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Loricrin

LOR, Loricrin, NLRR-1
This gene encodes loricrin, a major protein component of the cornified cell envelope found in terminally differentiated epidermal cells. Mutations in this gene are associated with Vohwinkel's syndrome and progressive symmetric erythrokeratoderma, both inherited skin diseases. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, cytokeratin, Involucrin, ACID, Filaggrin
Papers on LOR
The dynamics of serum anti-Mullerian-hormone levels during controlled ovarian hyperstimulation with GnRH-antagonist short protocol in polycystic ovary syndrome and low responders.
New
Eldar-Geva et al., Jerusalem, Israel. In Eur J Obstet Gynecol Reprod Biol, May 2014
OBJECTIVE: To determine whether the decrease in AMH levels during ovarian hyperstimulation for IVF occurs in patients with polycystic ovary syndrome (PCOS) and patients with low ovarian reserve (LOR), as in normal cycling women.
Staphylococcus aureus inhibits terminal differentiation of normal human keratinocytes by stimulating interleukin-6 secretion.
New
Lee et al., South Korea. In J Dermatol Sci, Apr 2014
NHKs treated with S. aureus extracts increased expression of interleukin (IL)-6 and significantly reduced expression of the terminal differentiation markers KRT 1, KRT 10, loricrin (LOR), and filaggrin (FLG); however, the expression of basal layer markers (KRT 5, KRT 14) remained unchanged.
Coordination modes of bidentate lornoxicam drug with some transition metal ions. Synthesis, characterization and in vitro antimicrobial and antibreastic cancer activity studies.
New
El-Dessouky et al., Al Jīzah, Egypt. In Spectrochim Acta A Mol Biomol Spectrosc, Apr 2014
The NSAID lornoxicam (LOR) drug was used for complex formation reactions with different metal salts like Cr(III), Mn(II), Fe(III) and Ni(II) chlorides and Fe(II), Co(II), Cu(II) and Zn(II) borates.
Mammalian SIRT2 inhibits keratin 19 expression and is a tumor suppressor in skin.
New
He et al., Chicago, United States. In Exp Dermatol, Mar 2014
In mice, SIRT2 deletion up-regulates K19 and K15 while it down-regulates the differentiation marker Loricrin in both normal skin and tumors.
Screening for key genes associated with atopic dermatitis with DNA microarrays.
New
He et al., Chengdu, China. In Mol Med Report, Mar 2014
including loricrin (LOR), keratin 17 (KRT17), small proline-rich repeat proteins (SPRRs) and involucrin (IVL).
GATA3 inhibits proliferation and induces expression of both early and late differentiation markers in keratinocytes of the human epidermis.
New
Lamartine et al., Lyon, France. In Arch Dermatol Res, Mar 2014
Moreover, GATA3 seems to be able to induce keratinocyte differentiation since its silencing leads to a decrease of both early and late differentiation markers such as Keratins 1 and 10, Involucrin and Loricrin.
C-reactive protein is an indicator of serum infliximab level in predicting loss of response in patients with Crohn's disease.
New
Matsui et al., Tokyo, Japan. In J Gastroenterol, Feb 2014
Here, we aimed to clarify the correlation between the timing of loss of response (LOR) to treatment and a decrease in serum infliximab level, and, in addition, to identify an indicator of infliximab level.
[Mutation analysis for GJB2 and LOR genes in two patients with Vohwinkel syndrome].
New
Zhang et al., Guangzhou, China. In Zhonghua Yi Xue Yi Chuan Xue Za Zhi, Apr 2013
OBJECTIVE: To detect potential mutations of gap junction protein beta 2 (GJB2) and loricrin (LOR) genes in two patients with Vohwinkel syndrome.
Cell-type specific inactivation of hippocampal CA1 disrupts location-dependent object recognition in the mouse.
New
Xu et al., Irvine, United States. In Learn Mem, Mar 2013
We chose to use a hippocampus-dependent behavioral task involving location-dependent object recognition (LOR).
Control of somatic tissue differentiation by the long non-coding RNA TINCR.
New
Impact
Khavari et al., Stanford, United States. In Nature, Feb 2013
TINCR is required for high messenger RNA abundance of key differentiation genes, many of which are mutated in human skin diseases, including FLG, LOR, ALOXE3, ALOX12B, ABCA12, CASP14 and ELOVL3.
A polyethylenimine-linoleic acid conjugate for antisense oligonucleotide delivery.
Lee et al., Changchun, China. In Biomed Res Int, 2012
A novel antisense oligonucleotide (ASO) carrier, polyethylenimine conjugated to linoleic acid (PEI-LA), was synthesized and evaluated for delivery of LOR-2501 to tumor cells.
Evidence for the absence of mutations at GJB3, GJB4 and LOR in progressive symmetrical erythrokeratodermia.
GeneRIF
Deng et al., Guangzhou, China. In Clin Exp Dermatol, 2011
There were no mutations found in the LOR gene and the true pathogenesis of progressive symmetrical erythrokeratodermia remains unknown.
mRNA-based skin identification for forensic applications.
GeneRIF
Kayser et al., Rotterdam, Netherlands. In Int J Legal Med, 2011
identified mRNA transcripts from three genes CDSN, LOR and KRT9, showing strong over-expression in skin samples relative to samples from forensic body fluids, making them suitable markers for skin identification
Activation of vascular endothelial growth factor receptor 2 in a cellular model of loricrin keratoderma.
GeneRIF
Kubota et al., Japan. In J Biol Chem, 2010
VEGF release and the subsequent activation of VEGF receptor 2 link loricrin gene mutations to rapid cell proliferation in a cellular model of loricrin keratoderma.
Protein kinase C delta and eta differently regulate the expression of loricrin and Jun family proteins in human keratinocytes.
GeneRIF
Ohba et al., Tokyo, Japan. In Biochem Biophys Res Commun, 2010
These findings suggest that inverse effects of PKCdelta and PKCeta on loricrin expression attributes to the expression of c-Jun and JunD.
Locus 1q21 Gene expression changes in atopic dermatitis skin lesions: deregulation of small proline-rich region 1A.
GeneRIF
Jarzab et al., Zabrze, Poland. In Int Arch Allergy Immunol, 2009
the deregulated increase in SPRR1A expression in chronic atopic skin lesions reflects an insufficient rise in SPRR transcripts, unable to compensate for the lack of LOR and thus contributing to the persistence of chronic atopic dermatitis skin lesions.
Towards characterization of palmoplantar keratoderma caused by gain-of-function mutation in loricrin: analysis of a family and review of the literature.
Review
Hennies et al., Köln, Germany. In Br J Dermatol, 2006
We identified the previously reported mutation 730insG in LOR, which elongates loricrin by 22 amino acids because of delayed termination.
Subcellular localization of the product of the long open reading frame of human T-cell leukemia virus type I.
Impact
Haseltine et al., In Science, 1985
In addition to containing the gag, pol, and env genes of the chronic leukemia viruses, the genome of HTLV-I contains a long open reading frame (LOR) located between the 3' end of the envelope gene and the 3' long terminal repeat sequence (LTR).
Antigens encoded by the 3'-terminal region of human T-cell leukemia virus: evidence for a functional gene.
Impact
Essex et al., In Science, 1984
Radiolabel sequence analysis of cyanogen bromide fragments of p42 led to the conclusion that this antigen is encoded in part by LOR, a conserved portion of the "X" region that is flanked by the envelope gene and the 3' long terminal repeat of HTLV-I.
Bovine leukemia virus, a distinguished member of the human T-lymphotropic virus family.
Review
Marbaix et al., In Princess Takamatsu Symp, 1983
The most striking feature of these retroviruses is the existence of a long open reading frame (LOR) located at the 3' side of the provirus between the right end of the 3' side of env gene and the left end of the long terminal repeat (LTR).
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