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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Leucine-rich repeats and immunoglobulin-like domains 3

Top mentioned proteins: EGFR, CAN, AGE, SET, HAD
Papers on LRIG3
Variants in the genes DCTN2, DNAH10, LRIG3, and MYO1A are associated with intermediate Charcot-Marie-Tooth disease in a Norwegian family.
Russell et al., Oslo, Norway. In Acta Neurol Scand, Nov 2015
Exome sequencing revealed a singular heterozygous shared haplotype containing four genes, DCTN2, DNAH10, LRIG3, and MYO1A, with novel sequence variants.
LRIG3 modulates proliferation, apoptosis and invasion of glioblastoma cells as a potent tumor suppressor.
Lei et al., Wuhan, China. In J Neurol Sci, Apr 2015
It has been reported that perinuclear LRIG3 staining correlated with low WHO grade of glioma and better survival of the patients.
Genomic signatures reveal new evidences for selection of important traits in domestic cattle.
Liu et al., College Park, United States. In Mol Biol Evol, Mar 2015
In addition to well-known genes such as KIT, MC1R, ASIP, GHR, LCORL, NCAPG, WIF1, and ABCA12, we found evidence for a variety of novel and less-known genes under selection in cattle, such as LAP3, SAR1B, LRIG3, FGF5, and NUDCD3.
LRIG1 is a prognostic biomarker in non-small cell lung cancer.
Hedman et al., Umeå, Sweden. In Acta Oncol, 2014
RESULTS: Expression of the LRIG1 protein was found to be an independent prognostic factor in NSCLC, whereas expression of LRIG2 or LRIG3 did not correlate with patient survival.
Expression and significance of LRIG3 in human cervical squamous cell carcinoma.
Zhang et al., In Eur J Gynaecol Oncol, 2014
OBJECTIVE: To explore the effect of LRIG3 in the development of cervical squamous cell carcinoma.
LRIG and cancer prognosis.
Hedman et al., Umeå, Sweden. In Acta Oncol, 2014
MATERIAL AND METHODS: Relevant literature was identified on PubMed using the key words lrig1, lrig2, and lrig3.
The LRIG family: enigmatic regulators of growth factor receptor signaling.
Sweeney et al., Sacramento, United States. In Endocr Relat Cancer, 2013
The leucine-rich repeats and immunoglobulin-like domains (LRIG) family of transmembrane proteins contains three vertebrate members (LRIG1, LRIG2 and LRIG3) and one member each in flies (Lambik) and worms (Sma-10).
Leucine-rich repeat and immunoglobulin domain-containing protein-1 (Lrig1) negative regulatory action toward ErbB receptor tyrosine kinases is opposed by leucine-rich repeat and immunoglobulin domain-containing protein 3 (Lrig3).
Sweeney et al., Sacramento, United States. In J Biol Chem, 2013
Lrig1 is the founding member of the Lrig family of transmembrane leucine-rich repeat proteins, which also includes Lrig2 and Lrig3.
LRIG1 is a triple threat: ERBB negative regulator, intestinal stem cell marker and tumour suppressor.
Coffey et al., Nashville, United States. In Br J Cancer, 2013
We will summarise studies of LRIG1 expression in human cancers and discuss possible related roles for LRIG2 and LRIG3.
Over-expression of LRIG3 suppresses growth and invasion of bladder cancer cells.
Zhuang et al., Wuhan, China. In J Huazhong Univ Sci Technolog Med Sci, 2013
The purpose of this study was to investigate the impact of leucine-rich repeats and immunoglobulin-like domains 3 (LRIG3) on the biological features of bladder cancer cell lines.
Expression of LRIG1 and LRIG3 correlates with human papillomavirus status and patient survival in cervical adenocarcinoma.
Andersson et al., Stockholm, Sweden. In Int J Oncol, 2013
The human leucine-rich repeats and immunoglobulin-like domains (LRIG) gene family includes: LRIG1, LRIG2 and LRIG3.
In vivo analysis of Lrig genes reveals redundant and independent functions in the inner ear.
Goodrich et al., Boston, United States. In Plos Genet, 2012
In mammals, there are three family members - Lrig1, Lrig2, and Lrig3--that are defined by closely related extracellular domains with a similar arrangement of leucine rich repeats and immunoglobulin domains.
Lrig2-deficient mice are protected against PDGFB-induced glioma.
Hedman et al., Umeå, Sweden. In Plos One, 2012
BACKGROUND: The leucine-rich repeats and immunoglobulin-like domains (LRIG) proteins constitute an integral membrane protein family that has three members: LRIG1, LRIG2, and LRIG3.
Activin and BMP4 synergistically promote formation of definitive endoderm in human embryonic stem cells.
Dunn et al., Singapore, Singapore. In Stem Cells, 2012
Several of these, including APLNR, LRIG3, MCC, LEPREL1, ROR2, and LZTS1, are expressed in the mouse primitive streak, the site of DE formation.
Vertebrate Lrig3-ErbB interactions occur in vitro but are unlikely to play a role in Lrig3-dependent inner ear morphogenesis.
Goodrich et al., Boston, United States. In Plos One, 2009
Results suggest that although both Lrig1 and Lrig3 can interact with ErbB receptors in vitro, modulation of Neuregulin signaling is unlikely to contribute to Lrig3-dependent processes of inner ear morphogenesis.
Inhibition of LRIG3 gene expression via RNA interference modulates the proliferation, cell cycle, cell apoptosis, adhesion and invasion of glioblastoma cell (GL15).
Guo et al., Wuhan, China. In Cancer Lett, 2009
LRIG3 may be involved in the regulation of EGF receptor signaling, and serve as a tumor suppressor gene in the pathogenesis of glioma.
Effects of RNAi-mediated gene silencing of LRIG3 expression on cell cycle and survival of glioma cells.
Lei et al., Wuhan, China. In J Huazhong Univ Sci Technolog Med Sci, 2009
siRNA targeting LRIG3 gene shows a dramatic inhibitory effect on RNA transcription and protein expression, then promotes the proliferation and suppresses apoptosis of GL15 cells.
Expression of leucine-rich repeats and immunoglobulin-like domains (LRIG) proteins in human ependymoma relates to tumor location, WHO grade, and patient age.
Henriksson et al., Umeå, Sweden. In Clin Neuropathol, 2009
the expression of LRIG1-3 was evaluated in 51 human ependymomas and was found to be more highly expressed in supratentorial than in infratentorial ependymomas
Effect of RNAi-mediated LRIG3 gene silencing on proliferation of glioma GL15 cells and expression of PCNA and Ki-67.
Lei et al., Wuhan, China. In Ai Zheng, 2009
Down-regulating LRIG3 gene expression can improve the proliferation of glioma GL15 cells.
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