Calcium homeostasis modulator (CALHM) ion channels.
Philadelphia, United States. In Pflugers Arch, Dec 2015
Through convergent evolution, CALHM has structural features that are reminiscent of connexins and pannexins/innexins/LRRC8 (volume-regulated anion channel (VRAC)) gene families, including four transmembrane helices with cytoplasmic amino and carboxyl termini.
TMEM16, LRRC8A, bestrophin: chloride channels controlled by Ca(2+) and cell volume.
Regensburg, Germany. In Trends Biochem Sci, Sep 2015
Recent years, however, have shown remarkable progress, and these channels have been identified as TMEM16A (anoctamin 1), LRRC8A (swell 1), and bestrophin 1 (BEST1), and structural information is already available for the Ca(2+)-activated channels bestrophin and TMEM16.