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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Sortilin-related receptor, L

LR11, SorLA, SORL1, gp250
This gene encodes a mosaic protein that belongs to at least two families: the vacuolar protein sorting 10 (VPS10) domain-containing receptor family, and the low density lipoprotein receptor (LDLR) family. The encoded protein also contains fibronectin type III repeats and an epidermal growth factor repeat. The encoded protein is translated as a preproprotein and likely plays roles in endocytosis and sorting. There may be an association between expression of this locus and Alzheimer's Disease.[provided by RefSeq, Sep 2010] (from NCBI)
Top mentioned proteins: APP, apolipoprotein E, AGE, CAN, V1a
Papers on LR11
Embryonic exposure to 10 μg L(-1) lead results in female-specific expression changes in genes associated with nervous system development and function and Alzheimer's disease in aged adult zebrafish brain.
Freeman et al., West Lafayette, United States. In Metallomics, Feb 2016
In addition, alterations in genes associated with nervous system development and function were more pronounced with a set of 89 genes associated with AD including amyloid precursor protein (APP), apolipoprotein (APOE), and sortlin-related receptor precursor (SORL1) observed to be changed in adult females.
Enhanced genome editing in mammalian cells with a modified dual-fluorescent surrogate system.
Luo et al., Århus, Denmark. In Cell Mol Life Sci, Feb 2016
and 4.9 % when performing single- and double-gene targeting (MAPT and SORL1), respectively, in PPFs using C-Check-validated CRISPR/Cas9 vectors.
GWAS-Linked Loci and Neuroimaging Measures in Alzheimer's Disease.
Alzheimer’s Disease Neuroimaging Initiative et al., Qingdao, China. In Mol Neurobiol, Feb 2016
Meanwhile, rs11218343 at SORL1 and rs6733839 at BIN1 was associated with rate of volume change of left parahippocampal and right inferior parietal, respectively.
Soluble LR11 is a novel biomarker for vascular lesions late after Kawasaki disease.
Bujo et al., Niigata, Japan. In Atherosclerosis, Jan 2016
It is known that soluble LR11 (sLR11) is a novel biomarker for vascular lesions and LR11 is markedly expressed in intimal SMCs in atherosclerotic lesions.
Protein sorting gone wrong - VPS10P domain receptors in cardiovascular and metabolic diseases.
Willnow et al., Berlin, Germany. In Atherosclerosis, Jan 2016
In this review, we discuss current findings that uncovered some of the molecular mechanisms whereby sorting receptors, such as SORLA, sortilin, and SORCS1 control homeostasis in cardiovascular and metabolic tissues, and how they promote hypercholesterolemia, atherosclerosis, obesity, and diabetes, when being altered.
Microglial genes regulating neuroinflammation in the progression of Alzheimer's disease.
Pocock et al., London, United Kingdom. In Curr Opin Neurobiol, Nov 2015
The findings strongly implicate genes related to the immune response (CR1, CD33, MS4A, CLU, ABCA7, EPHA1 and HLA-DRB5-HLA-DRB1), endocytosis (BIN1, PICALM, CD2AP, EPHA1 and SORL1) and lipid biology (CLU, ABCA7 and SORL1) [2-8], and many encode proteins which are highly expressed in microglia [1].
Current and future implications of basic and translational research on amyloid-β peptide production and removal pathways.
St George-Hyslop et al., Toronto, Canada. In Mol Cell Neurosci, May 2015
Similarly, the more prevalent late-onset forms of AD are associated with both coding and non-coding variants in genes such as SORL1, PICALM and ABCA7 that affect the production and clearance of Aβ.
Dissecting risk haplotypes in sporadic Alzheimer's disease.
Jaenisch et al., Cambridge, United States. In Cell Stem Cell, May 2015
In this issue of Cell Stem Cell, Young et al. (2015) dissect the function of common non-coding risk haplotypes in the SORL1 locus in the pathogenesis of sporadic Alzheimer's disease using patient-derived induced pluripotent stem cells.
Elucidating molecular phenotypes caused by the SORL1 Alzheimer's disease genetic risk factor using human induced pluripotent stem cells.
Goldstein et al., San Diego, United States. In Cell Stem Cell, May 2015
Here we used hIPSCs to examine genetic variation in the SORL1 gene and possible contributions to SAD-related phenotypes in human neurons.
Alzheimer's disease risk genes and mechanisms of disease pathogenesis.
Goate et al., Saint Louis, United States. In Biol Psychiatry, 2015
More recent advances in understanding of the human genome-technologic advances in methods to analyze millions of polymorphisms in thousands of subjects-have revealed new genes associated with AD risk, including ABCA7, BIN1, CASS4, CD33, CD2AP, CELF1, CLU, CR1, DSG2, EPHA1, FERMT2, HLA-DRB5-DBR1, INPP5D, MS4A, MEF2C, NME8, PICALM, PTK2B, SLC24H4-RIN3, SORL1, and ZCWPW1.
Genetics of Alzheimer's disease.
Seshadri et al., Boston, United States. In Adv Genet, 2013
Then, we will explore linkage analysis and candidate gene approaches, which identified variants in Apolipoprotein E (APOE) as the major genetic risk factor for late-onset, "sporadic" forms of AD (LOAD), but failed to robustly identify other genetic risk factors, with the exception of variants in SORL1.
Association of SORL1 alleles with late-onset Alzheimer's disease. findings from the GIGAS_LOAD study and mega-analysis.
Serretti et al., Bologna, Italy. In Curr Alzheimer Res, 2012
The results of this study suggested that no association was detected between SORL1 genotypes and late-onset Alzheimer's disease.
Characterization of Intestinal Lactobacillus reuteri Strains as Potential Probiotics.
Kapila et al., Karnāl, India. In Probiotics Antimicrob Proteins, 2012
LR5, LR6, LR9, LR11, LR19, LR20, LR25, LR26 and LR34) showed survival in acid, bile and simulated stomach-duodenum passage conditions, indicating their high tolerance to gastric juice, duodenal juice and bile environments.
Retromer binds the FANSHY sorting motif in SorLA to regulate amyloid precursor protein sorting and processing.
Andersen et al., Århus, Denmark. In J Neurosci, 2012
A sequence (FANSHY) in the cytoplasmic domain of sorLA and the retromer complex functionally interacts in neurons to control trafficking and amyloidogenic processing of amyloid precursor protein (APP).
Quantitative modelling of amyloidogenic processing and its influence by SORLA in Alzheimer's disease.
Willnow et al., Berlin, Germany. In Embo J, 2012
Minimal decline in SORLA activity contributes to amyloidogenic processing.
Sorting protein-related receptor SorLA controls regulated secretion of glial cell line-derived neurotrophic factor.
Chen et al., Jinan, China. In J Biol Chem, 2012
overexpression of SorLA could enhance the regulated secretion of the GDNF prodomain-GFP fusion protein, suggesting that the prodomain of GDNF is responsible for its regulated secretion.
Impact of SORL1 single nucleotide polymorphisms on Alzheimer's disease cerebrospinal fluid markers.
Perneczky et al., München, Germany. In Dement Geriatr Cogn Disord, 2010
SORL1 genetic variants are related to Alzheimer's disease pathology
An endogenous peptide positively selects and augments the activation and survival of peripheral CD4+ T cells.
Allen et al., Saint Louis, United States. In Nat Immunol, 2009
One peptide, gp250, induced positive selection of AND CD4(+) T cells, had no homology with the AND TCR agonist ligand and was recognized with a high degree of specificity.
VPS10P-domain receptors - regulators of neuronal viability and function.
Nykjaer et al., Berlin, Germany. In Nat Rev Neurosci, 2008
VPS10P-domain receptors, such as SORLA and sortilin, constitute a recently identified class of type-1 receptors that are expressed in neurons.
The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease.
St George-Hyslop et al., Toronto, Canada. In Nat Genet, 2007
We report here that inherited variants in the SORL1 neuronal sorting receptor are associated with late-onset Alzheimer disease
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