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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Phosphatidic acid phosphatase type 2C

LPP2, Ppap2c, AtLPP2, PAP-2c, hPAP2c
The protein encoded by this gene is a member of the phosphatidic acid phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in de novo synthesis of glycerolipids as well as in receptor-activated signal transduction mediated by phospholipase D. This protein is similar to phosphatidic acid phosphatase type 2A (PPAP2A) and type 2B (PPAP2B). All three proteins contain 6 transmembrane regions, and a consensus N-glycosylation site. This protein has been shown to possess membrane associated PAP activity. Three alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008] (from NCBI)
Papers on LPP2
Arabidopsis thaliana lipid phosphate phosphatase 2 is involved in abscisic acid signalling in leaves.
GeneRIF
Jeannette et al., Paris, France. In Plant Physiol Biochem, 2011
Taken together our observations show that AtLPP2 is a part of ABA signalling and participate to the regulation of stomatal movements.
Lipid phosphate phosphatases form homo- and hetero-oligomers: catalytic competency, subcellular distribution and function.
GeneRIF
Pyne et al., Glasgow, United Kingdom. In Biochem J, 2008
endogenous LPP2 and LPP3 form homo- and hetero-oligomers, which differ in their subcellular localization and which may confer differing spatial regulation of phosphatidic acid and sphingosine 1-phosphate signalling
Lipid phosphate phosphatase-2 activity regulates S-phase entry of the cell cycle in Rat2 fibroblasts.
GeneRIF
Brindley et al., Edmonton, Canada. In J Biol Chem, 2006
identified a novel and specific role for LPP2 activity and bioactive lipids in regulating cell cycle progression
An important role of phosphatidic acid in ABA signaling during germination in Arabidopsis thaliana.
GeneRIF
Shinozaki et al., Tsukuba, Japan. In Plant J, 2005
Two AtLPP2 T-DNA insertional mutants (lpp2-1 and lpp2-2) showed hypersensitivity to ABA and significant PA accumulation during germination. [AtLPP2]
Mice mutant for Ppap2c, a homolog of the germ cell migration regulator wunen, are viable and fertile.
GeneRIF
Gridley et al., Bar Harbor, United States. In Genesis, 2000
Functional study of the mouse homolog
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