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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Low density lipoprotein receptor-related protein 6

LRP6
Top mentioned proteins: Frizzled, DKK1, Wnt3a, CAN, V1a
Papers using LRP6 antibodies
R-spondin1 synergizes with Wnt3A in inducing osteoblast differentiation and osteoprotegerin expression.
Supplier
Mei Lin, In PLoS ONE, 2007
Polyclonal rabbit anti-Cyclin D1 ...
Identification of the Axin and Frat binding region of glycogen synthase kinase-3.
Supplier
Xu Wenqing, In PLoS ONE, 2001
... DNA fragments encoding LRP6 miniCL (residues 1470–1510 of human LRP6) were obtained from a human cDNA library by PCR, and inserted into the pEGFP-C1 vector (Clontech) using ...
Elevated expression of axin2 and hnkd mRNA provides evidence that Wnt/β-catenin signaling is activated in human colon tumors
Supplier
Bu G et al., In Oncogene, 2000
... Purified MMTV–LRP6 DNA fragment was microinjected into the pronuclei of fertilized mouse eggs, and transferred to pseudopregnant mothers by the Transgenic and ES Cell Core ...
A new Drosophila APC homologue associated with adhesive zones of epithelial cells
Supplier
Gottardi Cara J. et al., In The Journal of Cell Biology, 1998
... Byers, Georgetown University, Washington, DC); P33/37/41, P41/45, GSK-3β, Ser9 phospho–GSK-3β, and LRP6 (Cell Signaling Technology); glyceraldehyde 3-phosphate dehydrogenase ...
Papers on LRP6
SFRP2 augments WNT16B signaling to promote therapeutic resistance in the damaged tumor microenvironment.
New
Xu et al., Shanghai, China. In Oncogene, Feb 2016
WNT16B recognizes cancer cell surface receptors including frizzled (FZD) 3/4/6, a process enhanced by SFRP2, coordinated by the co-receptor LRP6 but subject to abrogation by DKK1.
Wnt3a suppresses Wnt/β-catenin signalling and cancer cell proliferation following serum deprivation.
New
Zhu et al., Shanghai, China. In Exp Cell Res, Dec 2015
The internalization of Wnt co-receptor low-density lipoprotein receptor-related protein 6 (LRP6) induced by Wnt ligands is commonly thought to be critical for Wnt/β-catenin signalling activation.
Impaired LRP6-TCF7L2 Activity Enhances Smooth Muscle Cell Plasticity and Causes Coronary Artery Disease.
New
Mani et al., New Haven, United States. In Cell Rep, Nov 2015
Mutations in Wnt-signaling coreceptor LRP6 have been linked to coronary artery disease (CAD) by unknown mechanisms.
Genetic Approaches To Identifying Novel Osteoporosis Drug Targets.
Review
New
Brommage, The Woodlands, United States. In J Cell Biochem, Oct 2015
In addition to the classic Wnt signaling targets DKK1 and sclerostin, LRP4, LRP5/LRP6, SFRP4, WNT16, and NOTUM can potentially be targeted to modulate Wnt signaling.
TPO-Induced Metabolic Reprogramming Drives Liver Metastasis of Colorectal Cancer CD110+ Tumor-Initiating Cells.
New
Impact
Li et al., Shanghai, China. In Cell Stem Cell, Aug 2015
Lysine catabolism generates acetyl-CoA, which is used in p300-dependent LRP6 acetylation.
Low-Density Lipoprotein Receptor-Related Protein 6 (LRP6) Is a Novel Nutritional Therapeutic Target for Hyperlipidemia, Non-Alcoholic Fatty Liver Disease, and Atherosclerosis.
Review
New
Go, Seoul, South Korea. In Nutrients, Jun 2015
Low-density lipoprotein receptor-related protein 6 (LRP6) is a member of the low-density lipoprotein receptor family and has a unique structure, which facilitates its multiple functions as a co-receptor for Wnt/β-catenin signaling and as a ligand receptor for endocytosis.
Keeping Wnt signalosome in check by vesicular traffic.
Review
New
Gao et al., Newark, United States. In J Cell Physiol, Jun 2015
Updates are provided for the regulatory mechanisms related to the three critical cell surface complexes, Wnt-Fzd-LRP6, Dkk1-Kremen-LRP6, and R-spondin-LGR5-RNF43, which potently influence Wnt signaling.
LRP receptor family member associated bone disease.
Review
New
Johnson et al., Kansas City, United States. In Rev Endocr Metab Disord, Jun 2015
In this review we discuss some of the most recent reports (in the past 2 years) highlighting the involvement of the members of the LRP family (LRP5, LRP6, LRP4, and more recently LRP8) in the maintenance of bone and their implications in bone diseases.
LRP5 regulates human body fat distribution by modulating adipose progenitor biology in a dose- and depot-specific fashion.
New
Impact
Christodoulides et al., Oxford, United Kingdom. In Cell Metab, Mar 2015
Rare mutations in the WNT co-receptors LRP5 and LRP6 are similarly associated with bone and cardiometabolic disorders.
Tumor-selective peptide-carrier delivery of Paclitaxel increases in vivo activity of the drug.
Bracci et al., Siena, Italy. In Sci Rep, 2014
NT4 selectively targets tumor cells by binding to membrane sulfated glycosaminoglycans (GAG) and to endocytic receptors, like LRP1 and LRP6, which are established tumor markers.
Extracellular modulators of Wnt signalling.
Review
Jones et al., United States. In Curr Opin Struct Biol, 2014
Structures include Wnt in complex with the cysteine-rich domain (CRD) of Frizzled, extracellular fragments of Wnt co-receptor LRP6, LRP6-binding antagonists Dickkopf and Sclerostin, antagonists 5T4/WAIF1 and Wnt inhibitory factor 1 (WIF-1), as well as Frizzled-ubiquitin ligases ZNRF3/RNF43 (in isolation and in complexes with Wnt signalling promoters R-spondins and LGR5).
A functional connectome: regulation of Wnt/TCF-dependent transcription by pairs of pathway activators.
Dale et al., Napoli, Italy. In Mol Cancer, 2014
METHODS: Mammalian cells engineered to have a partially-active level of Wnt/β-catenin signaling were screened by transfection for proteins that up or down-regulated a mid-level of TCF-dependent transcription induced by transient expression of an activated LRP6 Wnt co-receptor (∆NLRP).
The combined hyperlipidemia caused by impaired Wnt-LRP6 signaling is reversed by Wnt3a rescue.
Review
Impact
Mani et al., New Haven, United States. In Cell Metab, 2014
Rare, nonconservative mutations in the Wnt coreceptor, LRP6, underlie autosomal dominant atherosclerosis, combined hyperlipidemia, and fatty liver disease.
Wnt stabilization of β-catenin reveals principles for morphogen receptor-scaffold assemblies.
Impact
He et al., Boston, United States. In Science, 2013
Wnt signaling stabilizes β-catenin through the LRP6 receptor signaling complex, which antagonizes the β-catenin destruction complex.
LRP6 enhances glucose metabolism by promoting TCF7L2-dependent insulin receptor expression and IGF receptor stabilization in humans.
Impact
Mani et al., New Haven, United States. In Cell Metab, 2013
A rare nonconservative mutation in Wnt coreceptor LRP6 (LRP6(R611C)) has been shown to underlie autosomal dominant early onset coronary artery disease, type 2 diabetes, and metabolic syndrome.
Involvement of the glycogen synthase kinase-3 signaling pathway in TBI pathology and neurocognitive outcome.
GeneRIF
Pati et al., Houston, United States. In Plos One, 2010
Traumatic brain injury caused a rapid, but transient, increase in LRP6 phosphorylation that is followed by a modest decrease in ss-Catenin phosphorylation. Phospho-GSK-3beta immunoreactivity was found to increase three days post injury.
Blocking the Wnt pathway, a unifying mechanism for an angiogenic inhibitor in the serine proteinase inhibitor family.
GeneRIF
Ma et al., Oklahoma City, United States. In Proc Natl Acad Sci U S A, 2010
SERPINA3K is a high-affinity, endogenous antagonist of LRP6
DKK1 antagonizes Wnt signaling without promotion of LRP6 internalization and degradation.
GeneRIF
He et al., Boston, United States. In J Biol Chem, 2008
DKK1 inhibition of LRP6 is independent of LRP6 internalization and degradation
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