gopubmed logo
 
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Lysyl oxidase-like 2

LOXL2, LOXL3, lysyl oxidase-like 2
This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: lysyl oxidase, elastin, Lol, LOXL4, CAN
Papers on LOXL2
Tumor-suppressive microRNA-29 family inhibits cancer cell migration and invasion directly targeting LOXL2 in lung squamous cell carcinoma.
New
Inoue et al., Kagoshima, Japan. In Int J Oncol, Feb 2016
Gene expression data combined in silico analysis and luciferase reporter assays demonstrated that the lysyl oxidase-like 2 (LOXL2) gene was a direct regulator of tumor‑suppressive miR‑29s.
Comparative Characterization of Vaginal Cells Derived From Premenopausal Women With and Without Severe Pelvic Organ Prolapse.
New
Shynlova et al., Toronto, Canada. In Reprod Sci, Feb 2016
Collagen XV and tissue inhibitors of MMPs (TIMP1 and TIMP2) as well as genes involved in the biogenesis and maturation of collagen and elastin fibers (LOX, LOXL1-LOXL3, BMP1, and ADAMTS2) were significantly downregulated in POP-HVCs versus control-HVCs (P < .05).
Is Western Diet-Induced Nonalcoholic Steatohepatitis in Ldlr-/- Mice Reversible?
New
Jump et al., Corvallis, United States. In Plos One, Dec 2015
Returning WD-fed mice to the NP or LFLC diets significantly reduced body weight and plasma markers of metabolic syndrome (dyslipidemia, hyperglycemia) and hepatic gene expression markers of inflammation (Mcp1), oxidative stress (Nox2), fibrosis (Col1A, LoxL2, Timp1) and collagen crosslinking (hydroxyproline).
Lysyl oxidase modulates the osteoblast differentiation of primary mouse calvaria cells.
New
Kim et al., Iksan, South Korea. In Int J Mol Med, Dec 2015
Thus far, five LOX family genes [LOX, lysyl oxidase-like (LOXL)1, LOXL2, LOXL3 and LOXL4] have been identified in humans, each encoding the characteristic C-terminal domains that are required for amine oxidase activity.
Exosomes from hypoxic endothelial cells have increased collagen crosslinking activity through up-regulation of lysyl oxidase-like 2.
New
Verhaar et al., Utrecht, Netherlands. In J Cell Mol Med, Dec 2015
Here, we investigate whether the exosome-associated lysyl oxidase family member lysyl oxidase-like 2 (LOXL2) is involved in ECM remodelling.
Loss of lysyl oxidase-like 3 causes cleft palate and spinal deformity in mice.
New
Gao et al., Jinan, China. In Hum Mol Genet, Dec 2015
In this study, we investigated the essential role of lysyl oxidase-like 3 (LOXL3), a member of the LOX family, in embryonic development.
The function and mechanisms of action of LOXL2 in cancer (Review).
New
Zhu et al., Dalian, China. In Int J Mol Med, Nov 2015
Among these, at present, LOX‑like (LOXL)2 is the prototypical LOX and the most comprehensively studied member.
Tumor-suppressive microRNAs (miR-26a/b, miR-29a/b/c and miR-218) concertedly suppressed metastasis-promoting LOXL2 in head and neck squamous cell carcinoma.
New
Seki et al., Chiba, Japan. In J Hum Genet, Nov 2015
These tumor-suppressive miRNAs directly regulate LOXL2 expression in HNSCC cells by using in silico analysis and luciferase reporter assays.
A new role for LOX and LOXL2 proteins in transcription regulation.
Review
New
Peiró et al., Barcelona, Spain. In Febs J, May 2015
However, recent findings suggest a critical intracellular role for LOX and LOXL2 in transcriptional regulation.
Human lysyl oxidase-like 2.
Review
Mure et al., Lawrence, United States. In Bioorg Chem, 2014
Lysyl oxidase like-2 (LOXL2) belongs to the lysyl oxidase (LOX) family, which comprises Cu(2+)- and lysine tyrosylquinone (LTQ)-dependent amine oxidases.
Identifying specific proteins involved in eggshell membrane formation using gene expression analysis and bioinformatics.
Gautron et al., Ottawa, Canada. In Bmc Genomics, 2014
Genes encoding collagen-processing enzymes such as lysyl oxidase homologs 1, 2 and 3 (LOXL1, LOXL2 and LOXL3), prolyl 4 hydroxylase subunit α-2 and beta polypeptide (P4HA2 and P4HB) as well as peptidyl-prolyl cis-trans isomerase C (PPIC) were also over-expressed.
Genomic and molecular aberrations in malignant peripheral nerve sheath tumor and their roles in personalized target therapy.
Review
Du et al., Tianjin, China. In Surg Oncol, 2013
The involved genes in the significant gains aberrations include BIRC5, CCNE2, DAB2, DDX15, EGFR, DAB2, MSH2, CDK6, HGF, ITGB4, KCNK12, LAMA3, LOXL2, MET, and PDGFRA.
LOXL2 in epithelial cell plasticity and tumor progression.
Review
Moreno-Bueno et al., Madrid, Spain. In Future Oncol, 2012
Among them, LOXL2 has been shown to be involved in tumor progression and metastasis of several tumor types, including breast carcinomas.
Molecular mechanisms mediating metastasis of hypoxic breast cancer cells.
Review
Semenza, Baltimore, United States. In Trends Mol Med, 2012
Recently, HIFs have been shown to play critical roles in the metastasis of breast cancer to the lungs through the transcriptional activation of genes encoding angiopoietin-like 4 and L1 cell adhesion molecule, which promote the extravasation of circulating cancer cells from the lung vasculature, and the lysyl oxidase family members LOX, LOXL2, and LOXL4, which promote invasion and metastatic niche formation.
Reduced nuclear and ectopic cytoplasmic expression of lysyl oxidase-like 2 is associated with lymph node metastasis and poor prognosis in esophageal squamous cell carcinoma.
GeneRIF
Li et al., Shantou, China. In Hum Pathol, 2012
These results suggest that lysyl oxidase L2 exerts a critical effect on esophageal squamous cell carcinoma progression and can be a predictive marker of lymph node metastasis and outcome.
Lysyl oxidase-like 2 deaminates lysine 4 in histone H3.
GeneRIF
Peiró et al., Barcelona, Spain. In Mol Cell, 2012
LOXL2 activity is linked with the transcriptional control of CDH1 gene by regulating H3K4me3 deamination.
The enzymatic activity of lysyl oxidas-like-2 (LOXL2) is not required for LOXL2-induced inhibition of keratinocyte differentiation.
GeneRIF
Neufeld et al., Haifa, Israel. In J Biol Chem, 2012
The enzymatic activity of lysyl oxidas-like-2 (LOXL2) is not required for LOXL2-induced inhibition of keratinocyte differentiation.
Lysyl oxidase-like protein-2 regulates sprouting angiogenesis and type IV collagen assembly in the endothelial basement membrane.
GeneRIF
Germain et al., Paris, France. In Blood, 2011
This study provides the first evidence for the role of LOXL2 in regulating angiogenesis through collagen IV scaffolding.
Common polymorphisms in human lysyl oxidase genes are not associated with the adolescent idiopathic scoliosis phenotype.
GeneRIF
Muglia et al., Nashville, United States. In Bmc Med Genet, 2010
The human lysyl oxidase-like 3 gene does not confer increased genotypic risk for adolescent idiopathic scoliosis.
Allosteric inhibition of lysyl oxidase-like-2 impedes the development of a pathologic microenvironment.
Impact
GeneRIF
Smith et al., Palo Alto, United States. In Nat Med, 2010
The efficacy and safety of LOXL2-specific monoclonal antibody represents a new therapeutic approach with broad applicability in oncologic and fibrotic diseases.
share on facebooktweetadd +1mail to friends