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Leucine-rich repeat kinase 2

LRRK2, leucine-rich repeat kinase 2, PARK8
This gene is a member of the leucine-rich repeat kinase family and encodes a protein with an ankryin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane. Mutations in this gene have been associated with Parkinson disease-8. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: AGE, CAN, E3 ubiquitin ligase, PINK1, HAD
Papers using LRRK2 antibodies
The role of leucine-rich repeat kinase 2 (LRRK2) in Parkinson's disease.
Supplier
Lightowlers Bob, In PLoS ONE, 2009
... For LRRK2, rabbit monoclonal MJFF2 (Epitomics – see ...
LRRK2 G2019S mutations are associated with an increased cancer risk in Parkinson disease
Supplier
Kahle Philipp J., In PLoS ONE, 2009
... ReagentsAll cell culture media and supplements, BacMam LRRK2-GFP reagents, PrestoBlue™ cell viability assay reagent, Western blotting reagents and human neural stem cells were obtained from Life Technologies (Carlsbad, CA) ...
Aggregate formation and toxicity by wild-type and R621C synphilin-1 in the nigrostriatal system of mice using adenoviral vectors
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Xia Xu-Gang et al., In International Journal of Biological Sciences, 2008
... LRRK2 and tTA transgenic rats were produced by ...
Phosphorylation at Ser-129 but not the phosphomimics S129E/D inhibits the fibrillation of alpha-synuclein.
Supplier
Feany Mel B., In PLoS ONE, 2007
... Full length WT-LRRK2 pCMV6-XL5 was purchased from Origene (NM_198578.2) ...
Tyramine and octopamine independently inhibit serotonin-stimulated aversive behaviors in Caenorhabditis elegans through two novel amine receptors.
Supplier
Hart Anne C., In PLoS ONE, 2006
... driven WT or mutant LRRK2 constructs, were injected with the co-injection marker, promoter of nmr-1 driven YFP2 [55], into transgenic wild type nematode lines ...
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Papers on LRRK2
Commensal bacteria direct selective cargo sorting to promote symbiosis.
New
Impact
Liu et al., Beijing, China. In Nat Immunol, 30 Sep 2015
Here we report that in mice symbiotic bacteria directed selective cargo sorting in Paneth cells to promote symbiosis through Nod2, a cytosolic bacterial sensor, and the multifunctional protein kinase LRRK2, both encoded by inflammatory bowel disease (IBD)-associated genes.
Greater motor progression in patients with Parkinson disease who carry LRRK2 risk variants.
New
Tan et al., United States. In Neurology, 26 Sep 2015
OBJECTIVES: In a longitudinal follow-up study, we compared the clinical features and motor progression of patients with Parkinson disease (PD) who are carriers of the leucine-rich repeat kinase 2 (LRRK2) gene risk variants with patients who are noncarriers.
Conformational heterogeneity of the Roc domains in C. tepidum Roc-COR and implications for human LRRK2 Parkinson mutations.
New
Klare et al., Osnabrück, Germany. In Biosci Rep, 26 Sep 2015
Mutations in the most prominent member of the Roco family of proteins, leucine-rich repeat kinase 2 (LRRK2), are the most frequent cause of late-onset Parkinson's disease (PD).
Clinical and imaging markers in premotor LRRK2 G2019S mutation carriers.
New
Tolosa et al., Barcelona, Spain. In Parkinsonism Relat Disord, 12 Sep 2015
Asymptomatic LRRK2 mutation carriers (aLRRK2+), at high risk for developing PD, provide an opportunity for the study of preclinical biomarkers.
Chronic and acute LRRK2 silencing has no long-term behavioral effects, whereas wild-type and mutant LRRK2 overexpression induce motor and cognitive deficits and altered regulation of dopamine release.
New
Milnerwood et al., Canada. In Parkinsonism Relat Disord, 01 Sep 2015
INTRODUCTION: Germline silencing of the PD-related protein LRRK2 does not alter glutamate or dopamine release in adult mice, but some exploratory abnormalities have been reported with ageing.
Pathways to Parkinsonism Redux: Convergent pathobiological mechanisms in genetics of Parkinson's disease.
Review
New
Cookson et al., Bethesda, United States. In Hum Mol Genet, 22 Jul 2015
Here we will focus on those genes nominated by genome-wide association studies (GWAS) in sporadic PD, with a particular emphasis on genes that overlap between familial and sporadic disease such as those encoding a-synuclein (SNCA), tau (MAPT) and leucine-rich repeat kinase 2 (LRRK2).
LRRK2 mutations and neurotoxicant susceptibility.
Review
New
Cannon et al., West Lafayette, United States. In Exp Biol Med (maywood), Jun 2015
Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common cause of hereditary PD.
Parkinson's Disease in Saudi Patients: A Genetic Study.
New
Al Tassan et al., Riyadh, Saudi Arabia. In Plos One, Dec 2014
Here we investigated the genetic causes of PD in Saudis by recruiting 98 PD-cases (sporadic and familial) and screening them for potential pathogenic mutations in PD-established genes; SNCA, PARKIN, PINK1, PARK7/DJ1, LRRK2 and other PD-associated genes using direct sequencing.
Role of α- and β-Synucleins in the Axonal Pathology of Parkinson's Disease and Related Synucleinopathies.
Review
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Hashimoto et al., Tokyo, Japan. In Biomolecules, Dec 2014
However, other pathological features, such as abnormal mitochondria, enhanced oxidative stress and LRRK2 accumulation, were observed in the αS-globules, but not in the βS-globules.
The Role of α-Synuclein and LRRK2 in Tau Phosphorylation.
Review
New
Ichikawa et al., Sagamihara, Japan. In Parkinsons Dis, Dec 2014
In this review, we discuss the physiological role of α-synuclein and LRRK2 in the abnormal phosphorylation of tau.
Multiplying messages LRRK beneath Parkinson disease.
New
Impact
Guo et al., Ann Arbor, United States. In Cell, May 2014
link PD protein leucine-rich repeat kinase 2 (LRRK2) to abnormalities of translational control, a pathogenic mechanism implicated in an increasing number of CNS neurodegenerative diseases, as well as in normal aging.
Ribosomal protein s15 phosphorylation mediates LRRK2 neurodegeneration in Parkinson's disease.
New
Impact
Dawson et al., Baltimore, United States. In Cell, May 2014
Mutations in leucine-rich repeat kinase 2 (LRRK2) are a common cause of familial and sporadic Parkinson's disease (PD).
[Molecular basis of Parkinson's disease linked with mutations in the LRRK2 gene].
Review
Usenko et al., In Mol Biol (mosk), 2014
Despite of the fact that mutations in the leucine-rich repeat kinase (LRRK2) gene are the most common cause of inherited forms of PD known today, the mechanisms by which mutations in the LRRK2 gene lead to disease remain unclear.
Genetic correction of a LRRK2 mutation in human iPSCs links parkinsonian neurodegeneration to ERK-dependent changes in gene expression.
Impact
Sterneckert et al., Germany. In Cell Stem Cell, 2013
The LRRK2 mutation G2019S is the most common genetic cause of Parkinson's disease (PD).
Progressive degeneration of human neural stem cells caused by pathogenic LRRK2.
Impact
Izpisua Belmonte et al., Beijing, China. In Nature, 2012
We decided to evaluate nuclear organization in the context of ageing-associated disorders by focusing on a leucine-rich repeat kinase 2 (LRRK2) dominant mutation (G2019S; glycine-to-serine substitution at amino acid 2019), which is associated with familial and sporadic Parkinson's disease as well as impairment of adult neurogenesis in mice.
[The absence of the common LRRK2 G2019S mutation in 120 young onset Hungarian Parkinon's disease patients].
GeneRIF
Molnár et al., Budapest, Hungary. In Ideggyogy Sz, 2012
Data suggest that the mutation LRRK2 G2019S may be a rare cause of Parkinson disease in the Hungarian population.
Roco kinase structures give insights into the mechanism of Parkinson disease-related leucine-rich-repeat kinase 2 mutations.
GeneRIF
Kortholt et al., Groningen, Netherlands. In Proc Natl Acad Sci U S A, 2012
data give important insight in the LRRK2 activation mechanism and, most importantly, explain the G2019S-related increase in LRRK2 kinase activity
Number and brightness analysis of LRRK2 oligomerization in live cells.
GeneRIF
Jameson et al., Honolulu, United States. In Biophys J, 2012
results show, for the first time to our knowledge, that LRRK2 is predominantly monomeric throughout the cytosol of living cells, but attains predominately higher oligomeric states in the plasma membrane
GST P1, a novel downstream regulator of LRRK2, G2019S-induced neuronal cell death.
GeneRIF
Chen et al., Shanghai, China. In Front Biosci (elite Ed), 2011
results suggest a previously undefined signaling mechanism underlying the neurotoxic effect of LRRK2 (G2019S), in which LRRK2 (G2019S) triggers oxidative stress in cells
Evaluation of the role of LRRK2 gene in Parkinson's disease in an East Indian cohort.
GeneRIF
Ray et al., Calcutta, India. In Dis Markers, 2011
LRRK2 has minimal role as a candidate and susceptibility gene in Parkinson's disease pathogenesis among East Indians.
More papers using LRRK2 antibodies
Purification and characterization of Rac 2. A cytosolic GTP-binding protein that regulates human neutrophil NADPH oxidase.
Supplier
Kahle Philipp J., In PLoS ONE, 1991
... The DR4A/3EDD anti-LRRK2-kinase domain antibody is described in reference [35] and goat polyclonal anti 14-3-3 antibody was purchased from Santa Cruz (Santa Cruz Biotechnology, Santa Cruz, CA, USA) ...
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