Lipid phosphate phosphatases and lipid phosphate signalling.
Glasgow, United Kingdom. In Biochem Soc Trans, 2005
However, our recent work suggests that an intracellular action of LPP2 and LPP3 may account for the reduced agonist-stimulated p42/p44 mitogen-activated protein kinase activation of HEK-293 (human embryonic kidney 293) cells.
Lysophosphatidic acid and sphingosine 1-phosphate biology: the role of lipid phosphate phosphatases.
Glasgow, United Kingdom. In Semin Cell Dev Biol, 2004
The biological actions of the lysolipid agonists sphingosine 1-phosphate and lysophosphatidic acid, in addition to other bioactive lipid phosphates such as phosphatidic acid and ceramide 1-phosphate, can be influenced by a family of lipid phosphate phosphatases (LPP), including LPP1, LPP2, LPP3, the Drosophila homologues Wunen (Wun) and Wunen2 (Wun2) and sphingosine 1-phosphate phosphatases 1 and 2 (SPP1, SPP2).