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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Lysophosphatidic acid receptor 1

LpA-I, LPA1, LPA receptor, Edg-2, lysophosphatidic acid receptor
The integral membrane protein encoded by this gene is a lysophosphatidic acid (LPA) receptor from a group known as EDG receptors. These receptors are members of the G protein-coupled receptor superfamily. Utilized by LPA for cell signaling, EDG receptors mediate diverse biologic functions, including proliferation, platelet aggregation, smooth muscle contraction, inhibition of neuroblastoma cell differentiation, chemotaxis, and tumor cell invasion. Two transcript variants encoding the same protein have been identified for this gene [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, V1a, GPCR, HDL, CAN
Papers on LpA-I
Lysophosphatidic acid upregulates connective tissue growth factor expression in osteoblasts through the GPCR/PKC and PKA pathways.
New
Li et al., Wuhan, China. In Int J Mol Med, Feb 2016
LPA receptor1/3 was inhibited by Ki16425, a specific inhibitor of LPA1/3; as a result, the LPA-induced increase in CCN2 expression was abrogated.
Rapid remodeling of invadosomes by Gi-coupled receptors: dissecting the role of Rho GTPases.
New
Moolenaar et al., Netherlands. In J Biol Chem, Feb 2016
Here we show that Src-induced invadosomes in melanoma cells undergo rapid remodeling into dynamic ECM-degrading rosettes by distinct G protein-coupled receptor (GPCR) agonists, notably lysophosphatidic acid (LPA, acting through the LPA1 receptor) and endothelin.
Gintonin enhances performance of mice in rotarod test: involvement of lysophosphatidic acid receptors and catecholamine release.
New
Nah et al., Seoul, South Korea. In Neurosci Lett, Jan 2016
This elevation in blood glucose level could be abrogated by the LPA1/3 receptor antagonist, Ki16425, or the β-adrenergic receptor antagonist, propranolol.
Both genetic deletion and pharmacological blockade of lysophosphatidic acid LPA1 receptor results in increased alcohol consumption.
New
Serrano et al., Málaga, Spain. In Neuropharmacology, Jan 2016
The present study investigates the consequences of either genetic deletion or pharmacological blockade of lysophosphatidic acid receptor-1 (LPA1) in alcohol consumption.
Systemic sclerosis: from pathogenesis to targeted therapy.
Review
New
Denton, London, United Kingdom. In Clin Exp Rheumatol, Jul 2015
Promising results are emerging from targeting cytokine signalling, including IL-6, and from other immune-inflammatory therapies including lipid mediators such as LPA1.
Crystal Structure of Antagonist Bound Human Lysophosphatidic Acid Receptor 1.
New
Impact
Hanson et al., San Diego, United States. In Cell, Jul 2015
Structural analysis combined with molecular dynamics identified a basis for ligand access to the LPA1 binding pocket from the extracellular space contrasting with the proposed access for the sphingosine 1-phosphate receptor.
Comparative analyses of lysophosphatidic acid receptor-mediated signaling.
Review
New
Katoh et al., Japan. In Cell Mol Life Sci, Jun 2015
Six LPA receptor genes have been identified in vertebrates and are classified into two subfamilies, the endothelial differentiation genes (edg) and the non-edg family.
Ginseng pharmacology: a new paradigm based on gintonin-lysophosphatidic acid receptor interactions.
Review
Nah et al., Seoul, South Korea. In Front Pharmacol, 2014
This review article introduces a novel concept of ginseng ligand-LPA receptor interaction and proposes to establish a paradigm that shifts the focus from ginsenosides to gintonin as a major ingredient representing ginseng pharmacology.
The autotaxin-lysophosphatidic acid-lysophosphatidic acid receptor cascade: proposal of a novel potential therapeutic target for treating glioblastoma multiforme.
Review
Tabuchi, Tottori, Japan. In Lipids Health Dis, 2014
As the bioactive multifunctional lipid mediator lysophosphatidic acid (LPA) is well recognized to be involved in the tumorigenesis of cancers by acting on G-protein-coupled receptors, LPA receptor (LPAR) antagonists and LPA synthesis inhibitors have been proposed as promising drugs for cancer treatment.
Autotaxin-LPA receptor axis in the pathogenesis of lung diseases.
Review
He et al., Rizhao, China. In Int J Clin Exp Med, 2014
Here, we briefly review the current knowledge of different roles of the ATX-LPA receptor axis in lung diseases focusing on inflammation, fibrosis and cancer.
Expressions of lysophosphatidic acid receptors in the development of human ovarian carcinoma.
Tang et al., Guangzhou, China. In Int J Clin Exp Med, 2014
AIM: To investigate the associations between the expressions of three lysophosphatidic acid (LPA) receptors (LPA1-3) and the development of ovarian carcinoma (OC).
LPA-induced suppression of periostin in human osteosarcoma cells is mediated by the LPA(1)/Egr-1 axis.
GeneRIF
Malle et al., Graz, Austria. In Biochimie, 2012
a crosslink between Egr-1 and periostin in cancer cells
Hippocampal c-Fos activation in normal and LPA₁-null mice after two object recognition tasks with different memory demands.
GeneRIF
Santín et al., Málaga, Spain. In Behav Brain Res, 2012
LPA(1)-null mice displayed a basal c-Fos hyperactivity in the hippocampus and in the medial prefrontal cortex, which was regulated differently by the two different memory tasks employed.
Enhancement of endothelial cell migration by constitutively active LPA(1)-expressing tumor cells.
GeneRIF
Tsujiuchi et al., Ōsaka, Japan. In Biochem Biophys Res Commun, 2012
These results suggest that activation of LPA signaling via mutated LPA(1) may play an important role in the promotion of angiogenesis in rat neuroblastoma cells.
The lysophosphatidic acid receptor LPA1 promotes epithelial cell apoptosis after lung injury.
GeneRIF
Tager et al., United States. In Am J Respir Cell Mol Biol, 2012
The ability of LPA-LPA(1) signaling to promote epithelial cell apoptosis and fibroblast resistance to apoptosis may therefore contribute to the capacity of this signaling pathway to regulate the development of pulmonary fibrosis after lung injury.
Constitutively active lysophosphatidic acid receptor-1 enhances the induction of matrix metalloproteinase-2.
GeneRIF
Tsujiuchi et al., Ōsaka, Japan. In Biochem Biophys Res Commun, 2012
These results suggest that mutated LPA(1) may involve in the enhancement of Mmp-2 expression and activation in rat neuroblastoma cells.
Mammary tumorigenesis through LPA receptor signaling.
Impact
Moolenaar et al., Amsterdam, Netherlands. In Cancer Cell, 2009
Lysophosphatidic acid (LPA) is a lipid growth factor that is produced by an extracellular phospholipase, termed autotaxin (ATX), and acts via G protein-coupled receptors.
Expression of autotaxin and lysophosphatidic acid receptors increases mammary tumorigenesis, invasion, and metastases.
Impact
Mills et al., Houston, United States. In Cancer Cell, 2009
We demonstrate that expression of ATX or each edg family LPA receptor in mammary epithelium of transgenic mice is sufficient to induce a high frequency of late-onset, estrogen receptor (ER)-positive, invasive, and metastatic mammary cancer.
The lysophosphatidic acid receptor LPA1 links pulmonary fibrosis to lung injury by mediating fibroblast recruitment and vascular leak.
Impact
GeneRIF
Luster et al., United States. In Nat Med, 2008
LPA1 links pulmonary fibrosis to lung injury by mediating fibroblast recruitment and vascular leak
Embryo-specific silencing of a transporter reduces phytic acid content of maize and soybean seeds.
Impact
Glassman et al., United States. In Nat Biotechnol, 2007
We show that maize lpa1 mutants are defective in a multidrug resistance-associated protein (MRP) ATP-binding cassette (ABC) transporter that is expressed most highly in embryos, but also in immature endosperm, germinating seed and vegetative tissues.
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