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LIM domain containing preferred translocation partner in lipoma

This gene encodes a member of a subfamily of LIM domain proteins that are characterized by an N-terminal proline rich region and three C-terminal LIM domains. The encoded protein localizes to the cell periphery in focal adhesions and may be involved in cell-cell adhesion and cell motility. This protein also shuttles through the nucleus and may function as a transcriptional co-activator. This gene is located at the junction of certain disease related chromosomal translocations which result in the expression of chimeric proteins that may promote tumor growth. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010] (from NCBI)
Top mentioned proteins: CAN, ACID, HAD, V1a, LIM
Papers on LPP
Impaired cognitive reappraisal in panic disorder revealed by the late positive potential.
Tang et al., Dalian, China. In Neuroreport, Feb 2016
The late positive potential (LPP), an event-related potential component sensitive to cognitive change strategies, was examined as an index of cognitive reappraisal.
Adipose-derived stem cells seeded on polyglycolic acid for the treatment of stress urinary incontinence.
Fu et al., Shanghai, China. In World J Urol, Feb 2016
Two months after implantation, the mean leak point pressure (LPP) was significantly increased in sling-treated rats compared with the balloon-injured ovariectomized rats.
Insulin-like growth factor-1 as an important endogenous growth factor for the recovery from impaired urethral continence function in rats with simulated childbirth injury.
Yoshimura et al., Pittsburgh, United States. In J Urol, Feb 2016
At 7, 14 and 21 days after VD, the effect of JB-1 treatment was examined by functional analyses (leak point pressure; LPP, urethral baseline pressure; UBP and urethral responses during passive increments in intravesical pressure) and molecular analyses in urethral tissues (phosphorylation of Akt, apoptotic changes and peripheral nerve density using Western blotting and immunohistochemistry).
MicroRNA 28-5p regulates ATP-binding cassette transporter A1 via inhibiting extracellular signal-regulated kinase 2.
Zhou et al., Shijiazhuang, China. In Mol Med Report, Jan 2016
The biological function of the intronic microRNA-28 (miR-28) may be associated with the biological roles of its host gene, LIM domain lipoma‑preferred partner (LPP).
Motivational engagement in Parkinson's disease: Preparation for motivated action.
Bowers et al., Gainesville, United States. In Int J Psychophysiol, Jan 2016
The study measured an electrocortical correlate of preparation for action (CNV amplitude) in PD patients and healthy controls, as well as defensive and appetitive activation during emotional perception (LPP amplitude).
On dissociating the neural time course of the processing of positive emotions.
Puce et al., Bloomington, United States. In Neuropsychologia, Jan 2016
Moreover, main effects of Task were found for the VPP, P250, LPP and SPW; additionally, Emotion X Task interactions were observed for P250 and SPW.
The Effect of Affective Context on Visuocortical Processing of Neutral Faces in Social Anxiety.
Moscovitch et al., Würzburg, Germany. In Front Psychol, 2014
Moreover, HSA compared to LSA showed enhanced late positive potentials (LPP) to negatively contextualized faces, whereas in LSA this effect was found for faces in positive contexts.
Treatment of frontal fibrosing alopecia and lichen planopilaris: a systematic review.
Neumann et al., Rotterdam, Netherlands. In J Eur Acad Dermatol Venereol, 2013
FFA is considered a subtype of lichen planopilaris (LPP), based on their identical histopathology.
Genome-wide association study of B cell non-Hodgkin lymphoma identifies 3q27 as a susceptibility locus in the Chinese population.
Liu et al., Singapore, Singapore. In Nat Genet, 2013
We identified a new susceptibility locus, rs6773854, located between BCL6 (encoding B cell lymphoma protein 6) and LPP (encoding lipoma preferred partner) on oncogene-rich chromosome 3q27 that was significantly associated with increased risk of B cell NHL (meta-analysis P = 3.36 × 10⁻¹³, per-allele odds ratio (OR) = 1.44) and with diffuse large B cell lymphoma (DLBCL) in particular (meta-analysis P = 1.14 × 10⁻¹¹, OR = 1.47).
Current views on regulation and function of plasticity-related genes (PRGs/LPPRs) in the brain.
Bräuer et al., Berlin, Germany. In Biochim Biophys Acta, 2013
Plasticity-related genes (PRGs, Lipid phosphate phosphatase-related proteins LPPRs) are a defined as a subclass of the lipid phosphate phosphatase (LPP) superfamily, comprising so far five brain- and vertebrate-specific membrane-spanning proteins.
Role of the autotaxin-lysophosphatidate axis in cancer resistance to chemotherapy and radiotherapy.
Tigyi et al., Edmonton, Canada. In Biochim Biophys Acta, 2013
The signaling actions of extracellular LPA are terminated by its dephosphorylation by a family of lipid phosphate phosphatases (LPP) that act as ecto-enzymes.
Lipid phosphate phosphatase (LPP3) and vascular development.
Smyth et al., Lexington, United States. In Biochim Biophys Acta, 2013
Lipid phosphate phosphatases (LPP) are integral membrane proteins with broad substrate specificity that dephosphorylate lipid substrates including phosphatidic acid, lysophosphatidic acid, ceramide 1-phosphate, sphingosine 1-phosphate, and diacylglycerol pyrophosphate.
Mitochondria as a source and target of lipid peroxidation products in healthy and diseased heart.
Willis et al., Chapel Hill, United States. In Clin Exp Pharmacol Physiol, 2012
The heart is a highly oxidative organ in which cardiomyocyte turnover is virtually absent, making it particularly vulnerable to accumulation of lipid peroxidation products (LPP) formed as a result of oxidative damage.
Identification of IL6R and chromosome 11q13.5 as risk loci for asthma.
Australian Asthma Genetics Consortium et al., Brisbane, Australia. In Lancet, 2011
Multi-marker association results are consistent with a highly polygenic contribution to asthma risk, including loci with weak effects that might be shared with other immune-related diseases, such as NDFIP1, HLA-B, LPP, and BACH2.
Haploinsufficiency of the LIM domain containing preferred translocation partner in lipoma (LPP) gene in patients with tetralogy of Fallot and VACTERL association.
Bowles et al., Salt Lake City, United States. In Am J Med Genet A, 2010
haploinsufficiency of LPP may be a novel cause of conotruncal cardiac anomalies, particularly forms of tetralogy of Fallot
Cell Adhesion and Transcriptional Activity - Defining the Role of the Novel Protooncogene LPP.
Butt et al., München, Germany. In Transl Oncol, 2009
LPP is a nucleocytoplasmatic shuttle protein linking focal adhesion dynamics to the transcriptional machinery.
Targeted disruption of the mouse Lipoma Preferred Partner gene.
Petit et al., Leuven, Belgium. In Biochem Biophys Res Commun, 2009
Mice with a targeted disruption of the Lpp gene were generated, and the importance of Lpp for embryonic development and adult functions was analysed.
[Expressions of bcl-6, lpp and miR-28 genes in diffuse large B cell lymphoma cell lines].
Shen et al., Nanjing, China. In Zhongguo Shi Yan Xue Ye Xue Za Zhi, 2009
Gene expression levels of bcl-6, lpp and miR-28 are different in various diffuse large B cell lymphoma cell lines.
Mechanical properties of the extracellular matrix alter expression of smooth muscle protein LPP and its partner palladin; relationship to early atherosclerosis and vascular injury.
Somlyo et al., Charlottesville, United States. In J Muscle Res Cell Motil, 2008
expression of LPP and palladin are modulated by a mix of mechanical cues, oxidative stress and substrate composition which translate into their up or down regulation in vessel wall injury and early atherogenesis.
Cytophaga that kills or lyses algae.
Brown et al., In Science, 1969
When assayed with Nostoc muscorum or Plectonema boryanum, plaques form like those caused by the blue-green algal virus LPP-1.
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