Protective and Toxic roles of dopamine in Parkinson's Disease.
Santiago, Chile. In J Neurochem, 18 Mar 2014
The discovery of genes associated with Parkinson's disease (such as alpha synuclein, parkin, DJ-1, UCHL-1, PINK-1, LRRK2, ATP13A, etc.) contributed enormously to basic research towards understanding the role of these proteins in the sporadic form of the disease.
Lysosomal impairment in Parkinson's disease.
Bordeaux, France. In Mov Disord, Jun 2013
Furthermore, other PD-related genes, such as leucine-rich repeat kinase-2 (LRRK2), parkin, and phosphatase and tensin homolog (PTEN)-induced putative kinase 1 (PINK1), have been mechanistically linked to alterations in ALPs.
Progressive degeneration of human neural stem cells caused by pathogenic LRRK2.
Beijing, China. In Nature, 2012
We decided to evaluate nuclear organization in the context of ageing-associated disorders by focusing on a leucine-rich repeat kinase 2 (LRRK2) dominant mutation (G2019S; glycine-to-serine substitution at amino acid 2019), which is associated with familial and sporadic Parkinson's disease as well as impairment of adult neurogenesis in mice.
Pathological roles of α-synuclein in neurological disorders.
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Athens, Greece. In Lancet Neurol, 2011
α-Synuclein also seems to be linked to other genetic forms of Parkinson's disease, such as those linked to mutations in GBA or LRRK2, possibly through common effects on autophagy and lysosomal function.