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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Lysophosphatidic acid receptor 4

LPA4, GPR23, P2Y9
This gene encodes a member of the lysophosphatidic acid receptor family. It may also be related to the P2Y receptors, a family of receptors that bind purine and pyrimidine nucleotides and are coupled to G proteins. The encoded protein may play a role in monocytic differentiation. [provided by RefSeq, Feb 2009] (from NCBI)
Top mentioned proteins: ACID, LpA-I, GPCR, GPR92, G protein-coupled receptor
Papers on LPA4
Lysophosphatidic acid receptors LPA4 and LPA6 differentially promote lymphocyte transmigration across high endothelial venules in lymph nodes.
New
Miyasaka et al., Suita, Japan. In Int Immunol, Jan 2016
Here, we show that two LPA receptors, LPA4 and LPA6, are selectively expressed on HEV endothelial cells (ECs) and that LPA4 plays a major role in the lymphocyte transmigration across HEVs in mice.
Diverse effects of LPA4, LPA5 and LPA6 on the activation of tumor progression in pancreatic cancer cells.
New
Tsujiuchi et al., Ōsaka, Japan. In Biochem Biophys Res Commun, Jun 2015
In the present study, to assess the roles of LPA4, LPA5 and LPA6 in cellular functions of pancreatic cancer cells, we generated LPA receptor knockdown cells from PANC-1 cells (PANC-sh4, PANC-sh5 and PANC-sh6 cells, respectively).
The lysophosphatidic acid receptor LPA4 regulates hematopoiesis-supporting activity of bone marrow stromal cells.
Ishii et al., Akita, Japan. In Sci Rep, 2014
Although several biological roles of LPA4 are becoming apparent, its role in hematopoiesis has remained unknown.
The autotaxin-lysophosphatidic acid-lysophosphatidic acid receptor cascade: proposal of a novel potential therapeutic target for treating glioblastoma multiforme.
Review
Tabuchi, Tottori, Japan. In Lipids Health Dis, 2014
LPA1 is responsible for LPA-driven cell motility, which is attenuated by LPA4.
Expression of lysophosphatidic acid receptors in the human lower esophageal sphincter.
Liu et al., Shijiazhuang, China. In Exp Ther Med, 2014
It acts via six distinct types of receptors, LPA1, LPA2, LPA3, LPA4, LPA5 and LPA6, which belong to the family of G protein-coupled receptors.
Lysophosphatidic acid induces vasodilation mediated by LPA1 receptors, phospholipase C, and endothelial nitric oxide synthase.
Benyó et al., Budapest, Hungary. In Faseb J, 2014
Freshly isolated mouse aortic endothelial cells expressed LPA1, LPA2, LPA4 and LPA5 transcripts.
Autotaxin as a novel, tissue-remodeling-related factor in regressing corpora lutea of cycling rats.
Kurusu et al., Japan. In Febs J, 2013
Among the LPA receptors examined (LPA1-4 ), LPA4 was densely present on migratory cells, probably phagocytes, at degenerative foci within regressing CL.
International Union of Basic and Clinical Pharmacology. LXXXVIII. G protein-coupled receptor list: recommendations for new pairings with cognate ligands.
Review
Impact
Harmar et al., Cambridge, United Kingdom. In Pharmacol Rev, 2013
The following recommendations are made for new receptor names based on 11 pairings for class A GPCRs: hydroxycarboxylic acid receptors [HCA₁ (GPR81) with lactate, HCA₂ (GPR109A) with 3-hydroxybutyric acid, HCA₃ (GPR109B) with 3-hydroxyoctanoic acid]; lysophosphatidic acid receptors [LPA₄ (GPR23), LPA₅ (GPR92), LPA₆ (P2Y5)]; free fatty acid receptors [FFA4 (GPR120) with omega-3 fatty acids]; chemerin receptor (CMKLR1; ChemR23) with chemerin; CXCR7 (CMKOR1) with chemokines CXCL12 (SDF-1) and CXCL11 (ITAC); succinate receptor (SUCNR1) with succinate; and oxoglutarate receptor [OXGR1 with 2-oxoglutarate].
Lysophosphatidic acid receptor 4 signaling potentially modulates malignant behavior in human head and neck squamous cell carcinoma cells.
Kato et al., Okinawa, Japan. In Int J Oncol, 2013
LPAs activate G-protein-coupled receptors not only in the endothelial differentiation gene (Edg) family (LPA1, LPA2, LPA3) but also in the phylogenetically distant non-Edg family (LPA4, LPA5, LPA6).
Comparing the differential effects of LPA on the barrier function of human pulmonary endothelial cells.
Budd et al., Nutley, United States. In Microvasc Res, 2013
HPAECs also exhibit low expression of LPA1, LPA3, and LPA4 receptor subtypes.
Gintonin, newly identified compounds from ginseng, is novel lysophosphatidic acids-protein complexes and activates G protein-coupled lysophosphatidic acid receptors with high affinity.
Nah et al., Seoul, South Korea. In Mol Cells, 2012
Gintonin induced [Ca2+]i transients in B103 rat neuroblastoma cells transfected with human LPA receptors with high affinity in order of LPA2 >LPA5 > LPA1 > LPA3 > LPA4.
Non-Edg family LPA receptors: the cutting edge of LPA research.
Review
Ishii et al., Tokyo, Japan. In J Biochem, 2011
Originally, LPA was thought to elicit its biological functions through three subtypes of endothelial differentiation gene (Edg) family G protein-coupled receptors (LPA1, LPA2 and LPA3) until our group identified a fourth subtype, LPA4.
LPA4 regulates blood and lymphatic vessel formation during mouse embryogenesis.
GeneRIF
Ishii et al., Tokyo, Japan. In Blood, 2011
These results suggest that LPA(4) regulates establishment of the structure and function of blood and lymphatic vessels during mouse embryogenesis
Differential expressions and DNA methylation patterns of lysophosphatidic acid receptor genes in human colon cancer cells.
GeneRIF
Tsujiuchi et al., Ōsaka, Japan. In Virchows Arch, 2010
LPA4 gene mutation may play some role in the pathogenesis of colon cancer.
LPA(3), a unique G protein-coupled receptor for lysophosphatidic acid.
Review
Aoki et al., Sendai, Japan. In Prog Lipid Res, 2010
So far, six GPCRs for LPA have been identified: LPA(1)/Edg2, LPA(2)/Edg4, LPA(3)/Edg7, LPA(4)/GPR23/P2Y9, LPA(5)/GPR92 and LPA(6)/P2Y5.
LPA induces osteoblast differentiation through interplay of two receptors: LPA1 and LPA4.
GeneRIF
Billiard et al., United States. In J Cell Biochem, 2010
LPA4 and LPA5 receptors induce osteoblastic differentiation of human mesenchymal stem cells
Lysophosphatidic acid receptor expression in chronic lymphocytic leukemia leads to cell survival mediated though vascular endothelial growth factor expression.
GeneRIF
Gibson et al., Winnipeg, Canada. In Leuk Lymphoma, 2009
Data show that CLL cells express LPA receptors LPA(1-5) and VEGF receptors, and the plasma levels of VEGF are elevated in CLL patients.
Non-Edg family lysophosphatidic acid (LPA) receptors.
Review
Yanagida et al., Tokyo, Japan. In Prostaglandins Other Lipid Mediat, 2009
In 2003, we identified p2y9/GPR23 as a fourth LPA receptor, LPA(4), which is structurally distant from the Edg family LPA receptors.
Role of LPA4/p2y9/GPR23 in negative regulation of cell motility.
GeneRIF
Fang et al., Richmond, United States. In Mol Biol Cell, 2008
These results provide genetic and biochemical evidence that LPA(4) is a suppressor of LPA-dependent cell migration and invasion in contrast to the motility-stimulating Edg LPA receptors.
G protein-coupled receptor P2Y5 and its ligand LPA are involved in maintenance of human hair growth.
Impact
Betz et al., Bonn, Germany. In Nat Genet, 2008
Homology and studies of signaling transduction pathways suggest that P2Y5 is a member of a subgroup of LPA receptors, which also includes LPA4 and LPA5.
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