Parkinson's disease proteins: Novel mitochondrial targets for cardioprotection.
Singapore, Singapore. In Pharmacol Ther, Dec 2015
In dopaminergic neurons of the substantia nigra, these PD proteins, which include Parkin, PINK1, DJ-1, LRRK2, and α-synuclein, play essential roles in preventing cell death-through maintaining normal mitochondrial function, protecting against oxidative stress, mediating mitophagy, and preventing apoptosis.
Commensal bacteria direct selective cargo sorting to promote symbiosis.
Beijing, China. In Nat Immunol, Sep 2015
Here we report that in mice symbiotic bacteria directed selective cargo sorting in Paneth cells to promote symbiosis through Nod2, a cytosolic bacterial sensor, and the multifunctional protein kinase LRRK2, both encoded by inflammatory bowel disease (IBD)-associated genes.
The associations between Parkinson's disease and cancer: the plot thickens.
Boston, United States. In Transl Neurodegener, 2014
This positive association has been supported by several common genetic mutations in SNCA, PARK2, PARK8, ATM, p53, PTEN, and MC1R resulting in cellular changes such as mitochondrial dysfunction, aberrant protein aggregation, and cell cycle dysregulation.
Genetic perspective on the role of the autophagy-lysosome pathway in Parkinson disease.
Montréal, Canada. In Autophagy, 2014
Interestingly, many of these genetic factors, such as LRRK2, GBA, SMPD1, SNCA, PARK2, PINK1, PARK7, SCARB2, and others, are involved in the autophagy-lysosome pathway (ALP).
Multiplying messages LRRK beneath Parkinson disease.
More papers using
Ann Arbor, United States. In Cell, 2014
link PD protein leucine-rich repeat kinase 2 (LRRK2) to abnormalities of translational control, a pathogenic mechanism implicated in an increasing number of CNS neurodegenerative diseases, as well as in normal aging.