Rennes, France. In Steroids, Nov 2015
Glucocorticoid synthesis regulation in the intestinal epithelial cells is unique in that it does not involve the classical positive regulator steroidogenic factor-1 (SF-1) but a closely related homolog, namely the liver receptor homolog-1 (LRH-1).
Hengyang, China. In Clin Chim Acta, Jul 2015
Multiple factors may influence its expression at both the post-transcriptional and the transcriptional levels both in vivo and ex vivo as follows: hepatocyte nuclear factor-1α, 4α (HNF-1α, 4α), liver receptor homolog-1 (LRH-1), forkhead box A2 (Foxa2) and platelet activating factor (PAF) upregulate its expression; liver X receptor (LXR), retinoid X receptor (RXR), farnesoid X receptor (FXR), small heterodimer partner (SHP) and the majority of cytokines downregulate its expression.
Nuclear receptor variants in liver disease.
Homburg, Germany. In Dig Dis, 2014
Other examples include studies of NR1I2 and NR1I3 polymorphisms in patients with drug-induced liver injury and NR5A2 variation in cholangiocarcinoma.
SUMOylation places LRH-1 in PROXimity to lipid metabolism.
Los Angeles, United States. In Cell Metab, 2014
In this issue of Cell Metabolism, Stein et al. (2014) establish LRH-1 as an important regulator of reverse cholesterol transport and identify SUMOylation as a primary mode of LRH-1 regulation.
Nuclear receptors reverse McGarry's vicious cycle to insulin resistance.
Houston, United States. In Cell Metab, 2012
Here I suggest that reversing this cycle via suppression of the lipogenic transcription factor SREBP-1c is a common thread that connects the antidiabetic effects of a surprising number of nuclear hormone receptors, including CAR, LRH-1, TRβ, ERα, and FXR/SHP.