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Leucyl-tRNA synthetase

LRS, LARS, Leucine-tRNA Ligase
This gene encodes a cytosolic leucine-tRNA synthetase, a member of the class I aminoacyl-tRNA synthetase family. The encoded enzyme catalyzes the ATP-dependent ligation of L-leucine to tRNA(Leu). It is found in the cytoplasm as part of a multisynthetase complex and interacts with the arginine tRNA synthetase through its C-terminal domain. Alternatively spliced transcript variants of this gene have been found; however, their full-length nature is not known. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: HAD, CAN, ACID, V1a, PrP
Papers on LRS
A correlation analysis between HDAC1 over-expression and clinical features of laryngeal squamous cell carcinoma.
New
Liu et al., Harbin, China. In Acta Otolaryngol, Feb 2016
In addition, another 40 LSCC samples were collected that were divided into two groups after 3-month radiotherapy: the high radio-sensitive group (HRS) and low radio-sensitive group (LRS).
Clinical and genetic characterisation of infantile liver failure syndrome type 1, due to recessive mutations in LARS.
New
Crushell et al., Dublin, Ireland. In J Inherit Metab Dis, Nov 2015
BACKGROUND: Recessive LARS mutations were recently reported to cause a novel syndrome, infantile liver failure syndrome type 1 (ILFS1), in six Irish Travellers.
First Report of Korean Cyst Nematode, Heterodera koreana, Parasitic on Bamboo, Phyllostachys nigra, from Iran.
New
Taheri et al., Tehrān, Iran. In J Nematol, Sep 2015
A main area allocated for bamboo growing is located in Lahidjan Agricultural Research Station (LARS) in the north of Iran, where several species of bamboo were cultivated in an area of 5 ha.
Systemic Inflammation Associated With World Trade Center Dust Exposures and Airway Abnormalities in the Local Community.
New
Reibman et al., New York City, United States. In J Occup Environ Med, Jun 2015
We evaluated whether systemic inflammation measured by C-reactive protein was associated with WTC dust exposures, persistent LRS, and lung function.
Influence of breed and genotype on the onset and distribution of infectivity and disease-associated prion protein in sheep following oral infection with the bovine spongiform encephalopathy agent.
González et al., Penicuik, United Kingdom. In J Comp Pathol, 2015
In MARQ/MARQ sheep of both breeds, initial PrP(d) accumulation was identified in lymphoreticular system (LRS) tissues followed by the central nervous system (CNS) and enteric nervous system (ENS) and finally by the autonomic nervous system and peripheral nervous system and other organs.
TCR-mediated functions are enhanced in activated peripheral blood T cells isolated from leucocyte reduction systems.
Houtman et al., Iowa City, United States. In J Immunol Methods, 2015
Buffy coats are the most common method for the acquisition of activated primary human T cells for research or clinical applications, but recently leukocyte reduction system (LRS) cones have emerged as a viable source for these cells.
Evaluation of Multi-tRNA Synthetase Complex by Multiple Reaction Monitoring Mass Spectrometry Coupled with Size Exclusion Chromatography.
Lee et al., Seoul, South Korea. In Plos One, 2014
Eight aminoacyl-tRNA synthetases (M, K, Q, D, R, I, EP and LARS) and three auxiliary proteins (AIMP1, 2 and 3) are known to form a multi-tRNA synthetase complex (MSC) in mammalian cells.
A human leucyl-tRNA synthetase as an anticancer target.
Li et al., Shanghai, China. In Onco Targets Ther, 2014
In this study, we aimed to explore the potential role of leucyl-tRNA synthetase (LARS) as an anticancer target.
A novel genetic locus linked to pro-inflammatory cytokines after virulent H5N1 virus infection in mice.
Webby et al., Saint Louis, United States. In Bmc Genomics, 2013
Linkage analysis of cytokine concentration revealed a significant locus on chromosome 6 associated with differences in TNFα, IFN-α and CCL2 cytokine concentration (LRS =26).
Protein-protein interactions and multi-component complexes of aminoacyl-tRNA synthetases.
Review
Kim et al., Seoul, South Korea. In Top Curr Chem, 2013
The mammalian multi-tRNA synthetase complex (MSC) consists of eight different enzymes: EPRS, IRS, LRS, QRS, MRS, KRS, RRS, and DRS, and three auxiliary proteins: AIMP1/p43, AIMP2/p38, and AIMP/p18.
Exosome release from infected dendritic cells: a clue for a fast spread of prions in the periphery?
Review
Collinge et al., London, United Kingdom. In J Infect, 2013
In many natural and experimental prion diseases, infectious prions can be detected in the lymphoreticular system (LRS) long before they reach the brain where they cause a fatal rapidly progressive degeneration.
Respiratory manifestations of gastroesophageal reflux disease.
Review
Chan et al., Birmingham, United States. In Ann N Y Acad Sci, 2013
The following commentaries on respiratory manifestations of GERD address evidence for a role of a vagally mediated bronchoconstriction reflex in the development of asthma; the direct effects of airway obstruction on lower esophageal sphincter (LES) pressure and reflux episodes; the mechanisms by which reflux may play roles in chronic cough and airway stenosis; the limited efficacy of laparoscopic antireflux surgery (LARS) in improving GERD-related respiratory symptoms; the search for a marker for microaspiration and reflux-induced airway disease; and the potential of proton pump inhibitor (PPI) treatment for patients presenting with asthma and GERD.
Identification of a mutation in LARS as a novel cause of infantile hepatopathy.
GeneRIF
Ennis et al., Dublin, Ireland. In Mol Genet Metab, 2012
Identification of a mutation in LARS as a novel cause of infantile hepatopathy
Leucyl-tRNA synthetase is an intracellular leucine sensor for the mTORC1-signaling pathway.
Impact
GeneRIF
Kim et al., Seoul, South Korea. In Cell, 2012
This work demonstrates that LRS is a key mediator for amino acid signaling to mTORC1.
Modular pathways for editing non-cognate amino acids by human cytoplasmic leucyl-tRNA synthetase.
GeneRIF
Wang et al., Shanghai, China. In Nucleic Acids Res, 2011
hcLeuRS can charge RNALeu with non-cognate amino acids and exclude the incorrect products by multiple editing pathways.
Silent information regulator 3: the Goldilocks of the silencing complex.
Review
Boeke et al., Baltimore, United States. In Genes Dev, 2010
Specifically, the N-terminal bromo-adjacent homology (BAH) domain plays a now well-defined role in silencing, and a picture is emerging in which both termini of Sir3p bind two locations on the nucleosome: (1) the loss of ribosomal DNA silencing (LRS) surface in the nucleosome core, and (2) the N-terminal histone tails for effective silencing at telomeres.
A paradigm shift for the amino acid editing mechanism of human cytoplasmic leucyl-tRNA synthetase.
GeneRIF
Martinis et al., Urbana, United States. In Biochemistry, 2009
the introduction of bulky residues into the amino acid binding pocket failed to block deacylation of tRNA, indicating that the architecture of the amino acid binding pocket is different compared to that of other characterized LeuRSs
Crystal structures of the human and fungal cytosolic Leucyl-tRNA synthetase editing domains: A structural basis for the rational design of antifungal benzoxaboroles.
GeneRIF
Cusack et al., Grenoble, France. In J Mol Biol, 2009
Study of crystal structures of the editing domain from 2 eukaryotic cytosolic LeuRS; shows a conserved structural core containing the active site for hydrolysis, with distinct bacterial, archeal, or eukaryotic peripheral insertions.
IL-5 and IL-5 receptor in asthma.
Review
Hamid et al., Montréal, Canada. In Mem Inst Oswaldo Cruz, 1996
Finally, there are several animal, and more recently in vitro lung explant, models of allergen induced eosinophilia, late airway responses (LARS), and bronchial hyperresponsiveness (BHR)--all of which support a link between IL-5 and airway eosinophilia and bronc
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