782, CASP8-rs1045485, LSP1-rs3817198, 5q-rs30099, TGFB1-rs1982073, and ATM-rs1800054) in relation to prospectively collected information about ten established environmental risk factors (age at menarche, parity, age at first birth, breastfeeding, menopausal status, age at menopause, use of hormone replacement therapy, body-mass index, height, and alcohol consumption).
Genome-wide association study identifies five new breast cancer susceptibility loci.
Easton et al., United Kingdom. In Nat Genet, 2010
We also identified SNPs in the 6q25.1 (rs3757318, P = 2.9 x 10(-6)), 8q24 (rs1562430, P = 5.8 x 10(-7)) and LSP1 (rs909116, P = 7.3 x 10(-7)) regions that showed more significant association with risk than those reported previously.
Carbohydrate-specific signaling through the DC-SIGN signalosome tailors immunity to Mycobacterium tuberculosis, HIV-1 and Helicobacter pylori.
Geijtenbeek et al., Amsterdam, Netherlands. In Nat Immunol, 2009
DC-SIGN was constitutively associated with a signalosome complex consisting of the scaffold proteins LSP1, KSR1 and CNK and the kinase Raf-1
Breast cancer susceptibility: current knowledge and implications for genetic counselling.
Schlegelberger et al., Hannover, Germany. In Eur J Hum Genet, 2009
Although candidate gene approaches demonstrated moderately increased breast cancer risks for rare mutations in genes involved in DNA repair (ATM, CHEK2, BRIP1, PALB2 and RAD50), genome-wide association studies identified several SNPs as low-penetrance breast cancer susceptibility polymorphisms within genes as well as in chromosomal loci with no known genes (FGFR2, TOX3, LSP1, MAP3K1, TGFB1, 2q35 and 8q).
Genome-wide association study identifies novel breast cancer susceptibility loci.
Ponder et al., Cambridge, United Kingdom. In Nature, 2007
Four of these contain plausible causative genes (FGFR2, TNRC9, MAP3K1 and LSP1).
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