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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Zinc finger and BTB domain containing 7A

LRF, Pokemon
acts as a transcriptional repressor; may play a role in osteoclastogenesis [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: CAN, HAD, p53, V1a, FSH
Papers on LRF
Evaluation of serum markers in the LRF CLL4 trial: β2m but not serum free light chains, is an independent marker of overall survival.
Oscier et al., Bournemouth, United Kingdom. In Leuk Lymphoma, Feb 2016
The current study evaluated the prognostic significance of serum free light chains (sFLC, kappa and lambda) and other serum markers (β2M, serum thymidine kinase (sTK), soluble CD23 and LDH) together with established biomarkers in 289 patients enrolled into the LRF CLL4 trial.
Effect of volatiles versus exudates released by germinating spores of Gigaspora margarita on lateral root formation.
Tang et al., China. In Plant Physiol Biochem, Dec 2015
Both germinating spore exudates (GSEs) and geminated-spore-emitted volatile organic compounds (GVCs) significantly promoted lateral root formation (LRF) in WT L. japonicus.
Pokemon siRNA Delivery Mediated by RGD-Modified HBV Core Protein Suppressed the Growth of Hepatocellular Carcinoma.
Fang et al., Huaiyin, China. In Hum Gene Ther Methods, Oct 2015
Studies have shown that Pokemon is a master oncogene for HCC growth, suggesting it as an ideal therapeutic target.
Pretreatment Pokemon Level as a Predictor of Response to Cisplatin and Paclitaxel in Patients with Unresectable Non-Small Cell Lung Cancer.
Li et al., Cangzhou, China. In Oncol Res Treat, 2014
BACKGROUND: We firstly investigated the expression of Pokemon in patients with non-small cell lung cancer (NSCLC), then characterized the role of Pokemon in evaluating the response to combined cisplatin and paclitaxel chemotherapy and prognosis.
LRF maintains genome integrity by regulating the non-homologous end joining pathway of DNA repair.
Pandolfi et al., Boston, United States. In Nat Commun, 2014
Leukemia/lymphoma-related factor (LRF) is a POZ/BTB and Krüppel (POK) transcriptional repressor characterized by context-dependent key roles in cell fate decision and tumorigenesis.
A ThPOK-LRF transcriptional node maintains the integrity and effector potential of post-thymic CD4+ T cells.
Bosselut et al., Bethesda, United States. In Nat Immunol, 2014
The transcription factor LRF acts redundantly with ThPOK to prevent the transdifferentiation of mature CD4(+) T cells into CD8(+) T cells.
Role of LRF/Pokemon in lineage fate decisions.
Pandolfi et al., Boston, United States. In Blood, 2013
Here, we focus on functions of leukemia/lymphoma-related factor/POK erythroid myeloid ontogenic factor, which is probably one of the most exciting and yet enigmatic members of the POK/ZBTB family.
New insight into p-glycoprotein as a drug target.
Sulova et al., Bratislava, Slovakia. In Anticancer Agents Med Chem, 2013
Several authors have described a direct influence of P-gp on the function of proteins involved in regulatory pathways, including apoptotic progression (such as p53, caspase-3 and Pokemon).
Biallelic ATM inactivation significantly reduces survival in patients treated on the United Kingdom Leukemia Research Fund Chronic Lymphocytic Leukemia 4 trial.
Stankovic et al., Birmingham, United Kingdom. In J Clin Oncol, 2013
PATIENTS AND METHODS: We analyzed the ATM gene in 224 patients treated on the Leukemia Research Fund Chronic Lymphocytic Leukemia 4 (LRF-CLL4) trial with chlorambucil or fludarabine with and without cyclophosphamide.
Role of postmastectomy radiation after neoadjuvant chemotherapy in stage II-III breast cancer.
Athena Breast Health Network et al., San Francisco, United States. In Int J Radiat Oncol Biol Phys, 2012
PURPOSE: To identify a cohort of women treated with neoadjuvant chemotherapy and mastectomy for whom postmastectomy radiation therapy (PMRT) may be omitted according to the projected risk of local-regional failure (LRF).
Zbtb7 suppresses the expression of CDK2 and E2F4 in liver cancer cells: implications for the role of Zbtb7 in cell cycle regulation.
Jiang et al., Hengyang, China. In Mol Med Report, 2012
The activities of CDK2 and E2F4 promoters were suppressed by the modulation of Zbtb7 levels and that Zbtb7 represses promoter activities through a mechanism involving direct binding of Zbtb7 to the promoters.
POK/ZBTB proteins: an emerging family of proteins that regulate lymphoid development and function.
Maeda et al., Duarte, United States. In Immunol Rev, 2012
LRF (lymphoma/leukemia-related factor), encoded by the ZBTB7A gene, is a transcriptional repressor belonging to the POK (POZ and Krüppel)/ZBTB (zing finger and BTB) protein family.
Stage-specific functions of leukemia/lymphoma-related factor (LRF) in the transcriptional control of osteoclast development.
Takayanagi et al., Tokyo, Japan. In Proc Natl Acad Sci U S A, 2012
study shows that LRF plays stage-specific distinct roles in osteoclast differentiation, exemplifying the delicate transcriptional regulation at work in lineage commitment
FBI-1 promotes cell proliferation and enhances resistance to chemotherapy of hepatocellular carcinoma in vitro and in vivo.
Qin et al., Changsha, China. In Cancer, 2012
The current findings indicated that FBI-1 plays an important role in HCC carcinogenesis and chemotherapy tolerance
Mutational status of the TP53 gene as a predictor of response and survival in patients with chronic lymphocytic leukemia: results from the LRF CLL4 trial.
Morgan et al., London, United Kingdom. In J Clin Oncol, 2011
PATIENTS AND METHODS: We analyzed 529 CLL samples from the LRF CLL4 (Leukaemia Research Foundation Chronic Lymphocytic Leukemia 4) trial (chlorambucil v fludarabine with or without cyclophosphamide) at the time of random assignment for mutations in the TP53 gene.
Pokemon reduces Bcl-2 expression through NF-κ Bp65: A possible mechanism of hepatocellular carcinoma.
Tian et al., Wuhan, China. In Asian Pac J Trop Med, 2011
siRNA of Pokemon was applied to inhibit the expression of Pokemon and NF-kappa B p65 and apoptotic rate was determined by flow cytometric analysis
Depletion of Pokemon gene inhibits hepatocellular carcinoma cell growth through inhibition of H-ras.
Xu et al., Cangzhou, China. In Onkologie, 2010
Depletion of Pokemon inhibited proliferation of HepG(2) or induced apoptosis.
Prognosis after ipsilateral breast tumor recurrence and locoregional recurrences in patients treated by breast-conserving therapy in five National Surgical Adjuvant Breast and Bowel Project protocols of node-negative breast cancer.
Wolmark et al., Pittsburgh, United States. In J Clin Oncol, 2009
PURPOSE: Locoregional failure (LRF) after breast-conserving therapy (BCT) is associated with increased risk of distant disease and death.
Assessment of fludarabine plus cyclophosphamide for patients with chronic lymphocytic leukaemia (the LRF CLL4 Trial): a randomised controlled trial.
NCRI Chronic Lymphocytic Leukaemia Working Group et al., United Kingdom. In Lancet, 2007
BACKGROUND: Previous studies of patients with chronic lymphocytic leukaemia reported high response rates to fludarabine combined with cyclophosphamide.
Regulation of the p14ARF-Mdm2-p53 pathway: an overview in breast cancer.
Agrawal et al., Omaha, United States. In Exp Mol Pathol, 2006
In this review article factors including Pokemon, Geminin, Twist, and Apigenin, which control the action of individual proteins in the p14ARF-Mdm2-p53 pathway in breast cancer as well the consequences of mutation 7 of p53 are discussed.
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