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Leucine rich repeat containing 2

LRRC2, leucine-rich repeat-containing 2
This gene encodes a member of the leucine-rich repeat-containing family of proteins, which function in diverse biological pathways. This family member may possibly be a nuclear protein. Similarity to the RAS suppressor protein, as well as expression down-regulation observed in tumor cells, suggests that it may function as a tumor suppressor. The gene is located in the chromosome 3 common eliminated region 1 (C3CER1), a 1.4 Mb region that is commonly deleted in diverse tumors. A related pseudogene has been identified on chromosome 2. [provided by RefSeq, Sep 2011] (from NCBI)
Top mentioned proteins: Cer, FYCO1, ZEB1, ErbB4, miR
Papers on LRRC2
Tobacco smoking is associated with methylation of genes related to coronary artery disease.
Dehghan et al., Rotterdam, Netherlands. In Clin Epigenetics, 2014
These sites were located in the genes TERT, SARS, GNGT2, SMG6, SKI, TOM1L2, SIPA1, MRAS, CDKN1A, LRRC2, FES and RPH3A.
Transcriptome analysis of CD133-positive stem cells and prognostic value of survivin in colorectal cancer.
Kim et al., Seoul, South Korea. In Cancer Genomics Proteomics, 2014
RESULTS: We found that in CD133(+) cells, 17 genes (RNASE2, PRB2, IL4, MGC27382, CLEC4C, SALL3, GIMAP1, ISG15, LOC728875, ZIK1, ICAM2, CCDC7, CDYL2, LRRC2, ZEB1, OSTF1 and CCDC144B) were significantly up-regulated compared to CD133(-) CRC cells.
Identifying mRNA targets of microRNA dysregulated in cancer: with application to clear cell Renal Cell Carcinoma.
Bhanot et al., United States. In Bmc Syst Biol, 2009
For instance, loss of miR-149, miR-200c and mir-141 causes gain of function of oncogenes (KCNMA1, LOX), VEGFA and SEMA6A respectively and increased levels of miR-142-3p, miR-185, mir-34a, miR-224, miR-21 cause loss of function of tumor suppressors LRRC2, PTPN13, SFRP1, ERBB4, and (SLC12A1, TCF21) respectively.
Down regulation of 3p genes, LTF, SLC38A3 and DRR1, upon growth of human chromosome 3-mouse fibrosarcoma hybrids in severe combined immunodeficiency mice.
Imreh et al., Stockholm, Sweden. In Int J Cancer, 2006
Notably that transcription of the LTF and 2 flanking genes, LRRC2 and TMEM7, as well as transcription of the SLC38A3 gene, were also impaired in all 5 RCC cell lines analyzed.
Comparative human/murine sequence analysis of the common eliminated region 1 from human 3p21.3.
Imreh et al., Stockholm, Sweden. In Mamm Genome, 2002
We further identified and characterized five novel orthologous mouse genes (Kiaa0028, Xtrp3s1, Fyco1, Tmem7, and Lrrc2).
The transcriptional map of the common eliminated region 1 (C3CER1) in 3p21.3.
Dumanski et al., Stockholm, Sweden. In Eur J Hum Genet, 2002
We report four novel genes: FYVE and coiled-coil domain containing 1 (FYCO1), transmembrane protein 7 (TMEM7), leucine-rich repeat-containing 2 (LRRC2) and leucine zipper protein 3 (LUZP3).
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